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kaempferol (CID 5280863) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(165)
 
 
Inactive(849)
 
 
Inconclusive(152)
 
 
Unspecified(204)
 
 
Top Targets:
NR LBD PPAR(33)
 
 
 
 
 
p450(21)
 
 
 
 
NR LBD AR(20)
 
 
 
 
 
NR LBD ER(20)
 
 
 
 
 
NR LBD TR(18)
 
 
 
BioAssay Types:
Confirmatory(573)
 
 
 
 
 
Screening(364)
 
 
 
Literature(315)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(500)
 
 
 
 
 
IC50(90)
 
 
 
 
 
EC50(9)
 
 
 
 
Ki(8)
 
 
 
AC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1059    Data Row: 1370   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103206920]
IC50 0.028Inhibition of aryl hydrocarbon receptor [AID311070, Type: Literature]
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2
[SID103206920]
Ki 0.043Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
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3
[SID103206920]
IC50 0.047Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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4
[SID144213678]
Potency-Replicate_1 0.3278qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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5
[SID103206920]
IC50 0.36Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406997, Type: Literature]Estradiol 17-beta-dehydrogenase 2 [gi:544152]
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6
[SID103206920]
IC50 0.632Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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7
[SID103206920]
IC50 0.716Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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8
[SID103206920]
Ki 0.75Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
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9
[SID103206920]
IC50 0.84Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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10
[SID103206920]
IC50 1.05Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406995, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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11
[SID103206920]
IC50 1.06Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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12
[SID144213678]
Ratio Potency (uM) 1.16291qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID103206920]
IC50 1.2Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay [AID510244, Type: Literature]
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14
[SID103206920]
ID50 1.22Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: Literature]
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15
[SID49674535]
AC50_uM 1.259MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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16
[SID103206920]
ID50 1.29Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: Literature]
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17
[SID103206920]
IC50 1.33Inhibition of rat lens aldose reductase [AID385353, Type: Literature]Aldose reductase [gi:1168407]
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18
[SID11112381]
Potency 1.5849qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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19
[SID103206920]
IC50 1.6Induction of mouse osteoclast apoptosis [AID311864, Type: Literature]
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20
[SID103206920]
IC50 1.7Inhibition of beta amyloid (1 to 40) fibril formation by thioflavin T staining-based binding assay [AID456188, Type: Literature]
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21
[SID103206920]
IC50 2.2Inhibition of 15LOX in rabbit reticulocytes by EIA assay [AID286229, Type: Literature]Arachidonate 15-lipoxygenase [gi:126397]
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22
[SID103206920]
IC50 2.32Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay [AID730328, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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23
[SID103206920]
Ki 2.4Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay [AID427748, Type: Literature]
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24
[SID103206920]
IC50 2.7Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
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25
[SID103206920]
IC50 2.7Inhibition of 5LOX in human PBMC by EIA assay [AID286228, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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26
[SID103206920]
IC50 3.2Inhibition of beta amyloid (1 to 42) fibril formation by thioflavin T staining-based binding assay [AID456189, Type: Literature]
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27
[SID103206920]
GI50 3.34Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay [AID730327, Type: Literature]
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28
[SID103206920]
IC50 3.5Inhibition of glycogen synthase kinase 3 [AID240981, Type: Literature]
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29
[SID144208363]
Potency-Replicate_1 3.8414qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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30
[SID103206920]
IC50 4Inhibition of FabG [AID265760, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
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31
[SID103206920]
IC50 4.7Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [AID578759, Type: Literature]
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32
[SID17389844]
Potency 5.308qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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33
[SID144208363]
Ratio Potency (uM) 5.63839qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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34
[SID103206920]
Ki 6Binding affinity towards cytochrome P450 2C9 [AID54410, Type: Literature]
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35
[SID103206920]
IC50 6.2Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining [AID578760, Type: Literature]
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36
[SID46501187]
Potency 6.3096qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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37
[SID103206920]
Kd 6.7Binding affinity to nucleotide-binding domain (NBD2) of P-Glycoprotein [AID150741, Type: Literature]Multidrug resistance protein 1A [gi:239938877]
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38
[SID103206920]
Kd 6.76083Binding affinity to ABCB1 nucleotide binding domain 2 [AID615921, Type: Literature]
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39
[SID17389844]
Potency 7.9433qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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40
[SID103206920]
IC50 8Inhibition of Clostridium perfringens neuraminidase [AID455702, Type: Literature]Sialidase [gi:127825]
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41
[SID17389844]
Potency 8.4127qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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42
[SID26757741]
Potency 8.9125qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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43
[SID103206920]
IC50 9.7Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay [AID429119, Type: Literature]Androgen receptor [gi:113830]
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44
[SID46501187]
IC50 9.933Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay [AID540297, Type: confirmatory]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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45
[SID11112381]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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46
[SID103206920]
IC50 10Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry [AID639825, Type: Literature]Aldose reductase [gi:113596]
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47
[SID103206920]
IC50 10.4Inhibition of duck liver FASN [AID697064, Type: Literature]
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48
[SID103206920]
IC50 11.2Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase [AID455703, Type: Literature]
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49
[SID46501187]
EC50_uM 11.59Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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50
[SID144213678]
Potency-Replicate_1 11.6291qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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