pachypodol (CID 5281677) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(7)
 
 
Unspecified(8)
 
 
BioAssay Types:
Literature(16)
 
 
 
 
BioActivity Types:
IC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103417331]
IC50 17.2Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C [AID587298, Type: Literature]
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2
[SID103417331]
 Maximal non-toxic dose (MNTD) that shows antiviral activity. [AID162242, Type: Literature]
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3
[SID103417331]
 Minimum drug concentration at which 99% of the polio virus is inhibited [AID162238, Type: Literature]
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4
[SID103417331]
 Cytotoxic dose at which 50% growth of normal cells is inhibited [AID162237, Type: Literature]
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5
[SID103417331]
 The ratio of the poliovirus viral titer of the virus control (reduction factor) to the viral titer in the presence of the maximal non-toxic dose (RF MNTD) [AID162244, Type: Literature]
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6
[SID103417331]
 Minimal dose which produces titer reduction at 10 ug/mL (mD RF10e3) [AID162249, Type: Literature]
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7
[SID103417331]
 Therapeutic Index measured as the ratio of CyD50(polio) / ED99(polio) values [AID235260, Type: Literature]
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8
[SID103417331]
IC50 Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation [AID319546, Type: Literature]
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9
[SID103417331]
 Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release [AID319548, Type: Literature]
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10
[SID103417331]
 Antimicrobial activity against Bacillus subtilis ATCC 6633 at 100 ug/mL by agar dilution assay [AID378629, Type: Literature]
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11
[SID103417331]
 Antimicrobial activity against Candida albicans ATCC 10231 at 100 ug/mL by agar dilution assay [AID378630, Type: Literature]
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12
[SID103417331]
 Antimicrobial activity against Escherichia coli ATCC 25922 at 100 ug/mL by agar dilution assay [AID378631, Type: Literature]
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13
[SID103417331]
 Antimicrobial activity against Mycobacterium smegmatis ATCC 35797 at 100 ug/mL by agar dilution assay [AID378632, Type: Literature]
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14
[SID103417331]
 Antimicrobial activity against Pseudomonas aeruginosa ATCC 15442 at 100 ug/mL by agar dilution assay [AID378633, Type: Literature]
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15
[SID103417331]
 Antimicrobial activity against Staphylococcus aureus ATCC 29213 at 100 ug/mL by agar dilution assay [AID378634, Type: Literature]
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16
[SID103417331]
 In vivo antitumor activity against mouse L1210 cells [AID404069, Type: Literature]
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