wogonin (CID 5281703) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(359)
 
 
Inconclusive(9)
 
 
Unspecified(21)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
7TM GPCR Srsx(8)
 
 
 
Peptidase C48(5)
 
 
 
alkPPc(4)
 
 
APOBEC C(3)
 
 
BioAssay Types:
Screening(218)
 
 
 
Confirmatory(136)
 
 
 
 
 
Literature(38)
 
 
 
 
BioActivity Types:
Potency(69)
 
 
 
 
 
IC50(17)
 
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 398    Data Row: 398   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103180235]
IC50 1.07Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay [AID418268, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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2
[SID103180235]
IC50 1.08Evaluated for inhibition of COX-2 catalyzed PGE-2 production from LPS induced RAW 264.7 cells [AID166386, Type: Literature]
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3
[SID103180235]
Ki 2.04174Binding affinity towards benzodiazepine site in GABAA receptor [AID72729, Type: Literature]
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4
[SID103180235]
IC50 7.8Inhibition of iNOS-induced NO production in LPS-stimulated mouse BV2 cells after 24 hrs [AID654952, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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5
[SID85272354]
Potency 16.3601A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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6
[SID103180235]
IC50 39Antiinflammatory activity in PMA-stimulated human SW1353 cells assessed as inhibition of NF-kappaB activation [AID426206, Type: Literature]
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7
[SID103180235]
IC50 46Inhibition of COX2 [AID403340, Type: Literature]
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8
[SID85272354]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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9
[SID85272354]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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10
[SID103180235]
IC50 100Free radical scavenging activity of DPPH was determined [AID226689, Type: Literature]
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11
[SID103180235]
IC50 105Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA [AID403947, Type: Literature]
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12
[SID103180235]
IC50 176.1Inhibition of cow milk xanthine oxidase [AID338975, Type: other]Xanthine dehydrogenase/oxidase [gi:109940048]
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13
[SID103180235]
IC50 350Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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14
[SID103180235]
IC50 350Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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15
[SID103180235]
IC50 350Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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16
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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17
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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18
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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19
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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20
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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21
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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22
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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23
[SID103180235]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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24
[SID103180235]
 Cytotoxicity against human HMC1 cells assessed induction of morphological changes at 50 uM [AID474220, Type: Literature]
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25
[SID103180235]
 Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 1 uM on day 8 relative to control [AID596670, Type: Literature]
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26
[SID103180235]
 Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 3 uM on day 8 relative to control [AID596671, Type: Literature]
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27
[SID103180235]
 Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 10 uM on day 8 relative to control [AID596672, Type: Literature]
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28
[SID103180235]
 Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 30 uM on day 8 relative to control [AID596673, Type: Literature]
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29
[SID103180235]
 Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 10 uM by MTT assay [AID418269, Type: Literature]
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30
[SID103180235]
 Inhibition of COX-2 catalyzed PGE-2 production from LPS induced RAW 264.7 cells at concentration of 10 uM [AID166388, Type: Literature]
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31
[SID103180235]
 Cytotoxicity against african green monkey Vero cells upto 50 uM by neutral red assay [AID426207, Type: Literature]
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32
[SID103180235]
 Cytotoxicity against pig LLC-PK11 cells upto 50 uM by neutral red assay [AID426208, Type: Literature]
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33
[SID103180235]
 Cytotoxicity against human SW1353 cells by neutral red assay [AID426210, Type: Literature]
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34
[SID103180235]
 Binding affinity to GABAA receptor [AID349305, Type: Literature]
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35
[SID103180235]
 Inhibition of iNOS-induced NO production in LPS-stimulated mouse BV2 cells at 10 uM after 24 hrs [AID654951, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
View
36
[SID103180235]
 Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells at 10 uM by enzyme immunoassay [AID418267, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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37
[SID103180235]
 Inhibition of cow milk xanthine oxidase at 50 ug/mL [AID338974, Type: other]Xanthine dehydrogenase/oxidase [gi:109940048]
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38
[SID85272354]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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39
[SID85272354]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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40
[SID85272354]
Potency 1HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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41
[SID85272354]
Potency 17.7828qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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42
[SID85272354]
Potency 35.4813qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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43
[SID85272354]
Potency qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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44
[SID85272354]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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45
[SID85272354]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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46
[SID85272354]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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47
[SID85272354]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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48
[SID85272354]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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49
[SID85272354]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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50
[SID85272354]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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