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BioActivity Data for Compound chrysin (CID 5281607)

BioActivity Outcomes:
Active(143)
 
 
Inactive(863)
 
 
Inconclusive(144)
 
 
Unspecified(276)
 
 
Top Targets:
p450(33)
 
 
 
 
 
7tm 4(26)
 
 
NR LBD PPAR(19)
 
 
 
 
 
NR LBD TR(15)
 
 
 
 
PLDc mTdp1 2(12)
 
 
 
 
BioAssay Types:
Confirmatory(544)
 
 
 
 
 
Literature(385)
 
 
 
 
 
Screening(366)
 
 
 
 
Summary(27)
 
 
 
 
BioAssay Categories:
In vitro(20)
 
 
 
 
 
In vivo(8)
 
 
 
Biochemical(250)
 
 
 
 
 
Toxicity(76)
 
 
 
 
 
ADME(43)
 
 
 
Cell-based(265)
 
 
 
 
 
Organism-base..(13)
 
 
 
BioActivity Types:
Potency(448)
 
 
 
 
 
IC50(105)
 
 
 
 
 
Ki(14)
 
 
EC50(10)
 
 
 
 
Kd(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1148    Data Row: 1426   Total Pages: 72   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103180236]
IC50 0.001Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Aromatase [gi:117293]
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2
[SID103180236]
Ki 0.016Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
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3
[SID103180236]
IC50 0.024Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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4
[SID103180236]
Ki 0.042Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
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5
[SID103180236]
IC50 0.054Inhibition of human CYP1A2 [AID517524, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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6
[SID103180236]
IC50 0.084Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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7
[SID103180236]
IC50 0.153Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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8
[SID103180236]
I50 0.25Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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9
[SID103180236]
IC50 0.57Inhibition of CYP1A2 (unknown origin)-mediated demethylation of resorufin methyl ether after 5 mins by spectrofluorimetric analysis [AID739409, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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10
[SID11112354]
Potency 0.7943qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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11
[SID103180236]
IC50 0.8Inhibition of aromatase (unknown origin) [AID1077761, Type: confirmatory]Aromatase [gi:117293]
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12
[SID103180236]
IC50 0.84Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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13
[SID103180236]
Ki 0.92In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (using [3H]- flumazenil as radioligand). [AID40670, Type: Literature]
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14
[SID103180236]
IC50 1.29Inhibition of CYP1A1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis [AID739410, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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15
[SID103180236]
IC50 1.4Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed by addition of Flag-LEDGF/p75 for 1 hr by AlphaScreen assay [AID1152254, Type: Literature]Integrase [gi:82312013]
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16
[SID170484816]
Kd 1.4Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Wild Type Ttr Binding Chrysin (Ttrwt:chr) [gi:422919335]
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17
[SID170484816]
Kd 1.4Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Wild Type Ttr Binding Chrysin (Ttrwt:chr) [gi:422919335]
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18
[SID103180236]
IC50 1.5Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [AID578759, Type: Literature]
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19
[SID103180236]
IC50 1.5Inhibition of aromatase [AID654681, Type: Literature]
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20
[SID103180236]
IC50 1.6Inhibition of Hamster Liver mitochondrial Monoamine oxidase. [AID125222, Type: Literature]
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