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Zearalenone (CID 5281576) - Compound BioActivity Data
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BioActivity Outcomes:
Active(175)
 
 
Inactive(1206)
 
 
Inconclusive(425)
 
 
Unspecified(43)
 
 
Top Targets:
NR LBD PPAR(35)
 
 
 
 
7TM GPCR Srx(25)
 
 
NR LBD ER(23)
 
 
 
 
NR LBD TR(20)
 
 
 
 
NR LBD AR(20)
 
 
 
 
BioAssay Types:
Confirmatory(720)
 
 
 
 
 
Screening(648)
 
 
 
 
 
Summary(48)
 
 
 
 
Literature(46)
 
 
 
 
 
BioActivity Types:
Potency(584)
 
 
 
 
 
IC50(67)
 
 
 
 
 
EC50(15)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1098    Data Row: 1849   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17388663]
Potency 0.01qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144208351]
Potency-Replicate_1 0.0133qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144213818]
Potency-Replicate_1 0.0715qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID103592240]
EC50 0.11Agonist activity at ERbeta by fluorescence polarization assay [AID356007, Type: Literature]
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5
[SID144208351]
Ratio Potency (uM) 0.127982qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144213818]
Ratio Potency (uM) 0.148106qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
7
[SID17388663]
Potency 0.3162qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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8
[SID17389683]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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9
[SID144208351]
Potency-Replicate_1 2.3439qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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10
[SID3714463]
IC50 2.402Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]90-kda heat shock protein beta HSP90 beta [Homo sapiens] [gi:4261762]
View
11
[SID3714463]
IC50 2.402Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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12
[SID144208351]
Ratio Potency (uM) 4.16811qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID144213818]
Potency-Replicate_1 4.4731qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
14
[SID3714463]
EC50_uM 5.449Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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15
[SID144213818]
Ratio Potency (uM) 5.85159qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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16
[SID3714463]
IC50 6.922TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2) [AID1641, Type: confirmatory]PTK2B protein tyrosine kinase 2 beta [Homo sapiens] [gi:34784998]
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17
[SID144213818]
Potency-Replicate_1 7.9544qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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18
[SID144213818]
Potency-Replicate_1 8.925qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
19
[SID144208351]
Potency-Replicate_1 9.3312qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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20
[SID144208351]
Ratio Potency (uM) 10.4698qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
View
21
[SID17388663]
Potency-Replicate_1 11.2202qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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22
[SID17389683]
Potency 11.2202qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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23
[SID144208351]
Potency-Replicate_1 11.7473qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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24
[SID3714463]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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25
[SID144208351]
Ratio Potency (uM) 14.0908qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
View
26
[SID17388663]
Potency 14.1254qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
27
[SID3714463]
Potency 14.1254qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
28
[SID3714463]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
View
29
[SID144213818]
ER Potency (uM) 14.1451qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
30
[SID17389683]
Potency 14.9889qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
31
[SID144213818]
Ratio Potency (uM) 15.4091qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
View
32
[SID144213818]
Potency-Replicate_1 15.8711qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
33
[SID144208351]
Potency-Replicate_1 16.5935qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
34
[SID144208351]
Potency-Replicate_1 16.5935qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
35
[SID144208351]
Potency-Replicate_1 16.5935qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
36
[SID144213818]
Potency-Replicate_1 17.9657qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743215, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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37
[SID144208351]
Potency-Replicate_1 18.6182qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
View
38
[SID144213818]
Ratio Potency (uM) 19.3989qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
39
[SID144213818]
Potency-Replicate_1 19.9805qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
View
40
[SID144213818]
Potency-Replicate_1 19.9805qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
View
41
[SID3714463]
Potency 20.5962qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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42
[SID144208351]
Potency-Replicate_1 20.89qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
43
[SID144208351]
Potency-Replicate_1 20.89qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
View
44
[SID144213818]
Potency-Replicate_1 22.4185qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
45
[SID144213818]
Potency-Replicate_1 22.4185qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
46
[SID144213818]
Potency-Replicate_1 22.4185qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
47
[SID144213818]
Ratio Potency (uM) 22.4185qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
View
48
[SID144208351]
Potency-Replicate_1 23.439qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
View
49
[SID144208351]
Potency-Replicate_1 23.439qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
View
50
[SID17388663]
Potency 33.4915qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
View