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BioActivity Data for Compound Esculin (CID 5281417)

BioActivity Outcomes:
Active(7)
 
 
Inactive(78)
 
 
Inconclusive(41)
 
 
Unspecified(18)
 
 
Top Targets:
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
 
7tm 4(4)
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
BioAssay Types:
Confirmatory(50)
 
 
 
 
Screening(22)
 
 
Summary(15)
 
 
 
 
Literature(12)
 
 
 
BioAssay Categories:
In vitro(5)
 
 
 
In vivo(2)
 
 
Biochemical(10)
 
 
 
Toxicity(17)
 
 
 
Cell-based(18)
 
 
 
 
Organism-base..(2)
 
 
BioActivity Types:
Potency(63)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 144    Data Row: 144   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204004]
Potency-Replicate_1 7.1669qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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2
[SID144204004]
Potency-Replicate_1 8.9125qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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3
[SID144204004]
Potency-Replicate_1 8.9125qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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4
[SID144204004]
Potency-Replicate_1 9.0993qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144204004]
Ratio Potency (uM) 9.83631qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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6
[SID144204004]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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7
[SID144204004]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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8
[SID8149864]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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9
[SID8149864]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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10
[SID8149864]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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11
[SID8149864]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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12
[SID8149864]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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13
[SID8149864]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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14
[SID8149864]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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15
[SID8149864]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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16
[SID103618707]
Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL (experiment 1) [AID91564, Type: Literature]
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17
[SID8149864]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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18
[SID103618707]
Inhibition of COX2 at 100 uM by scintillation proximity assay [AID336478, Type: Literature]
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19
[SID8149864]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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20
[SID103618707]
Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL (experiment 2) [AID91565, Type: Literature]
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