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chicoric acid (CID 5281764) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(226)
 
 
Inconclusive(19)
 
 
Unspecified(14)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
NR LBD AR(9)
 
 
NR LBD TR(7)
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(213)
 
 
 
 
Literature(32)
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(194)
 
 
 
 
IC50(10)
 
 
EC50(5)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 266    Data Row: 278   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204044]
IC50 0.2Inhibitory activity against HIV-1 integrase; Range 0.1-0.2 uM [AID93682, Type: Literature]
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2
[SID103204044]
IC50 0.2Inhibition of HIV1 integrase using U5A/U5B double-stranded DNA as substrate by ELISA [AID392001, Type: Literature]
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3
[SID103204044]
IC50 0.22Inhibition of HIV NL4-3 recombinant histidine-tagged integrase 3'-end processing activity expressed in Escherichia coli BL21 (DE3) [AID536855, Type: Literature]
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4
[SID103204044]
IC50 0.27Inhibition of HIV NL4-3 recombinant histidine-tagged integrase strand transfer activity expressed in Escherichia coli BL21 (DE3) [AID536857, Type: Literature]
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5
[SID17389106]
Potency 0.5012qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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6
[SID17389106]
Potency 0.5012qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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7
[SID103204044]
IC50 0.8Inhibition of HIV-1 integrase by radiolabeled oligonucleotide-based assay integration [AID93385, Type: Literature]Integrase [gi:82312013]
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8
[SID103204044]
EC50 0.81Antiviral activity against HIV LAI infected in human MT2 cells assessed as protection against virus-induced cytopathic effect [AID536856, Type: Literature]
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9
[SID103204044]
IC50 1.1Compound was evaluated for the inhibitory concentration against HIV-1 integrase by radiolabeled oligonucleotide-based assay 3''-processing [AID93384, Type: Literature]Integrase [gi:82312013]
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10
[SID103204044]
Kd 3Kd value against HIV-1 integrase [AID91573, Type: Literature]
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11
[SID103204044]
EC50 5.3Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa) [AID105137, Type: Literature]
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12
[SID103204044]
EC50 12.7Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID392002, Type: Literature]
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13
[SID103204044]
EC50 12.7Cytotoxicity gainst human MT4 cells after 3 days by MTT assay [AID492211, Type: Literature]
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14
[SID103204044]
IC50 13.7Inhibitory activity against HIV-1 integrase [AID93364, Type: Literature]Integrase [gi:82312013]
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15
[SID103204044]
IC50 20.1Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen [AID45896, Type: Literature]
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16
[SID103204044]
EC50 21.2Concentration of compound required to protect 50% of cells against retroviral cytopathic effects in HIV-2 (ROD) [AID105141, Type: Literature]
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17
[SID103204044]
IC50 24.9Inhibitory activity against HIV-1 integrase [AID93382, Type: Literature]Integrase [gi:82312013]
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18
[SID103204044]
IC50 45Concentration of compound required to reduce MT-4 cell viability by 50% [AID105869, Type: Literature]
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19
[SID103204044]
Cytotoxicity against human MT2 cells assessed as concentration required to 5% inhibition of cell growth relative to control [AID536853, Type: Literature]
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20
[SID103204044]
CC50 115Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID492212, Type: Literature]
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