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fisetin (CID 5281614) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(95)
 
 
Inactive(228)
 
 
Inconclusive(39)
 
 
Unspecified(80)
 
 
Top Targets:
p450(10)
 
 
 
 
GT1 Gtf like(8)
 
 
HSD10-like SD..(8)
 
 
KAT11(8)
 
 
 
PLDc mTdp1 2(6)
 
 
 
 
BioAssay Types:
Confirmatory(256)
 
 
 
 
Literature(128)
 
 
 
 
Screening(10)
 
 
 
BioActivity Types:
Potency(153)
 
 
 
 
IC50(38)
 
 
 
 
EC50(6)
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 333    Data Row: 442   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103203131]
I50 0.015Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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2
[SID103203131]
I50 0.045Inhibition of beef heart mitochondrial succinoxidase assessed per mg of protein [AID338028, Type: Literature]
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3
[SID103203131]
IC50 0.2Inhibitory effect on the oxidative degradation of membrane lipids (lipid peroxidation assay) in microsomes of rat. [AID180466, Type: Literature]
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4
[SID103203131]
ID50 0.24Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: Literature]
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5
[SID103203131]
ID50 0.28Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: Literature]
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6
[SID103203131]
IC50 0.35Inhibition of CK2 [AID378676, Type: Literature]
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7
[SID124883072]
Potency 0.3981qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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8
[SID103203131]
IC50 0.42Inhibition of glycogen synthase kinase 3 [AID240981, Type: Literature]
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9
[SID103203131]
I50 0.48Inhibition of rat liver mitochondrial ATPase assessed per mg of protein [AID338025, Type: Literature]
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10
[SID124883071]
Potency 0.5623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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11
[SID103203131]
IC50 0.57Inhibition of Cyclin-dependent kinase 5-p25nck5a [AID241232, Type: Literature]
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12
[SID103203131]
IC50 0.79Inhibition of cyclin-dependent kinase 1/cyclinB [AID241206, Type: Literature]
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13
[SID103203131]
IC50 0.85Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin) [AID242481, Type: Literature]Cyclin-dependent kinase 6 [gi:266423]
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14
[SID26749675]
Potency 0.8913Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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15
[SID103203131]
IC50 0.95Inhibition of 12-hLO [AID309798, Type: Literature]
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16
[SID103203131]
IC50 1Inhibition of Plasmodium falciparum FabI [AID494830, Type: Literature]
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17
[SID103203131]
IC50 1Inhibition of FabI [AID265759, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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18
[SID11113263]
Potency 1.2589qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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19
[SID11113263]
Potency 1.2589qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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20
[SID103203131]
IC50 1.4Inhibition of 15-hLO1 [AID309799, Type: Literature]
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21
[SID103203131]
IC50 1.84Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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22
[SID26753766]
Potency 1.9953qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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23
[SID103203131]
EC50 2Neuroprotective activity in New Zealand white rabbit small clot embolism model assessed as reduction in stroke-induced behavioural deficits at 50 mg/kg, iv administered 5 mins post-embolization measured after 24 hrs [AID646594, Type: Literature]
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24
[SID103203131]
IC50 2Inhibition of FabZ [AID265758, Type: Literature]Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) [gi:74844869]
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25
[SID11113262]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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26
[SID11113262]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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27
[SID103203131]
EC50 2.8Neuroprotective effect against iodoacetic acid-induced ischemia in mouse HT22 cells treated simultaneously with iodoacetic acid for 2 hrs followed by incubation in fresh medium containing drug alone for 20 hrs measured after 4 hrs by MTT assay [AID397977, Type: Literature]
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28
[SID26749675]
Potency 2.8184Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Assay [AID2564, Type: confirmatory]
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29
[SID103203131]
EC50 3Neuroprotective activity in mouse HT22 cells assessed as reduction in IAA-induced ischemia after 24 hrs by MTT assay [AID646588, Type: Literature]
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30
[SID26749675]
Potency 3.1623qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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31
[SID103203131]
IC50 3.7Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
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32
[SID103203131]
IC50 4.1Inhibition of FabG [AID265760, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
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33
[SID103203131]
IC50 4.33Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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34
[SID103203131]
IC50 5Inhibition of CDK2 [AID298693, Type: Literature]
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35
[SID26749675]
Potency 5.0119qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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36
[SID26753766]
Potency 5.0119qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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37
[SID124883072]
Potency 5.9569qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID103203131]
IC50 6.5Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID265762, Type: Literature]
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39
[SID124883072]
Potency 6.6838qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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40
[SID103203131]
IC50 8.2Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 [AID265761, Type: Literature]
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41
[SID103203131]
IC50 8.2Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 [AID494832, Type: Literature]
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42
[SID103203131]
IC50 8.5IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration [AID93508, Type: Literature]
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43
[SID103203131]
IC50 10Inhibition of PI3K [AID378677, Type: Literature]
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44
[SID26753766]
Potency 11.2202qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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45
[SID26753766]
Potency 12.5893qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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46
[SID103203131]
IC50 13Inhibition of Beta-lactamase AmpC by quantitative high throughput screening [AID444613, Type: Literature]
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47
[SID26749675]
Potency 14.1254qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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48
[SID103203131]
IC50 15Inhibition of SYK [AID701071, Type: Literature]
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49
[SID26749675]
Potency 15.8489qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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50
[SID26753766]
Potency 15.8489qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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