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psi-baptigenin (CID 5281805) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(9)
 
 
Unspecified(14)
 
 
Top Targets:
NR LBD PPAR(11)
 
 
 
BioAssay Types:
Literature(21)
 
 
 
 
Confirmatory(1)
 
 
BioActivity Types:
EC50(5)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 28    Data Row: 28   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103579151]
EC50 8.9Agonist activity at human PPARalpha assessed as luciferase activity by transactivation assay [AID439370, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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2
[SID103579151]
EC50 8.9Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736344, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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3
[SID103579151]
EC50 22.34Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736342, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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4
[SID103579151]
EC50 26.94Agonist activity at human PPARgamma expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736343, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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5
[SID103579151]
EC50 26.94Agonist activity at human PPARgamma assessed as luciferase activity by transactivation assay [AID439369, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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6
[SID103579151]
IC50 100Antiproliferative activity against human MCF7 cells after 72 hrs by MTS/PMS assay [AID456226, Type: Literature]
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7
[SID103579151]
IC50 100Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS/PMS assay [AID456227, Type: Literature]
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8
[SID103579151]
Cytotoxicity against human HEK293 cells assessed as cell viability at 10 uM measured after 48 hrs by MTS assay relative to vehicle control [AID736340, Type: Literature]
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9
[SID103579151]
Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as beta-galactosidase activity at 50 uM measured after 48 hrs relative to vehicle control [AID736341, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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10
[SID103579151]
Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as beta-galactosidase activity at 25 uM measured after 48 hrs relative to vehicle control [AID736345, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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11
[SID103579151]
Cytotoxicity against HEK293 cells assessed as viable cells at 10 uM after 48 hrs by aqueous one solution cell proliferation assay relative to control [AID439373, Type: Literature]
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12
[SID103579151]
Cytotoxicity against HEK293 cells assessed as viable cells at 100 uM after 48 hrs by aqueous one solution cell proliferation assay relative to control [AID439374, Type: Literature]
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13
[SID103579151]
Cytotoxicity against HEK293 cells assessed as viable cells at 50 uM after 48 hrs by aqueous one solution cell proliferation assay relative to control [AID439376, Type: Literature]
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14
[SID103579151]
Antifungal activity against Giardia intestinalis ATCC 30888 after 48 hrs by XTT assay [AID377875, Type: Literature]
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15
[SID103579151]
Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression at 10 uM after 18 hrs measured as microunits of tissue factor/10'5 cells [AID400607, Type: Literature]
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16
[SID103579151]
Agonist activity at human PPARgamma expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 5 uM after 48 hrs by reporter gene assay relative to control [AID439367, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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17
[SID103579151]
Agonist activity at human PPARgamma expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 25 uM after 48 hrs by reporter gene assay relative to control [AID439368, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
18
[SID103579151]
Agonist activity at human PPARalpha expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 25 uM after 48 hrs by reporter gene assay relative to control [AID439371, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
19
[SID103579151]
Agonist activity at human PPARalpha expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 40 uM after 48 hrs by reporter gene assay relative to control [AID439372, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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20
[SID103579151]
In vivo antitumor activity against rat Walker 256 cells [AID404068, Type: Literature]
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