Bookmark and Share
chrysin (CID 5281607) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(123)
 
 
Inactive(840)
 
 
Inconclusive(142)
 
 
Unspecified(210)
 
 
Top Targets:
p450(32)
 
 
 
 
 
NR LBD PPAR(19)
 
 
 
 
 
NR LBD TR(15)
 
 
 
 
7TM GPCR Srx(14)
 
 
PLDc mTdp1 2(12)
 
 
 
 
BioAssay Types:
Confirmatory(524)
 
 
 
 
 
Screening(365)
 
 
 
 
Literature(300)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(434)
 
 
 
 
 
IC50(87)
 
 
 
 
 
Ki(11)
 
 
EC50(10)
 
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1047    Data Row: 1315   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103180236]
IC50 0.001Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Aromatase [gi:117293]
View
2
[SID103180236]
Ki 0.016Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
View
3
[SID103180236]
IC50 0.024Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
View
4
[SID103180236]
Ki 0.042Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
View
5
[SID103180236]
IC50 0.054Inhibition of human CYP1A2 [AID517524, Type: Literature]Cytochrome P450 1A2 [gi:117144]
View
6
[SID103180236]
IC50 0.084Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
View
7
[SID103180236]
IC50 0.153Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
View
8
[SID103180236]
I50 0.25Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
View
9
[SID103180236]
IC50 0.57Inhibition of CYP1A2 (unknown origin)-mediated demethylation of resorufin methyl ether after 5 mins by spectrofluorimetric analysis [AID739409, Type: Literature]Cytochrome P450 1A2 [gi:117144]
View
10
[SID103180236]
IC50 0.67Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrate [AID347259, Type: Literature]Carbonyl reductase [NADPH] 1 [gi:118519]
View
11
[SID11112354]
Potency 0.7943qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
View
12
[SID103180236]
IC50 0.84Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
View
13
[SID103180236]
Ki 0.92In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (using [3H]- flumazenil as radioligand). [AID40670, Type: Literature]
View
14
[SID103180236]
IC50 1.29Inhibition of CYP1A1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis [AID739410, Type: Literature]Cytochrome P450 1A1 [gi:117139]
View
15
[SID103180236]
IC50 1.5Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [AID578759, Type: Literature]
View
16
[SID103180236]
IC50 1.5Inhibition of aromatase [AID654681, Type: Literature]
View
17
[SID103180236]
IC50 1.6Inhibition of Hamster Liver mitochondrial Monoamine oxidase. [AID125222, Type: Literature]
View
18
[SID103180236]
IC50 1.87Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
View
19
[SID103180236]
IC50 2.4Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
View
20
[SID26753723]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
21
[SID103180236]
Ki 2.6Apparent Ki against human aromatase [AID238451, Type: Literature]Aromatase [gi:117293]
View
22
[SID103180236]
IC50 2.6Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining [AID578760, Type: Literature]
View
23
[SID103180236]
Ki 2.65Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay [AID657372, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
View
24
[SID103180236]
Ki 2.71Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 12 hrs by stopped flow CO2 hydration assay [AID657373, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
View
25
[SID103180236]
Ki 3.01995Binding affinity towards benzodiazepine site in GABAA receptor [AID72729, Type: Literature]
View
26
[SID103180236]
IC50 3.1In vitro inhibitory concentration required against human colorectal adenocarcinoma HT-29 cell line [AID83625, Type: Literature]
View
27
[SID103180236]
IC50 3.1Inhibition of Cyclin-dependent kinase 5-p25nck5a [AID241232, Type: Literature]
View
28
[SID144212652]
Potency-Replicate_1 3.8571qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
29
[SID103180236]
IC50 3.9Hypochlorous acid scavenging activity assessed as inhibition of DHR oxidation [AID289322, Type: Literature]
View
30
[SID26748375]
Potency 3.9811qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
View
31
[SID103180236]
Ki 4.31Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 12 hrs by stopped flow CO2 hydration assay [AID657371, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
32
[SID103180236]
EC50 5Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay [AID332929, Type: Literature]
View
33
[SID144212652]
Ratio Potency (uM) 5.04574qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
View
34
[SID103180236]
IC50 5.225Inhibition of human CYP2C9 [AID517525, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
View
35
[SID103180236]
Ki 5.42Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 12 hrs by stopped flow CO2 hydration assay [AID657369, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
36
[SID103180236]
IC50 5.8In vitro inhibitory concentration required against human gastric adenocarcinoma SGC-7901 cell line [AID201445, Type: Literature]
View
37
[SID103180236]
IC50 6Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin) [AID242481, Type: Literature]Cyclin-dependent kinase 6 [gi:266423]
View
38
[SID11112354]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
View
39
[SID103180236]
IC50 7.1Inhibition of cyclin-dependent kinase 1/cyclinB [AID241206, Type: Literature]
View
40
[SID103180236]
IC50 7.2Inhibition of glycogen synthase kinase 3 [AID240981, Type: Literature]
View
41
[SID103180236]
IC50 7.78Inhibition of aldose reductase by spectrophotometric analysis [AID568209, Type: Literature]
View
42
[SID103180236]
IC50 7.79Inhibition of aldose reductase from calf lense by AR assay [AID480503, Type: Literature]Aldose reductase [gi:113594]
View
43
[SID26748373]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
44
[SID103180236]
IC50 8.5Inhibition of human recombinant aldose reductase [AID322413, Type: Literature]Aldose reductase [gi:113596]
View
45
[SID26748375]
Potency 8.9125qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
46
[SID103180236]
Kd 8.91251Binding affinity to ABCB1 nucleotide binding domain 2 [AID615921, Type: Literature]
View
47
[SID103180236]
Ki 8.96Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay [AID657374, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
View
48
[SID103180236]
Ki 9.07Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 12 hrs by stopped flow CO2 hydration assay [AID657375, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
View
49
[SID103180236]
IC50 10Inhibition of FabG [AID265760, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
View
50
[SID26753723]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View