tectochrysin (CID 5281954) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(670)
 
 
Inconclusive(19)
 
 
Unspecified(41)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
PAS(10)
 
 
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(414)
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(66)
 
 
 
 
BioActivity Types:
Potency(176)
 
 
 
 
 
IC50(37)
 
 
 
EC50(13)
 
 
 
AC50(1)
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 711    Data Row: 747   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11113093]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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2
[SID11113093]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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3
[SID103418563]
Kd 6.3Effect of Chrysin Alkylation on the Binding to PgP Cytosolic Domain. [AID27150, Type: Literature]
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4
[SID26754333]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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5
[SID26754333]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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6
[SID26754333]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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7
[SID26725301]
AbsAC40_uM 14.179MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_Dose_CherryPick_Activity [AID540258, Type: confirmatory]
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8
[SID103418563]
IC50 23Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation after 20 hrs by Griess reagent method [AID358994, Type: Literature]
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9
[SID26725301]
AC50 46.163MITF Act Counter Assay: HeLa CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-08_Activator_Dose_CherryPick_Activity [AID540259, Type: confirmatory]
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10
[SID103418563]
IC50 49Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamidase release after 10 mins by microplate reader assay [AID359218, Type: Literature]
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11
[SID26725301]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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12
[SID24824136]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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13
[SID24824136]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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14
[SID11113093]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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15
[SID11113093]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID103418563]
 Effect on AhR-mediated CYP1A1 activation in mouse Hepa1c1c12 cells at 20 uM after 18 hrs by Western blot analysis [AID431868, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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17
[SID103418563]
 Effect on AhR-mediated NAPDH quinine reductase activation in mouse Hepa1c1c12 cells at 20 uM after 18 hrs by Western blot analysis [AID431869, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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18
[SID103418563]
 Induction of nuclear translocation of AhR from cytosol in mouse Hepa1 cells at 20 uM after 60 mins using DAPI staining by microscopic analysis [AID431870, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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19
[SID26725301]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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20
[SID26725301]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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21
[SID11113093]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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22
[SID11113093]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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23
[SID11113093]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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24
[SID11113093]
Potency 31.6228qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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25
[SID11113093]
Potency 31.6228qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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26
[SID11113093]
Potency 31.6228qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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27
[SID103418563]
EC50 226Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID334275, Type: Literature]
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28
[SID103418563]
EC50 273Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay [AID334279, Type: Literature]
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29
[SID103418563]
EC50 358Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID334276, Type: Literature]
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30
[SID103418563]
EC50 370Antiproliferative activity against human A549 cells after 72 hrs by MTT assay [AID334277, Type: Literature]
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31
[SID103418563]
EC50 370Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay [AID334278, Type: Literature]
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32
[SID103418563]
 Binding affinity to GABAA receptor [AID349305, Type: Literature]
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33
[SID103418563]
 Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation at 3 uM after 20 hrs by Griess reagent method relative to control [AID358990, Type: Literature]
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34
[SID103418563]
 Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation at 10 uM after 20 hrs by Griess reagent method relative to control [AID358991, Type: Literature]
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35
[SID103418563]
 Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation at 30 uM after 20 hrs by Griess reagent method relative to control [AID358992, Type: Literature]
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36
[SID103418563]
 Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation at 100 uM after 20 hrs by Griess reagent method relative to control [AID358993, Type: Literature]
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37
[SID103418563]
 Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression at 10 uM after 18 hrs measured as microunits of tissue factor/10'5 cells [AID400607, Type: Literature]
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38
[SID103418563]
 Cytotoxicity against human KB cells [AID404008, Type: Literature]
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39
[SID103418563]
 Cytotoxicity against ddY mouse macrophages after 20 hrs by MTT assay [AID359214, Type: Literature]
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40
[SID103418563]
 Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamidase release at 10 uM after 10 mins by microplate reader assay relative to control [AID359215, Type: Literature]
View
41
[SID103418563]
 Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamidase release at 30 uM after 10 mins by microplate reader assay relative to control [AID359216, Type: Literature]
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42
[SID103418563]
 Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamidase release at 100 uM after 10 mins by microplate reader assay relative to control [AID359217, Type: Literature]
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43
[SID103418563]
 Cytotoxicity against human COLO205 cells [AID410929, Type: Literature]
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44
[SID103418563]
 Cytotoxicity against human A431 cells [AID410930, Type: Literature]
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45
[SID103418563]
 Cytotoxicity against human MCF7 cells [AID410931, Type: Literature]
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46
[SID103418563]
 Cytotoxicity against human A549 cells [AID410932, Type: Literature]
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47
[SID103418563]
 Cytotoxicity against CHO cells [AID410933, Type: Literature]
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48
[SID103418563]
 Inhibition of rat alpha-glucosidase assessed as p-nitrophenol release at 50 ug/ml [AID436559, Type: Literature]
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49
[SID103418563]
 Direct binding to PgP recombinant cytosolic domain was measured by percent maximal quenching of the intrinsic fluorescence. [AID27159, Type: Literature]
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50
[SID103418563]
 Hydrophobicity index was determined in C18 reverse phase silica gel 20 * 20 cm plates in methanol:water (8:2). [AID28259, Type: Literature]
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