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Leukotriene D4 (CID 5280878) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(32)
 
 
Unspecified(8)
 
 
Top Targets:
7tm 4(4)
 
 
 
ABCC MRP doma..(4)
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
BioAssay Types:
Confirmatory(33)
 
 
 
Literature(9)
 
 
 
BioActivity Types:
Potency(30)
 
 
 
IC50(3)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 43    Data Row: 44   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103214066]
Ki 0.0006Displacement of [3H]LTD4 from LTD4 receptor [AID338157, Type: Literature]
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2
[SID103214066]
IC50 0.0007Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins [AID751668, Type: Literature]Cysteinyl leukotriene receptor 1 [gi:20138087]
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3
[SID103214066]
IC50 0.007Inhibition of human leukotriene D4 receptor [AID566263, Type: Literature]Cysteinyl leukotriene receptor 1 [gi:20138087]
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4
[SID26756769]
Potency 26.6795Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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5
[SID103214066]
Km 1.5TP_TRANSPORTER: uptake in liver plasma membrane vesicles of Wistar rat [AID678989, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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6
[SID103214066]
IC50 5.48TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells [AID681600, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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7
[SID103214066]
Compound was evaluated for its agonist activity on guinea-pig ileum, value expressed as the negative logarithm of the ED50 value [AID79668, Type: other]
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8
[SID103214066]
Displacement of [3H]LTD4 from LTD4 receptor assessed as specific binding relative to total binding [AID338194, Type: Literature]
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9
[SID103214066]
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells at 10 uM after 30 mins relative to control [AID751732, Type: Literature]Cysteinyl leukotriene receptor 1 [gi:20138087]
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10
[SID103214066]
Compound was evaluated for its binding affinity on guinea-pig ileum [AID101454, Type: other]Cysteinyl leukotriene receptor 1 [gi:123779610]
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11
[SID103214066]
Activity at MRP1 in human HeLa T5 cells assessed as ATP-dependent drug transport at 50 nM measured per mg of protein [AID370722, Type: Literature]Multidrug resistance-associated protein 1 [gi:296439301]
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12
[SID103214066]
Km TP_TRANSPORTER: uptake in membrane vesicle from MRP1-expressing HeLa cells [AID681351, Type: Literature]Multidrug resistance-associated protein 1 [gi:296439301]
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13
[SID26756769]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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14
[SID26756769]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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15
[SID26756769]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID26756769]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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17
[SID26756769]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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18
[SID26756769]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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19
[SID26756769]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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20
[SID26756769]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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