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Leukotriene E4 (CID 5280879) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(32)
 
 
Inconclusive(1)
 
 
Unspecified(5)
 
 
Top Targets:
ABCC MRP doma..(4)
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Confirmatory(33)
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(30)
 
 
 
EC50(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 38    Data Row: 39   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103591347]
EC50 0.0013Agonist activity at human P2Y12 receptor [AID431380, Type: Literature]P2Y purinoceptor 12 [gi:21263835]
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2
[SID103591347]
IC50 9.83TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells [AID681600, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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3
[SID103591347]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681342, Type: Literature]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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4
[SID103591347]
Activity at MRP1 in human HeLa T5 cells assessed as ATP-dependent drug transport at 50 nM measured per mg of protein [AID370722, Type: Literature]Multidrug resistance-associated protein 1 [gi:296439301]
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5
[SID103591347]
Km TP_TRANSPORTER: uptake in membrane vesicle from MRP1-expressing HeLa cells [AID681351, Type: Literature]Multidrug resistance-associated protein 1 [gi:296439301]
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6
[SID103591347]
Km TP_TRANSPORTER: uptake in liver plasma membrane vesicles of Wistar rat [AID678989, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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7
[SID26756770]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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8
[SID26756770]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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9
[SID26756770]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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10
[SID26756770]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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11
[SID26756770]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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12
[SID26756770]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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13
[SID26756770]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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14
[SID26756770]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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15
[SID26756770]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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16
[SID26756770]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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17
[SID26756770]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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18
[SID26756770]
Potency qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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19
[SID26756770]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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20
[SID26756770]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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