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Genistein (CID 5280961) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(320)
 
 
Inactive(1320)
 
 
Inconclusive(239)
 
 
Unspecified(493)
 
 
Top Targets:
NR LBD ER(91)
 
 
 
 
 
7TM GPCR Srx(45)
 
 
 
 
NR LBD PPAR(36)
 
 
 
 
 
p450(33)
 
 
 
 
 
7TM GPCR Srsx(33)
 
 
 
 
BioAssay Types:
Confirmatory(1031)
 
 
 
 
 
Literature(631)
 
 
 
 
 
Screening(430)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(877)
 
 
 
 
 
IC50(298)
 
 
 
 
 
EC50(28)
 
 
 
 
Ki(9)
 
 
 
Kd(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1675    Data Row: 2372   Total Pages: 48   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166132]
IC50 0.0013Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cells [AID257300, Type: Literature]Estrogen receptor beta [gi:6166154]
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2
[SID103166132]
EC50 0.0017Agonist activity in transcriptional activation assay in SH-SY5Y neuroblastoma cells expressing Estrogen receptor beta [AID70506, Type: Literature]Estrogen receptor beta [gi:6166154]
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3
[SID103166132]
IC50 0.00288DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) [AID625259, Type: other]Estrogen receptor beta [gi:6166154]
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4
[SID103166132]
IC50 0.004Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay [AID70514, Type: Literature]
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5
[SID103166132]
EC50 0.0041Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
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6
[SID103166132]
EC50 0.006Transcriptional potency (EC50) at Human estrogen receptor Beta [AID70021, Type: Literature]
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7
[SID103166132]
IC50 0.0068Displacement of [3H]17beta-estradiol from recombinant human ERbeta [AID300319, Type: Literature]Estrogen receptor beta [gi:6166154]
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8
[SID103166132]
IC50 0.0097Inhibition of [3H]17-beta-estradiol binding to human estrogen receptor beta expressed in Escherichia coli [AID242135, Type: Literature]Estrogen receptor beta [gi:6166154]
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9
[SID103166132]
IC50 0.0097Inhibition of human ERbeta by radioligand binding assay [AID293384, Type: Literature]Estrogen receptor beta [gi:6166154]
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10
[SID103166132]
IC50 0.0097Inhibition of human LBD of of ERalpha [AID292714, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103166132]
IC50 0.01Binding affinity towards human estrogen receptor beta (ERbeta) [AID70520, Type: Literature]
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12
[SID103166132]
IC50 0.01Binding affinity for human Estrogen receptor beta [AID254777, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103166132]
IC50 0.01Binding affinity for human Estrogen receptor beta [AID241825, Type: Literature]Estrogen receptor beta [gi:6166154]
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14
[SID103166132]
IC50 0.01Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand [AID242353, Type: Literature]Estrogen receptor beta [gi:6166154]
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15
[SID103166132]
IC50 0.01Inhibition of human ERalpha [AID307629, Type: Literature]Steroid hormone receptor ERR1 [gi:215274146]
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16
[SID103166132]
IC50 0.018Displacement of [3H]estradiol from human recombinant ERbeta [AID361463, Type: Literature]Estrogen receptor beta [gi:6166154]
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17
[SID103166132]
EC50 0.02Transcriptional potency (EC50) at Human estrogen receptor alpha [AID223390, Type: Literature]
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18
[SID103166132]
Ki 0.024Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta [AID70660, Type: Literature]
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19
[SID103166132]
IC50 0.025Displacement of [3H]E2 from human recombinant ERbeta LBD by SPA [AID274384, Type: Literature]Estrogen receptor beta [gi:6166154]
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20
[SID103166132]
EC50 0.028Agonist activity at human ERbeta expressed in yeast AH109 by yeast two hybrid assay [AID300322, Type: Literature]Estrogen receptor beta [gi:6166154]
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21
[SID103166132]
EC50 0.028Negative ionotropic activity against potassium-induced contraction in guinea pig left atrium assessed as decrease atrial rate [AID611945, Type: Literature]
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22
[SID103166132]
IC50 0.0294Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cells [AID257299, Type: Literature]Estrogen receptor [gi:544257]
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23
[SID103166132]
EC50 0.048Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
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24
[SID103166132]
IC50 0.061Displacement of [3H]estrone from ER beta [AID262948, Type: Literature]Estrogen receptor beta [gi:6166154]
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25
[SID103166132]
EC50 0.073Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay [AID262953, Type: Literature]Estrogen receptor beta [gi:6166154]
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26
[SID103166132]
IC50 0.083Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta [AID70654, Type: Literature]
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27
[SID103166132]
IC50 0.092Binding affinity against human estrogen receptor alpha in competitive binding assay [AID70199, Type: Literature]
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28
[SID103166132]
IC50 0.0987Binding affinity for human Estrogen receptor beta [AID240680, Type: Literature]Estrogen receptor beta [gi:6166154]
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29
[SID103166132]
IC50 0.135DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
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30
[SID103166132]
EC50 0.2Ability to activate estrogen receptor 2-mediated transcription. [AID70504, Type: Literature]
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31
[SID103166132]
EC50 0.2Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta. [AID70507, Type: Literature]
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32
[SID103166132]
IC50 0.3Displacement of [3H]estradiol from human recombinant ERalpha [AID356892, Type: Literature]Estrogen receptor [gi:544257]
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33
[SID103166132]
IC50 0.34Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidase [gi:215273968]
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34
[SID103166132]
I50 0.365Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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35
[SID103166132]
Ki 0.37Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha [AID70353, Type: Literature]
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36
[SID103166132]
IC50 0.39Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement. [AID70515, Type: Literature]
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37
[SID103166132]
IC50 0.395Binding affinity towards human estrogen receptor alpha(ERalpha) [AID70319, Type: Literature]
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38
[SID103166132]
IC50 0.395Inhibition of human ERalpha by radioligand binding assay [AID293385, Type: Literature]Estrogen receptor [gi:544257]
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39
[SID103166132]
IC50 0.395Inhibition of [3H]17-beta-estradiol binding to human estrogen receptor alpha expressed in Escherichia coli [AID242151, Type: Literature]Estrogen receptor [gi:544257]
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40
[SID103166132]
IC50 0.395Inhibitory concentration against human ER alpha expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand [AID242369, Type: Literature]Estrogen receptor [gi:544257]
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41
[SID103166132]
IC50 0.395Binding affinity for human Estrogen receptor alpha [AID241852, Type: Literature]Estrogen receptor [gi:544257]
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42
[SID103166132]
IC50 0.395Binding affinity for human Estrogen receptor alpha [AID254783, Type: Literature]Estrogen receptor [gi:544257]
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43
[SID103166132]
IC50 0.395Inhibition of human ERbeta [AID307630, Type: Literature]Steroid hormone receptor ERR2 [gi:374095385]
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44
[SID103166132]
IC50 0.395Inhibition of human LBD of ERbeta [AID292715, Type: Literature]Estrogen receptor beta [gi:6166154]
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45
[SID26752076]
Potency 0.3981qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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46
[SID103166132]
IC50 0.51Estrogenic activity in human Ishikawa cells assessed as induction of alkaline phosphatase activity after 4 days by para-nitrophenol release assay [AID361464, Type: Literature]
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47
[SID103166132]
IC50 0.58Displacement of [3H]17beta-estradiol from recombinant human ERalpha [AID300318, Type: Literature]Estrogen receptor [gi:544257]
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48
[SID103166132]
EC50 0.81Agonist activity at human ERalpha expressed in yeast AH109 by yeast two hybrid assay [AID300321, Type: Literature]Estrogen receptor [gi:544257]
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49
[SID144208626]
Potency-Replicate_1 0.8486qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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50
[SID26665855]
Potency 0.8913qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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