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stearic acid (CID 5281) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(520)
 
 
Inconclusive(54)
 
 
Unspecified(21)
 
 
Top Targets:
NR LBD PPAR(34)
 
 
 
NR LBD AR(25)
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD VDR(17)
 
 
 
NR LBD TR(17)
 
 
 
BioAssay Types:
Confirmatory(401)
 
 
 
 
Literature(101)
 
 
 
 
 
Summary(72)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(417)
 
 
 
 
IC50(7)
 
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 311    Data Row: 602   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210879]
Potency-Replicate_1 0.6113qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144210879]
Potency-Replicate_1 8.7076qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144210879]
Ratio Potency (uM) 18.058qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID17389656]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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5
[SID17389656]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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6
[SID46392135]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, 1.4 Angstroms Structural Studies On Human Muscle Fatty Acid Binding Protein: Binding Interactions With Three Saturated And Unsaturated C18 Fatty Acids [gi:157831353]
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7
[SID46392137]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, 1.4 Angstroms Structural Studies On Human Muscle Fatty Acid Binding Protein: Binding Interactions With Three Saturated And Unsaturated C18 Fatty Acids [gi:157831355]
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8
[SID103224646]
LD50 10Cytotoxicity against mouse RAW264.7 cells [AID627981, Type: Literature]
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9
[SID103224646]
Kd 80Binding affinity against Adipocyte lipid binding protein [AID32788, Type: Literature]
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10
[SID103224646]
IC50 200Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay [AID478133, Type: Literature]
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11
[SID103224646]
IC50 200Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay [AID478134, Type: Literature]
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12
[SID103224646]
MIC 300Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks [AID422404, Type: Literature]
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13
[SID103224646]
IC50 500Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid [AID360928, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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14
[SID103224646]
IC50 500Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid [AID360927, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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15
[SID103224646]
IC50 5270Binding affinity to Vibrio cholerae cholera toxin assessed as inhibition of cholera toxin binding to ganglioside GM1 receptor treated 15 mins before receptor addition by ELISA [AID423126, Type: Literature]
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16
[SID26753067]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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17
[SID103224646]
Antioxidant activity assessed as formazan formation induced absorbance changes at 25 ppm at 570 nm at 37 degC for 6 hrs by MTT assay [AID492140, Type: Literature]
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18
[SID103224646]
Antibacterial activity against Staphylococcus aureus by broth microdilution method [AID597407, Type: Literature]
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19
[SID103224646]
Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method [AID597408, Type: Literature]
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20
[SID103224646]
Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined at 2 x 10E-4 M [AID40631, Type: Literature]
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21
[SID17389656]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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22
[SID103224646]
The compound was tested for 50% growth inhibition against Crithidia fasciculata; 10-20% stimulation of growth at 30-100 uM [AID54698, Type: Literature]
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23
[SID103224646]
Cytotoxicity against mouse RAW264.7 cells at 5 uM [AID627980, Type: Literature]
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24
[SID103224646]
Antibacterial activity against Mycobacterium smegmatis mc2 155 after 72 hrs by MTT assay [AID658437, Type: Literature]
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25
[SID103224646]
Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis mc2 155 assessed as modulation of EtBr-mediated antibacterial activity measuring ratio of EtBr MIC to EtBr and compound MIC at 64 mg/L after 72 hrs by MTT assay [AID658438, Type: Literature]
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26
[SID103224646]
Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis mc2 155 assessed as modulation of isoniazid-mediated antibacterial activity measuring ratio of isoniazid MIC to isoniazid and compound MIC at 64 mg/L after 72 hrs by MTT assay [AID658441, Type: Literature]
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27
[SID144204705]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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28
[SID103224646]
Inhibition of aromatase in human placental microsomes at 20 ug/ml by radiometric method relative to control [AID376615, Type: Literature]Aromatase [gi:117293]
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29
[SID17389656]
Potency 10qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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30
[SID144204705]
Potency-Replicate_1 37.578qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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31
[SID144209085]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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32
[SID144204705]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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33
[SID144210879]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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34
[SID144210879]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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35
[SID144209085]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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36
[SID26753067]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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37
[SID26753067]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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38
[SID26753067]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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39
[SID103224646]
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627879, Type: Literature]DNA polymerase kappa [gi:59798438]
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40
[SID103224646]
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627876, Type: Literature]DNA polymerase kappa [gi:59798438]
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41
[SID26753067]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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42
[SID26753067]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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43
[SID17389656]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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44
[SID26753067]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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45
[SID26753067]
Potency qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation [AID492961, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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46
[SID144204705]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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47
[SID144204705]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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48
[SID17389656]
qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]tRNA threonylcarbamoyladenosine biosynthesis protein TsaE [gi:84028058]
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49
[SID144204705]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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50
[SID144204705]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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