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Genistein (CID 5280961) - Compound BioActivity Data
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BioActivity Outcomes:
Active(336)
 
 
Inactive(1350)
 
 
Inconclusive(222)
 
 
Unspecified(767)
 
 
Top Targets:
NR LBD ER(93)
 
 
 
 
 
7TM GPCR Srx(45)
 
 
 
 
NR LBD PPAR(36)
 
 
 
 
 
p450(33)
 
 
 
 
 
7TM GPCR Srsx(33)
 
 
 
 
BioAssay Types:
Confirmatory(1150)
 
 
 
 
 
Literature(673)
 
 
 
 
 
Screening(433)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(882)
 
 
 
 
 
IC50(306)
 
 
 
 
 
EC50(28)
 
 
 
 
Ki(12)
 
 
 
 
Kd(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1965    Data Row: 2675   Total Pages: 134   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166132]
IC50 0.0013Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cells [AID257300, Type: Literature]Estrogen receptor beta [gi:6166154]
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2
[SID103166132]
EC50 0.0017Agonist activity in transcriptional activation assay in SH-SY5Y neuroblastoma cells expressing Estrogen receptor beta [AID70506, Type: Literature]Estrogen receptor beta [gi:6166154]
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3
[SID103166132]
IC50 0.00288DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) [AID625259, Type: confirmatory]Estrogen receptor beta [gi:6166154]
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4
[SID103166132]
IC50 0.004Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay [AID70514, Type: Literature]
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5
[SID103166132]
EC50 0.0041Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
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6
[SID103166132]
EC50 0.006Transcriptional potency (EC50) at Human estrogen receptor Beta [AID70021, Type: Literature]
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7
[SID103166132]
IC50 0.0068Displacement of [3H]17beta-estradiol from recombinant human ERbeta [AID300319, Type: Literature]Estrogen receptor beta [gi:6166154]
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8
[SID46393531]
IC50 0.009Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Estrogen Receptor Alpha Complexed With Genistein [gi:61680313]
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9
[SID46393531]
IC50 0.009Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Estrogen Receptor Alpha Complexed With Genistein [gi:61680313]
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10
[SID103166132]
IC50 0.0097Inhibition of human ERbeta by radioligand binding assay [AID293384, Type: Literature]Estrogen receptor beta [gi:6166154]
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11
[SID103166132]
IC50 0.0097Inhibition of [3H]17-beta-estradiol binding to human estrogen receptor beta expressed in Escherichia coli [AID242135, Type: Literature]Estrogen receptor beta [gi:6166154]
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12
[SID103166132]
IC50 0.0097Inhibition of human LBD of of ERalpha [AID292714, Type: Literature]Estrogen receptor [gi:544257]
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13
[SID103166132]
IC50 0.01Binding affinity for human Estrogen receptor beta [AID241825, Type: Literature]Estrogen receptor beta [gi:6166154]
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14
[SID103166132]
IC50 0.01Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand [AID242353, Type: Literature]Estrogen receptor beta [gi:6166154]
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15
[SID103166132]
IC50 0.01Binding affinity for human Estrogen receptor beta [AID254777, Type: Literature]Estrogen receptor beta [gi:6166154]
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16
[SID103166132]
IC50 0.01Inhibition of human ERalpha [AID307629, Type: Literature]Steroid hormone receptor ERR1 [gi:215274146]
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17
[SID103166132]
IC50 0.01Binding affinity towards human estrogen receptor beta (ERbeta) [AID70520, Type: Literature]
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18
[SID103166132]
IC50 0.018Displacement of [3H]estradiol from human recombinant ERbeta [AID361463, Type: Literature]Estrogen receptor beta [gi:6166154]
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19
[SID103166132]
EC50 0.02Transcriptional potency (EC50) at Human estrogen receptor alpha [AID223390, Type: Literature]
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20
[SID103166132]
Ki 0.024Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta [AID70660, Type: Literature]
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