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scutellarein (CID 5281697) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(4)
 
 
Inconclusive(1)
 
 
Unspecified(19)
 
 
Top Targets:
Sialidase(2)
 
 
Ald Xan dh C2(2)
 
 
 
STKc CDK5(1)
 
 
ig(1)
 
 
p450(1)
 
 
BioAssay Types:
Literature(34)
 
 
 
 
 
BioActivity Types:
IC50(8)
 
 
 
EC50(5)
 
 
 
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 34    Data Row: 34   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103242557]
Ki 0.22Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
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2
[SID103242557]
IC50 0.86Inhibition of SARS coronavirus nsP13 ATP hydrolysis activity expressed in Escherichia coli Rosetta assessed as inhibition of inorganic phosphate release by AM/MG-based colometric analysis in the presence of M13 ssDNA [AID671765, Type: Literature]
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3
[SID103242557]
Ki 1.64Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
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4
[SID103242557]
IC50 9.64Inhibition of human salivary alpha-amylase [AID404692, Type: Literature]Alpha-amylase 1 [gi:1351933]
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5
[SID103242557]
Ki 12.0226Binding affinity towards benzodiazepine site in GABAA receptor [AID72729, Type: Literature]
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6
[SID103242557]
IC50 12.6Inhibition of cow milk xanthine oxidase [AID338975, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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7
[SID103242557]
EC50 13.37Antioxidant activity assessed as ABTS radical scavenging activity [AID528045, Type: Literature]
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8
[SID103242557]
EC50 20.02Antioxidant activity of the compound assessed as DPPH radical scavenging activity after 30 mins [AID528043, Type: Literature]
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9
[SID103242557]
IC50 24.04Antioxidant activity assessed as inhibition of DPPH radical by spectrophotometric analysis using MTT assay method [AID718924, Type: Literature]
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10
[SID103242557]
Solubility of the compound in water by UV-visible spectrophotometry [AID718923, Type: Literature]
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11
[SID103242557]
IC50 10Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay [AID730328, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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12
[SID103242557]
IC50 50Inhibition of Trypanosoma cruzi trans-sialidase containing catalytic domain (N58F, R200K) and lectin-like domain (S495 K, V496G, E520K, D593G, I597D, H599R) mutation expressed in Escherichia coli JM109 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assay [AID466937, Type: Literature]
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13
[SID103242557]
IC50 55Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assay [AID466938, Type: Literature]Sialidase-2 [gi:229462907]
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14
[SID103242557]
IC50 67.2Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge [AID356482, Type: Literature]
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15
[SID103242557]
EC50 500000Antioxidant activity assessed as ferrous ion chelating activity [AID528044, Type: Literature]
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16
[SID103242557]
Antioxidant activity assessed as DDPH radical scavenging activity [AID502292, Type: Literature]
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17
[SID103242557]
Activity at CYP1A1 in microsomes of human MDA-MB468 cells assessed as parent compound remaining after 20 mins by HPLC analysis [AID598381, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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18
[SID103242557]
Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID481717, Type: Literature]Neuraminidase [gi:143955315]
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19
[SID103242557]
Inhibition of cow milk xanthine oxidase at 50 ug/mL [AID338974, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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20
[SID103242557]
Cytotoxicity against rat RBL2H3 cells at 500 uM by optical microscope [AID356483, Type: Literature]
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21
[SID103242557]
Cytotoxicity in human MCF10A cells at 2 uM measured every 24 hrs for 3 days by hematocytometry [AID671766, Type: Literature]
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22
[SID103242557]
Selectivity for Trypanosoma cruzi trans-sialidase mutant over human Neu2 [AID466939, Type: Literature]
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23
[SID103242557]
Cytotoxicity against human HMC1 cells assessed induction of cell death at 50 uM [AID474221, Type: Literature]
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24
[SID103242557]
Antithrombin activity in New Zealand white rabbit plasma assessed as activated partial thromboplastin time at 25 uM by coagulometer [AID718927, Type: Literature]
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25
[SID103242557]
Antithrombin activity in New Zealand white rabbit plasma assessed as thrombin time at 25 uM by coagulometer [AID718929, Type: Literature]
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26
[SID103242557]
Antithrombin activity in New Zealand white rabbit plasma assessed as fibrinogen content at 25 uM by coagulometer [AID718925, Type: Literature]
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27
[SID103242557]
Antithrombin activity in New Zealand white rabbit plasma assessed as prothrombin time at 25 uM by coagulometer [AID718926, Type: Literature]
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28
[SID103242557]
Inhibition of SARS coronavirus nsP13 ATP hydrolysis activity expressed in Escherichia coli Rosetta assessed as inhibition of inorganic phosphate release at 10 uM by AM/MG-based colometric analysis in the presence of M13 ssDNA [AID671763, Type: Literature]
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29
[SID103242557]
Activation factor, ratio of IC50 for non-CYP1 expressing human MCF10A to IC50 for CYP1 expressing human MDA-MB-468 cells [AID598380, Type: Literature]
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30
[SID103242557]
Inhibition of SARS coronavirus nsP13 helicase activity expressed in Escherichia coli Rosetta assessed inhibition of DNA unwinding activity at 10 uM by FRET assay [AID671761, Type: Literature]
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31
[SID103242557]
Inhibition of HCV NS3 helicase overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of DNA unwinding activity at 10 uM by FRET assay [AID671762, Type: Literature]
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32
[SID103242557]
Inhibition of HCV NS3 helicase ATP hydrolysis activity overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of inorganic phosphate release by AM/MG-based colometric analysis in the presence of M13 ssDNA [AID671764, Type: Literature]
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33
[SID103242557]
EC50 Cytoprotective activity against doxorubicin-induced cytotoxicity in rat H9c2 cells assessed as cell viability after 24 hrs by MTT assay [AID528046, Type: Literature]
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34
[SID103242557]
EC50 Inhibition of rat fetal brain CDK5 assessed as phosphorylated histone H1 levels by immuno-precipitation [AID400266, Type: Literature]Cyclin-dependent kinase 5 [gi:416783]
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