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yangonin (CID 5281575) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(18)
 
 
Inactive(296)
 
 
Inconclusive(46)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD TR(9)
 
 
NR LBD AR(9)
 
 
 
NR LBD VDR(7)
 
 
BioAssay Types:
Confirmatory(311)
 
 
 
 
Summary(24)
 
 
 
 
Screening(7)
 
 
 
Literature(7)
 
 
 
 
BioActivity Types:
Potency(233)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 328    Data Row: 365   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144209745]
Potency-Replicate_1 0.4429qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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2
[SID144209745]
Ratio Potency (uM) 0.557615qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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3
[SID144209745]
Potency-Replicate_1 0.8838qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID26753133]
Potency 1.7783qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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5
[SID17388664]
Potency 1.8834qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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6
[SID26753133]
Potency 8.9125qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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7
[SID17388664]
Potency 10qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID144209745]
ATAD5 Potency (uM) 19.7849qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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9
[SID17388664]
Potency-Replicate_1 35.4813qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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10
[SID17388664]
Potency 50.1187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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11
[SID17388664]
Potency 66.8242qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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12
[SID17388664]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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13
[SID26753133]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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14
[SID26753133]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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15
[SID26753133]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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16
[SID26753133]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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17
[SID103752976]
Activation of Nrf2 in rat PC12 cells at 10 uM after 24 hrs by antioxidant response element-driven luciferase reporter gene assay [AID481210, Type: Literature]Nuclear factor erythroid 2-related factor 2 [gi:146345467]
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18
[SID103752976]
Induction of HO-1 protein expression in rat PC12 cells at 10 uM after 24 hrs by western blot analysis [AID481211, Type: Literature]
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19
[SID103752976]
Inhibition of PA endonuclease at 10 uM [AID666150, Type: Literature]Polymerase acidic protein [gi:158931133]
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20
[SID103752976]
Inhibition of PA endonuclease at 1 uM [AID666151, Type: Literature]Polymerase acidic protein [gi:158931133]
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21
[SID17388664]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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22
[SID103752976]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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23
[SID103752976]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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24
[SID26753133]
Potency 1.122qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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25
[SID144209745]
Potency-Replicate_1 1.4007qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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26
[SID17388664]
Potency 1.8834qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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27
[SID144209745]
Potency-Replicate_1 14.0067qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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28
[SID17388664]
Potency 25.1189qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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29
[SID26753133]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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30
[SID26753133]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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31
[SID26753133]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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32
[SID26753133]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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33
[SID46487971]
A Validation Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor Using a Diverse Compound Set [AID999, Type: screening]
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34
[SID46487971]
A Validation Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression Using a Diverse Compound Set [AID1004, Type: screening]
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35
[SID17388664]
Potency qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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36
[SID17388664]
Potency qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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37
[SID17388664]
Cell Viability - H-4-II-E [AID543, Type: confirmatory]
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38
[SID17388664]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
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39
[SID17388664]
Potency-Replicate_1 qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID720652, Type: confirmatory]
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40
[SID17388664]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity - cell viability counter screen [AID720653, Type: confirmatory]
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41
[SID17388664]
Potency qHTS assay for cell viability of HEK293 cells [AID743288, Type: confirmatory]
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42
[SID17388664]
Potency qHTS assay for cell viability of the p53RE-bla HCT-116 cell line [AID743292, Type: confirmatory]
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43
[SID144209745]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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44
[SID144209745]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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45
[SID144209745]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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46
[SID144209745]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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47
[SID144209745]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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48
[SID144209745]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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49
[SID144209745]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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50
[SID144209745]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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