yangonin (CID 5281575) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(224)
 
 
Inconclusive(25)
 
 
Unspecified(3)
 
 
Top Targets:
NR LBD TR(6)
 
 
NR LBD PPAR(5)
 
 
 
NR LBD ROR li..(5)
 
 
Peptidase C1A(4)
 
 
P53(3)
 
 
 
BioAssay Types:
Confirmatory(235)
 
 
 
 
Screening(5)
 
 
 
Literature(5)
 
 
 
 
BioActivity Types:
Potency(141)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 232    Data Row: 261   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17388664]
Potency 1.8834qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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2
[SID17388664]
Potency 1.8834qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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3
[SID17388664]
Potency 1.8834qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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4
[SID17388664]
Potency 1.8834qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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5
[SID17388664]
Potency 10qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID17388664]
Potency 10qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID17388664]
Potency 10qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID17388664]
Potency 50.1187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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9
[SID17388664]
Potency 66.8242qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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10
[SID17388664]
Potency 66.8242qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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11
[SID17388664]
Potency 66.8242qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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12
[SID26753133]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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13
[SID26753133]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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14
[SID103752976]
 Induction of HO-1 protein expression in rat PC12 cells at 10 uM after 24 hrs by western blot analysis [AID481211, Type: Literature]
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15
[SID17388664]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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16
[SID103752976]
 Activation of Nrf2 in rat PC12 cells at 10 uM after 24 hrs by antioxidant response element-driven luciferase reporter gene assay [AID481210, Type: Literature]Nuclear factor erythroid 2-related factor 2 [gi:146345467]
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17
[SID17388664]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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18
[SID103752976]
 Inhibition of PA endonuclease at 10 uM [AID666150, Type: Literature]
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19
[SID103752976]
 Inhibition of PA endonuclease at 1 uM [AID666151, Type: Literature]
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20
[SID17388664]
Potency 1.8834qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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21
[SID17388664]
Potency 1.8834qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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22
[SID17388664]
Potency 1.8834qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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23
[SID17388664]
Potency 1.8834qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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24
[SID17388664]
Potency 1.8834qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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25
[SID17388664]
Potency 25.1189qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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26
[SID17388664]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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27
[SID26753133]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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28
[SID26753133]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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29
[SID26753133]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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30
[SID26753133]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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31
[SID46487971]
 A Validation Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor Using a Diverse Compound Set [AID999, Type: screening]
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32
[SID46487971]
 A Validation Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression Using a Diverse Compound Set [AID1004, Type: screening]
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33
[SID17388664]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
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34
[SID17388664]
Potency qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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35
[SID17388664]
Potency qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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36
[SID17388664]
 Cell Viability - H-4-II-E [AID543, Type: confirmatory]
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37
[SID17388664]
 Cell Viability - Renal Proximal Tubule [AID545, Type: confirmatory]
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38
[SID17388664]
 Cell Viability - Mesenchymal [AID546, Type: confirmatory]
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39
[SID17388664]
 Cellular Toxicity (caspase-3) HepG2 [AID654, Type: confirmatory]
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40
[SID17388664]
 Cellular Toxicity (caspase-3) Jurkat [AID655, Type: confirmatory]
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41
[SID17388664]
 Cellular Toxicity (caspase-3) HUV-EC-C [AID656, Type: confirmatory]
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42
[SID17388664]
 Cellular Toxicity (caspase-3) SHSY5Y [AID657, Type: confirmatory]
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43
[SID17388664]
 Cellular Toxicity (caspase-3) BJ [AID658, Type: confirmatory]
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44
[SID17388664]
 Cellular Toxicity (caspase-3) MRC-5 [AID659, Type: confirmatory]
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45
[SID17388664]
 Cellular Toxicity (caspase-3) Mesangial [AID660, Type: confirmatory]
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46
[SID17388664]
 Cellular Toxicity (caspase-3) SK-N-SH [AID661, Type: confirmatory]
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47
[SID17388664]
 Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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48
[SID17388664]
 Cellular Toxicity (caspase-3) H-4-II-E [AID663, Type: confirmatory]
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49
[SID17388664]
 Cellular Toxicity (caspase-3) Hek293 [AID664, Type: confirmatory]
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50
[SID17388664]
 Cellular Toxicity (caspase-3) N2a [AID665, Type: confirmatory]
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