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Coumestrol (CID 5281707) - Compound BioActivity Data
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BioActivity Outcomes:
Active(55)
 
 
Inactive(907)
 
 
Inconclusive(101)
 
 
Unspecified(14)
 
 
Top Targets:
7tm 4(44)
 
 
NR LBD PPAR(19)
 
 
 
alkPPc(14)
 
 
NR LBD ER(13)
 
 
 
 
Bcl-2 like(12)
 
 
 
BioAssay Types:
Screening(582)
 
 
 
 
Confirmatory(403)
 
 
 
 
 
Literature(28)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(289)
 
 
 
 
 
IC50(53)
 
 
 
 
 
EC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 967    Data Row: 1077   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204653]
IC50 0.002Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay [AID70514, Type: Literature]
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2
[SID103204653]
IC50 0.011Binding affinity against human estrogen receptor alpha in competitive binding assay [AID70199, Type: Literature]
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3
[SID103204653]
IC50 0.0186Binding affinity for human Estrogen receptor beta [AID240680, Type: Literature]Estrogen receptor beta [gi:6166154]
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4
[SID103204653]
IC50 0.0757Binding affinity for human Estrogen receptor Alpha [AID240695, Type: Literature]Estrogen receptor [gi:544257]
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5
[SID26751555]
Potency 0.3548qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144207230]
Potency-Replicate_1 5.0119qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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7
[SID855899]
Potency 7.9433qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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8
[SID855899]
IC50_Mean 14.7Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay [AID624383, Type: confirmatory]SUMO-1 [Homo sapiens] [gi:1762973]
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9
[SID855899]
Potency 19.0115qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID144207230]
Potency-Replicate_1 20.7888qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID855899]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID855899]
Potency 25.1189Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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13
[SID144207230]
Potency-Replicate_1 29.3649qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID26751554]
Potency 31.6228qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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15
[SID855899]
IC50 32.34Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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16
[SID855899]
Potency 35.4813qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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17
[SID855899]
Potency 39.8107qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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18
[SID124883324]
Potency 44.6684qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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19
[SID144207230]
AhR Potency (uM) 46.5402qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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20
[SID855899]
IC50 54.08Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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