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alpha-Linolenic Acid (CID 5280934) - Compound BioActivity Data
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BioActivity Outcomes:
Active(95)
 
 
Inactive(952)
 
 
Inconclusive(268)
 
 
Unspecified(43)
 
 
Top Targets:
NR LBD PPAR(29)
 
 
 
 
 
NR LBD ER(23)
 
 
 
NR LBD AR(23)
 
 
 
NR LBD TR(21)
 
 
 
 
7TM GPCR Srx(19)
 
 
BioAssay Types:
Confirmatory(618)
 
 
 
 
 
Screening(343)
 
 
 
 
Literature(150)
 
 
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(601)
 
 
 
 
 
IC50(28)
 
 
 
 
 
EC50(4)
 
 
Kd(2)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 776    Data Row: 1358   Total Pages: 68   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167706]
Kd 0.0079Binding affinity to PPAR-alpha (unknown origin) by fluorescence-based assay [AID1094405, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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2
[SID17388945]
Potency 0.1259qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase, partial [Homo sapiens] [gi:1832253]
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3
[SID103167706]
IC50 1.2Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay [AID1114584, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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4
[SID103167706]
IC50 1.2Inhibition of PPAR-alpha (unknown origin) by SPA assay [AID1094404, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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5
[SID29215108]
Potency 1.7783qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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6
[SID103167706]
Kd 2Binding affinity to PPARgamma [AID677050, Type: Literature]
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7
[SID103167706]
EC50 2.6Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay [AID347386, Type: Literature]Free fatty acid receptor 4 [gi:82581671]
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8
[SID103167706]
EC50 2.88403Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay [AID673112, Type: Literature]
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9
[SID29215108]
Potency 3.1623qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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10
[SID103167706]
EC50 3.23594Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay [AID673111, Type: Literature]
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11
[SID17388945]
Potency 3.5481qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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12
[SID103167706]
Ki 4Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method [AID1053273, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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13
[SID29215108]
Potency 5.0119qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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14
[SID103167706]
EC50 5.2Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay [AID347387, Type: Literature]Free fatty acid receptor 1 [gi:3122157]
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15
[SID103167706]
IC50 6Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay [AID1114583, Type: confirmatory]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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16
[SID57260459]
Potency 7.9433qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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17
[SID57260459]
Potency 9.4662qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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18
[SID50105513]
Potency 10qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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19
[SID29215108]
Potency 10qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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20
[SID103167706]
IC50 12Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid [AID360927, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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