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mycophenolate mofetil (CID 5281078) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(47)
 
 
Inconclusive(30)
 
 
Unspecified(138)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(17)
 
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD PPAR(8)
 
 
 
 
BioAssay Types:
Confirmatory(67)
 
 
 
 
Summary(24)
 
 
 
 
Literature(9)
 
 
 
Screening(2)
 
 
BioActivity Types:
IC50(116)
 
 
Potency(85)
 
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 240    Data Row: 241   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144205239]
Potency-Replicate_1 0.1059qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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2
[SID144205239]
Potency 0.1334qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID144205239]
Ratio Potency (uM) 0.141232qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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4
[SID144205239]
Potency 0.1679qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID144205239]
Ratio Potency (uM) 0.213138qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144205239]
Potency-Replicate_1 0.4216qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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7
[SID144205239]
Potency-Replicate_1 0.4216qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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8
[SID144205239]
Potency-Replicate_1 0.5308qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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9
[SID144205239]
Potency-Replicate_1 0.674qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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10
[SID144205239]
Potency-Replicate_1 0.9439qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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11
[SID170464859]
Ratio Potency (uM) 1.05901qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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12
[SID144205239]
Potency 1.122qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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13
[SID144205239]
Potency 1.122qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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14
[SID170464859]
Potency-Replicate_1 1.6784qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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15
[SID144205239]
Potency-Replicate_1 1.6785qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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16
[SID170464859]
Potency-Replicate_1 2.9847qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743215, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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17
[SID144205239]
Potency-Replicate_1 3.378qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID103524891]
EC50 7Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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19
[SID144205239]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID170464859]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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21
[SID170464859]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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22
[SID48416299]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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23
[SID103524891]
Efficacy against Freund's complete adjuvant-induced arthritis in Lewis rat assessed as inhibition of paw swelling at 15 mg/kg, po after 21 days [AID292070, Type: Literature]
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24
[SID103524891]
Gastrointestinal toxicity in Lewis rat adjuvant arthritis model [AID292071, Type: Literature]
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25
[SID103524891]
Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor [AID742508, Type: other]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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26
[SID103524891]
Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor [AID742508, Type: other]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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27
[SID103524891]
EC50 50Cytotoxicity against BESM cells after 88 hrs by HTS assay [AID547621, Type: Literature]
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28
[SID103524891]
Selectivity window, ratio of EC50 for BESM cells to EC50 for Trypanosoma cruzi amastigotes infected in BESM cells [AID547804, Type: Literature]
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29
[SID103524891]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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30
[SID103524891]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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31
[SID103524891]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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32
[SID103524891]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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33
[SID103524891]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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34
[SID103524891]
IC50 DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) [AID625193, Type: other]Acetylcholinesterase [gi:113037]
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35
[SID103524891]
IC50 DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: other]Muscarinic acetylcholine receptor M1 [gi:113118]
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36
[SID103524891]
IC50 DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: other]Muscarinic acetylcholine receptor M2 [gi:113122]
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37
[SID103524891]
IC50 DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M3 [gi:113125]
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38
[SID103524891]
IC50 DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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39
[SID103524891]
IC50 DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) [AID625150, Type: other]Amine oxidase [flavin-containing] A [gi:113978]
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40
[SID103524891]
IC50 DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: other]Carbonic anhydrase 2 [gi:115456]
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41
[SID103524891]
IC50 DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) [AID625235, Type: other]Cannabinoid receptor 1 [gi:115562]
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42
[SID103524891]
IC50 DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) [AID625175, Type: other]Cathepsin G [gi:115725]
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43
[SID103524891]
IC50 DRUGMATRIX: Peptidase, Matrix Metalloproteinase-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625177, Type: other]Interstitial collagenase [gi:116852]
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44
[SID103524891]
IC50 DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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45
[SID103524891]
IC50 DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625250, Type: other]Cytochrome P450 2E1 [gi:117250]
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46
[SID103524891]
IC50 DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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47
[SID103524891]
IC50 DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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48
[SID103524891]
DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) [AID625176, Type: other]Neutrophil elastase [gi:119292]
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49
[SID103524891]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625186, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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50
[SID103524891]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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