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chicoric acid (CID 5281764) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(222)
 
 
Inconclusive(22)
 
 
Unspecified(14)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
NR LBD AR(9)
 
 
NR LBD TR(7)
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(213)
 
 
 
 
Literature(31)
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(193)
 
 
 
 
IC50(10)
 
 
EC50(5)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 266    Data Row: 277   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204044]
IC50 0.2Inhibition of HIV1 integrase using U5A/U5B double-stranded DNA as substrate by ELISA [AID392001, Type: Literature]
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2
[SID103204044]
IC50 0.2Inhibitory activity against HIV-1 integrase; Range 0.1-0.2 uM [AID93682, Type: Literature]
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3
[SID103204044]
IC50 0.22Inhibition of HIV NL4-3 recombinant histidine-tagged integrase 3'-end processing activity expressed in Escherichia coli BL21 (DE3) [AID536855, Type: Literature]
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4
[SID103204044]
IC50 0.27Inhibition of HIV NL4-3 recombinant histidine-tagged integrase strand transfer activity expressed in Escherichia coli BL21 (DE3) [AID536857, Type: Literature]
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5
[SID17389106]
Potency 0.5012qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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6
[SID17389106]
Potency 0.5012qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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7
[SID103204044]
IC50 0.8Inhibition of HIV-1 integrase by radiolabeled oligonucleotide-based assay integration [AID93385, Type: Literature]Integrase [gi:82312013]
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8
[SID103204044]
EC50 0.81Antiviral activity against HIV LAI infected in human MT2 cells assessed as protection against virus-induced cytopathic effect [AID536856, Type: Literature]
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9
[SID103204044]
IC50 1.1Compound was evaluated for the inhibitory concentration against HIV-1 integrase by radiolabeled oligonucleotide-based assay 3''-processing [AID93384, Type: Literature]Integrase [gi:82312013]
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10
[SID103204044]
Kd 3Kd value against HIV-1 integrase [AID91573, Type: Literature]
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11
[SID103204044]
EC50 5.3Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa) [AID105137, Type: Literature]
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12
[SID103204044]
EC50 12.7Cytotoxicity gainst human MT4 cells after 3 days by MTT assay [AID492211, Type: Literature]
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13
[SID103204044]
EC50 12.7Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID392002, Type: Literature]
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14
[SID103204044]
IC50 13.7Inhibitory activity against HIV-1 integrase [AID93364, Type: Literature]Integrase [gi:82312013]
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15
[SID103204044]
IC50 20.1Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen [AID45896, Type: Literature]
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16
[SID103204044]
EC50 21.2Concentration of compound required to protect 50% of cells against retroviral cytopathic effects in HIV-2 (ROD) [AID105141, Type: Literature]
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17
[SID103204044]
IC50 24.9Inhibitory activity against HIV-1 integrase [AID93382, Type: Literature]Integrase [gi:82312013]
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18
[SID103204044]
IC50 45Concentration of compound required to reduce MT-4 cell viability by 50% [AID105869, Type: Literature]
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19
[SID103204044]
Cytotoxicity against human MT2 cells assessed as concentration required to 5% inhibition of cell growth relative to control [AID536853, Type: Literature]
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20
[SID103204044]
CC50 115Cytotoxicity against human MT4 cells by MTT assay [AID392003, Type: Literature]
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21
[SID103204044]
CC50 115Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID492212, Type: Literature]
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22
[SID103204044]
LD50 700Cytotoxicity against human MT2 cells after 48 hrs [AID362187, Type: Literature]
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23
[SID103204044]
Inhibition of HIV1 recombinant integrase expressed in Escherichia coli [AID375992, Type: Literature]
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24
[SID103204044]
Selectivity for HIV1 integrase over HIV1 reverse transcriptase [AID399886, Type: Literature]
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25
[SID103204044]
Inhibition of LCK SH2 domain at 200 uM [AID419926, Type: Literature]
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26
[SID103204044]
Cytotoxicity against human MT2 cells assessed as concentration required to 50% inhibition of cell growth relative to control [AID536854, Type: Literature]
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27
[SID103204044]
Inhibition of SRC SH2 domain at 200 uM [AID419927, Type: Literature]
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28
[SID103204044]
Inhibition of STAT1 SH2 domain at 200 uM [AID419928, Type: Literature]
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29
[SID103204044]
Inhibition of STAT3 SH2 domain at 200 uM [AID420054, Type: Literature]
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30
[SID103204044]
Inhibition of STAT5b SH2 domain at 200 uM [AID420055, Type: Literature]
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31
[SID17389106]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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32
[SID103204044]
Therapeutic index, ratio of CC50 for human MT4 cells to EC50 for HIV1 3B [AID492213, Type: Literature]
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33
[SID103204044]
Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen; Not reached due to cytotoxicity [AID45383, Type: Literature]
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34
[SID17389106]
Potency 3.3491qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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35
[SID144208253]
Potency-Replicate_1 61.5845qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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36
[SID144208253]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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37
[SID144208253]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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38
[SID144208253]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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39
[SID144208253]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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40
[SID144208253]
ER Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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41
[SID144208253]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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42
[SID144208253]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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43
[SID144208253]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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44
[SID144208253]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743239, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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45
[SID144208253]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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46
[SID17389106]
Potency-Replicate_1 qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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47
[SID17389106]
Potency qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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48
[SID17389106]
Potency qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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49
[SID17389106]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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50
[SID144208253]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View