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Ellagic Acid (CID 5281855) - Compound BioActivity Data
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BioActivity Outcomes:
Active(273)
 
 
Inactive(806)
 
 
Inconclusive(129)
 
 
Unspecified(141)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(15)
 
 
 
NR LBD PPAR(15)
 
 
 
PLDc mTdp1 2(12)
 
 
 
 
BioAssay Types:
Confirmatory(546)
 
 
 
 
 
Screening(395)
 
 
 
 
 
Literature(301)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(409)
 
 
 
 
 
IC50(137)
 
 
 
 
 
Ki(20)
 
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1079    Data Row: 1349   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26748644]
Potency 0.004Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID489007, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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2
[SID103163815]
GI50 0.01Growth inhibitory activity against human cancer cell line in the NCI inverted question marks anticancer drug screening program [AID247402, Type: Literature]
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3
[SID26748644]
Potency 0.0112qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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4
[SID26748644]
Potency 0.0141Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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5
[SID103163815]
Ki 0.02Inhibition of rat liver CK2 by Lineweaver-Burke double reciprocal plot analysis [AID352791, Type: Literature]
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6
[SID103163815]
IC50 0.04Inhibition of rat liver CK2 catalytic activity [AID352792, Type: Literature]
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7
[SID103163815]
IC50 0.04Inhibition of rat liver CK2 [AID262917, Type: Literature]
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8
[SID103163815]
IC50 0.04Inhibition of CK2 in rat liver [AID317243, Type: Literature]
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9
[SID103163815]
IC50 0.04Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) [AID352795, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
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10
[SID87544482]
IC50 0.04187Late stage results for the probe development effort to identify inhibitors of tRNA 2'-phosphotransferase (TPT1): Fluorescence polarization-based biochemical dose response assay for TPT1 inhibitors [AID2838, Type: confirmatory]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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11
[SID8139882]
Potency 0.0447qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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12
[SID26748644]
Potency 0.0708qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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13
[SID103163815]
Ki 0.081Reaction rate parameter value for phosphate with transfer with respect to ATP [AID17435, Type: Literature]
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14
[SID26748644]
Potency 0.0891Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Assay [AID2564, Type: confirmatory]
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15
[SID26753737]
Potency 0.1qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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16
[SID103163815]
IC50 0.1Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins [AID663960, Type: other]G-protein coupled receptor 35 [gi:68068087]
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17
[SID26748644]
Potency 0.1qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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18
[SID103163815]
IC50 0.105Antiplasmodial activity against Plasmodium falciparum Dd2 [AID544214, Type: Literature]
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19
[SID103163815]
EC50 0.11Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay [AID663955, Type: other]G-protein coupled receptor 35 [gi:68068087]
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20
[SID26748644]
Potency 0.1259qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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21
[SID104171339]
Potency 0.1259qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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22
[SID26748644]
Potency 0.1259qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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23
[SID8139882]
IC50 0.142SMAD Transcription Factor Inhibitors Dose Response Confirmation [AID715, Type: confirmatory]mothers against decapentaplegic homolog 3 isoform 1 [Homo sapiens] [gi:5174513]
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24
[SID26748644]
Potency 0.1585qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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25
[SID26748644]
Potency 0.1585qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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26
[SID8139882]
Potency 0.1585qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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27
[SID103163815]
IC50 0.18Antiplasmodial activity against Plasmodium falciparum FcM29 [AID544217, Type: Literature]
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28
[SID103163815]
IC50 0.2Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry [AID639825, Type: Literature]Aldose reductase [gi:113596]
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29
[SID103163815]
IC50 0.21Inhibition of H(+)/K(+) ATPase from pig gastric mucosa [AID334756, Type: Literature]
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30
[SID103163815]
IC50 0.25Inhibition of human recombinant IGF1R expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting [AID650685, Type: Literature]Insulin-like growth factor 1 receptor [gi:124240]
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31
[SID11113162]
Potency 0.2512qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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32
[SID11113162]
Potency 0.2512qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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33
[SID124882875]
Potency 0.2512qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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34
[SID103163815]
IC50 0.26Inhibition of human recombinant TIE2 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting [AID650818, Type: Literature]Angiopoietin-1 receptor [gi:218511853]
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35
[SID103163815]
IC50 0.3Tested for in vitro inhibitory activity against tyrosine protein kinase pp60 c-src [AID219531, Type: Literature]
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36
[SID103163815]
IC50 0.3Antiplasmodial activity against Plasmodium falciparum FcB1 [AID544215, Type: Literature]
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37
[SID103163815]
IC50 0.33Antiplasmodial activity against Plasmodium falciparum W2 [AID544216, Type: Literature]
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38
[SID103163815]
IC50 0.33Antiplasmodial activity against Plasmodium falciparum F32 [AID544213, Type: Literature]
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39
[SID103163815]
IC50 0.34Inhibition of human recombinant INS-R expressed in Sf9 cells using poly(A,E,K,Y)6:2:5:1 as substrate after 80 mins by scintillation counting [AID650813, Type: Literature]Insulin receptor [gi:308153655]
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40
[SID103163815]
IC50 0.351Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 [AID580679, Type: Literature]
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41
[SID103163815]
IC50 0.51Inhibition of human recombinant ARK5 expressed in Sf9 cells assessed as autophosphorylation after 80 mins by scintillation counting [AID650675, Type: Literature]NUAK family SNF1-like kinase 1 [gi:14424095]
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42
[SID8139882]
IC50 0.54068Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID2160, Type: confirmatory]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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43
[SID8139882]
Potency 0.5623qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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44
[SID8139882]
Absolute IC50 0.57Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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45
[SID103163815]
IC50 0.58Inhibition of human recombinant MET expressed in Sf9 cells using poly(A,E,K,Y)6:2:5:1 as substrate after 80 mins by scintillation counting [AID650814, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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46
[SID103163815]
IC50 0.6In vitro inhibitory activity against protein kinase A [AID164783, Type: Literature]
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47
[SID103163815]
IC50 0.69Inhibition of human recombinant EGF-R expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting [AID650681, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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48
[SID8139882]
Potency 0.7079qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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49
[SID8139882]
IC50 0.76High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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50
[SID103163815]
IC50 0.79Inhibition of human recombinant VEGF-R2 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting [AID650811, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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