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Esculin (CID 5281417) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(78)
 
 
Inconclusive(40)
 
 
Unspecified(18)
 
 
Top Targets:
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD GR(4)
 
 
 
NR LBD TR(3)
 
 
PLDc mTdp1 2(2)
 
 
BioAssay Types:
Confirmatory(50)
 
 
 
 
Screening(22)
 
 
Summary(15)
 
 
 
 
Literature(12)
 
 
 
BioActivity Types:
Potency(63)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 144    Data Row: 144   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204004]
Potency-Replicate_1 7.1669qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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2
[SID144204004]
Potency-Replicate_1 8.9125qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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3
[SID144204004]
Potency-Replicate_1 8.9125qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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4
[SID144204004]
Potency-Replicate_1 9.0993qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144204004]
Ratio Potency (uM) 9.83631qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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6
[SID144204004]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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7
[SID144204004]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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8
[SID144204004]
Potency-Replicate_1 10.2096qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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9
[SID103618707]
Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL (experiment 1) [AID91564, Type: Literature]
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10
[SID103618707]
Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL (experiment 2) [AID91565, Type: Literature]
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11
[SID103618707]
Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by strand transfer method at 100 micro g/mL (experiment 1) [AID91568, Type: Literature]
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12
[SID103618707]
Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by strand transfer method at 100 micro g/mL (experiment 2) [AID91569, Type: Literature]
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13
[SID103618707]
Compound was tested for its inhibitory effect on MAO-A ( Monoamine Oxidase) at 100 uM [AID126220, Type: Literature]
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14
[SID103618707]
Compound was tested for its inhibitory effect on MAO-B ( Monoamine Oxidase) at 100 uM [AID127175, Type: Literature]
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15
[SID103618707]
Inhibition of COX2 at 100 uM by scintillation proximity assay [AID336478, Type: Literature]
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16
[SID103618707]
Inhibition of HIV1 RT [AID397122, Type: Literature]
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17
[SID8149864]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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18
[SID8149864]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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19
[SID8149864]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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20
[SID8149864]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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