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galangin (CID 5281616) - Compound BioActivity Data
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BioActivity Outcomes:
Active(53)
 
 
Inactive(474)
 
 
Inconclusive(25)
 
 
Unspecified(99)
 
 
Top Targets:
7TM GPCR Srsx(16)
 
 
 
7TM GPCR Srx(14)
 
 
p450(9)
 
 
 
 
ABCC CFTR1(9)
 
 
 
 
GT1 Gtf like(7)
 
 
BioAssay Types:
Screening(280)
 
 
 
 
Confirmatory(194)
 
 
 
 
 
Literature(147)
 
 
 
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(36)
 
 
 
 
 
Ki(12)
 
 
 
EC50(8)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 594    Data Row: 651   Total Pages: 33   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103274384]
IC50 0.025Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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2
[SID103274384]
IC50 0.04Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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3
[SID103274384]
IC50 0.077Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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4
[SID103274384]
Ki 0.863Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. [AID32023, Type: Literature]
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5
[SID103274384]
Ki 0.863Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes. [AID32357, Type: Literature]
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6
[SID103274384]
Ki 0.966Binding affinity at Adenosine A2 receptor in rat striatal membranes by [3H]-CGS- 21680 displacement. [AID33570, Type: Literature]
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7
[SID103274384]
Ki 0.966Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. [AID33936, Type: Literature]
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8
[SID103274384]
I50 1.67Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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9
[SID103274384]
IC50 1.8Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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10
[SID103274384]
Ki 3.15Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. [AID34709, Type: Literature]
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11
[SID103274384]
Ki 3.15Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cells [AID34885, Type: Literature]Adenosine receptor A3 [gi:1351831]
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12
[SID11113137]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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13
[SID85272545]
IC50_CF-PAF_Mean 3.27Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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14
[SID11113137]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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15
[SID103274384]
Kd 5.88844Binding affinity to ABCB1 nucleotide binding domain 2 [AID615921, Type: Literature]
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16
[SID103274384]
Kd 5.9Binding affinity to nucleotide-binding domain (NBD2) of P-Glycoprotein [AID150741, Type: Literature]Multidrug resistance protein 1A [gi:239938877]
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17
[SID103274384]
IC50 6.74Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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18
[SID103274384]
Ki 6.9Inhibition of human plasma BChE by Ellman's method [AID441659, Type: Literature]Cholinesterase [gi:116353]
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19
[SID85272545]
IC50_Mean 8.56Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID493002, Type: confirmatory]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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20
[SID85272545]
Potency 12.99qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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