fucoxanthin (CID 5281239) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(319)
 
 
Inconclusive(22)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
TRP 2(5)
 
 
Tryp SPc(5)
 
 
 
G-alpha(5)
 
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(186)
 
 
 
 
Confirmatory(154)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(116)
 
 
 
 
 
IC50(27)
 
 
EC50(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 348    Data Row: 348   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26732645]
Potency 3.1623qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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2
[SID26732645]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID26732645]
Potency 25.1189qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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4
[SID26732645]
Potency 25.1189qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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5
[SID26732645]
Potency 25.929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID26732645]
Potency 25.929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID26732645]
Potency 25.929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID26732645]
Potency 35.4813qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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9
[SID26732645]
Potency 35.4813qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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10
[SID26732645]
 QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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11
[SID26732645]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID26732645]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID26732645]
Potency 25.1189qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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14
[SID26732645]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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15
[SID26732645]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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16
[SID26732645]
Potency qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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17
[SID26732645]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID26732645]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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19
[SID26732645]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2 [Saccharomyces cerevisiae] [gi:171229]
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20
[SID26732645]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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21
[SID26732645]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN. [AID2025, Type: screening]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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22
[SID26732645]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
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23
[SID26732645]
 Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compound [AID1979, Type: screening]heat shock protein 90 [Candida albicans] [gi:994798]
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24
[SID26732645]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ MEP2_MLPCN. [AID2016, Type: screening]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
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25
[SID26732645]
Potency qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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26
[SID26732645]
 Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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27
[SID26732645]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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28
[SID26732645]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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29
[SID26732645]
 C. albicans biofilm killing---Mixture HTS [AID1242, Type: screening]glycosyl-phosphatidylinositol protein [Candida albicans] [gi:11094021]
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30
[SID26732645]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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31
[SID26732645]
 Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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32
[SID26732645]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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33
[SID26732645]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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34
[SID26732645]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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35
[SID26732645]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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36
[SID26732645]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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37
[SID26732645]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Polyadenylation [AID1875, Type: screening]
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38
[SID26732645]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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39
[SID26732645]
 Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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40
[SID26732645]
Conc @ Max Fold Increase A high-throughput screen to identify small molecule compounds that augment HSV replication [AID1956, Type: confirmatory]
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41
[SID26732645]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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42
[SID26732645]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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43
[SID26732645]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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44
[SID26732645]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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45
[SID26732645]
 uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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46
[SID26732645]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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47
[SID26732645]
 HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells. [AID1377, Type: screening]
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48
[SID26732645]
 HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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49
[SID26732645]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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50
[SID26732645]
EC50 Screen for small molecule probes relevant to Friedreich's ataxia, Single Dose and Dose Response [AID1465, Type: confirmatory]
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