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galangin (CID 5281616) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(53)
 
 
Inactive(468)
 
 
Inconclusive(25)
 
 
Unspecified(99)
 
 
Top Targets:
7TM GPCR Srsx(16)
 
 
 
7TM GPCR Srx(14)
 
 
p450(9)
 
 
 
 
ABCC CFTR1(9)
 
 
 
 
GT1 Gtf like(7)
 
 
BioAssay Types:
Screening(280)
 
 
 
 
Confirmatory(194)
 
 
 
 
 
Literature(140)
 
 
 
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(36)
 
 
 
 
 
Ki(12)
 
 
 
EC50(8)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 594    Data Row: 645   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103274384]
IC50 0.025Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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2
[SID103274384]
IC50 0.04Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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3
[SID103274384]
IC50 0.077Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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4
[SID103274384]
Ki 0.863Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. [AID32023, Type: Literature]
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5
[SID103274384]
Ki 0.863Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes. [AID32357, Type: Literature]
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6
[SID103274384]
Ki 0.966Binding affinity at Adenosine A2 receptor in rat striatal membranes by [3H]-CGS- 21680 displacement. [AID33570, Type: Literature]
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7
[SID103274384]
Ki 0.966Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. [AID33936, Type: Literature]
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8
[SID103274384]
I50 1.67Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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9
[SID103274384]
IC50 1.8Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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10
[SID103274384]
Ki 3.15Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. [AID34709, Type: Literature]
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11
[SID103274384]
Ki 3.15Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cells [AID34885, Type: Literature]Adenosine receptor A3 [gi:1351831]
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12
[SID11113137]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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13
[SID85272545]
IC50_CF-PAF_Mean 3.27Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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14
[SID11113137]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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15
[SID103274384]
Kd 5.88844Binding affinity to ABCB1 nucleotide binding domain 2 [AID615921, Type: Literature]
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16
[SID103274384]
Kd 5.9Binding affinity to nucleotide-binding domain (NBD2) of P-Glycoprotein [AID150741, Type: Literature]Multidrug resistance protein 1A [gi:239938877]
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17
[SID103274384]
IC50 6.74Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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18
[SID103274384]
Ki 6.9Inhibition of human plasma BChE by Ellman's method [AID441659, Type: Literature]Cholinesterase [gi:116353]
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19
[SID85272545]
IC50_Mean 8.56Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID493002, Type: confirmatory]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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20
[SID85272545]
Potency 12.99qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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21
[SID26754241]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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22
[SID103274384]
Ki 16.7Binding affinity for HA-tagged wild type human Adenosine A2A receptor (WT) using [3H]CGS-21680 as radioligand expressed in COS-7 cells [AID34239, Type: Literature]Adenosine receptor A2a [gi:543740]
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23
[SID103274384]
IC50 17Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells after 72 hrs [AID450471, Type: Literature]
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24
[SID103274384]
Ki 18.1Binding affinity for HA-tagged mutant human Adenosine A2A receptor (V84L), using [3H]CGS-21680 as radioligand expressed in COS-7 cells [AID34238, Type: Literature]Adenosine receptor A2a [gi:543740]
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25
[SID103274384]
EC50 19.2Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay [AID334279, Type: Literature]
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26
[SID11113137]
Potency 19.9526qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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27
[SID103274384]
EC50 26.8Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID334275, Type: Literature]
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28
[SID103274384]
EC50 28Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay [AID332929, Type: Literature]
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29
[SID124882830]
Potency 29.8554qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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30
[SID103274384]
Ki 33Binding affinity for HA-tagged mutant human Adenosine A2A receptor (H250N) using [3H]-CGS-21,680 as radioligand expressed in COS-7 cells [AID34237, Type: Literature]Adenosine receptor A2a [gi:543740]
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31
[SID85272545]
IC50_Mean 35.5Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. [AID504672, Type: confirmatory]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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32
[SID103274384]
EC50 35.7Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID334276, Type: Literature]
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33
[SID103274384]
IC50 39.4Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 [AID265761, Type: Literature]
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34
[SID103274384]
EC50 40Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining [AID402473, Type: Literature]
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35
[SID103274384]
IC50 44Cytotoxicity against human H9 cells after 3 days [AID332930, Type: Literature]
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36
[SID103274384]
Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor. [AID33195, Type: Literature]
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37
[SID103274384]
Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment [AID402483, Type: Literature]
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38
[SID103274384]
Potentiation of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment [AID402484, Type: Literature]
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39
[SID103274384]
Inhibition of tyrosinase mRNA expression in theophyline-stimulated mouse B16-4A5 cells at 1 to 30 uM after 72 hrs [AID450484, Type: Literature]
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40
[SID103274384]
Inhibition of TRP1 mRNA expression in theophyline-stimulated mouse B16-4A5 cells at 1 to 30 uM after 72 hrs [AID450485, Type: Literature]
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41
[SID103274384]
Inhibition of TRP2 mRNA expression in theophyline-stimulated mouse B16-4A5 cells at 1 to 30 uM after 72 hrs [AID450486, Type: Literature]
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42
[SID103274384]
Inhibition of microphthalmia-associated transcriptional factor level in theophyline-stimulated mouse B16-4A5 cells at 1 to 30 uM after 48 hrs [AID450488, Type: Literature]
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43
[SID103274384]
Inhibition of reduced carboxymethylated kappa-casein fibril formation assessed as formation of shorter and stunted fibrils at 1 uM by transmission electron microscopy [AID456191, Type: Literature]
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44
[SID103274384]
Cytotoxicity against human PANC1 cells in nutrient-deprived condition assessed as preferential cell death after 24 hrs by trypan blue dye exclusion method [AID477928, Type: Literature]
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45
[SID103274384]
Antioxidant activity in BALB/c mouse BM cells assessed as inhibition of ROS production [AID293299, Type: Literature]
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46
[SID103274384]
Inhibition of GST-tagged Human papillomavirus 16 protein E6 interaction with His-tagged human caspase 8 expressed in Escherichia coli at 20 nM to 20 uM after 1 hr incubation followed by overnight incubation by Alpha screening technique [AID654747, Type: Literature]Protein E6 [gi:137757]
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47
[SID85272545]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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48
[SID85272545]
Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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49
[SID85272545]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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50
[SID85272545]
Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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