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daidzein (CID 5281708) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(94)
 
 
Inactive(1103)
 
 
Inconclusive(201)
 
 
Unspecified(125)
 
 
Top Targets:
NR LBD PPAR(32)
 
 
 
 
NR LBD ER(30)
 
 
 
 
 
NR LBD TR(26)
 
 
 
7TM GPCR Srx(24)
 
 
 
NR LBD AR(20)
 
 
 
 
BioAssay Types:
Confirmatory(840)
 
 
 
 
 
Screening(380)
 
 
 
 
Literature(168)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(765)
 
 
 
 
 
IC50(59)
 
 
 
 
 
Ki(3)
 
 
 
Kd(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1027    Data Row: 1523   Total Pages: 31   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144213952]
Potency-Replicate_1 0.0015qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144213952]
Ratio Potency (uM) 0.275425qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID103166710]
Ki 0.3Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta [AID70660, Type: Literature]
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4
[SID103166710]
IC50 0.303Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay [AID70514, Type: Literature]
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5
[SID103166710]
IC50 0.45Displacement of fluorescent labeled ES2 from recombinant ERalpha [AID499822, Type: Literature]
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6
[SID46500432]
Potency 0.631qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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7
[SID144213952]
Potency-Replicate_1 0.7696qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID17389519]
Potency 0.7943qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID50126369]
Potency 0.8913qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID103166710]
IC50 1.1Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta [AID70654, Type: Literature]
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11
[SID103166710]
IC50 1.2Estrogenic activity in human Ishikawa cells assessed as induction of alkaline phosphatase activity after 4 days by para-nitrophenol release assay [AID361464, Type: Literature]
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12
[SID103166710]
IC50 1.2Displacement of [3H]estradiol from human recombinant ERbeta [AID361463, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID144213952]
Ratio Potency (uM) 1.49033qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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14
[SID144208642]
Potency-Replicate_1 1.5199qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID103166710]
Ki 1.8Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha [AID70353, Type: Literature]
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16
[SID103166710]
IC50 2.16Binding affinity against human estrogen receptor alpha in competitive binding assay [AID70199, Type: Literature]
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17
[SID103166710]
IC50 2.8Binding affinity for human Estrogen receptor beta [AID240680, Type: Literature]Estrogen receptor beta [gi:6166154]
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18
[SID144208642]
Potency-Replicate_1 3.0593qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID144208642]
Ratio Potency (uM) 4.32215qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144213952]
Potency-Replicate_1 4.8972qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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21
[SID103166710]
Kd 5.9Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor beta [gi:13124234]
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22
[SID103166710]
Kd 5.9Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor [gi:1706709]
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23
[SID144213952]
Potency-Replicate_1 6.1131qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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24
[SID103166710]
IC50 6.3Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha [AID70335, Type: Literature]
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25
[SID11114077]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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26
[SID90341229]
Potency 8.4368qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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27
[SID144208642]
AhR Potency (uM) 8.54718qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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28
[SID103166710]
IC50 9Inhibition of Hamster Liver mitochondrial ALDH-2 [AID31427, Type: Literature]
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29
[SID103166710]
IC50 9Inhibition of hamster liver ALDH2 [AID341733, Type: Literature]
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30
[SID103166710]
IC50 9Inhibition of hamster liver aldehyde dehydrogenase ALDH-2 [AID34047, Type: Literature]
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31
[SID90341229]
Potency 9.2qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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32
[SID11114077]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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33
[SID90341229]
Potency 10qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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34
[SID11114077]
Potency 10qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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35
[SID11114077]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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36
[SID50104845]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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37
[SID103166710]
IC50 13.63Inhibition of ALR2 (aldose reductase) of bovine lens [AID34338, Type: Literature]Aldose reductase [gi:113594]
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38
[SID103166710]
IC50 14Inhibition of Hamster Liver mitochondrial Monoamine oxidase. [AID125222, Type: Literature]
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39
[SID103166710]
IC50 14Inhibition of hamster liver mitochondrial monoamine oxidase MAO [AID125224, Type: Literature]
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40
[SID26747166]
Potency 15.8489qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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41
[SID11114077]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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42
[SID103166710]
IC50 17Displacement of [3H]estradiol from human recombinant ERalpha [AID356892, Type: Literature]Estrogen receptor [gi:544257]
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43
[SID17389519]
Potency 18.8336qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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44
[SID144208642]
Potency-Replicate_1 19.1348qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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45
[SID144213952]
Ratio Potency (uM) 20.1841qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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46
[SID90341229]
Potency 20.5878Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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47
[SID17389519]
Potency 21.1317qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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48
[SID103166710]
IC50 23.7Antitrypanosomal activity against Trypanosoma brucei brucei MITat 1.2 variant 221 after 72 hrs [AID378966, Type: Literature]
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49
[SID144213952]
Potency-Replicate_1 24.3365qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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50
[SID11114077]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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