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Cholecalciferol (CID 5280795) - Compound BioActivity Data
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BioActivity Outcomes:
Active(216)
 
 
Inactive(233)
 
 
Inconclusive(185)
 
 
Unspecified(349)
 
 
Top Targets:
7tm 4(33)
 
 
 
NR LBD VDR(26)
 
 
 
 
 
NR LBD ER(19)
 
 
 
 
 
NR LBD AR(17)
 
 
 
 
 
NR LBD PPAR(15)
 
 
 
 
BioAssay Types:
Confirmatory(451)
 
 
 
 
 
Literature(127)
 
 
 
 
 
Summary(39)
 
 
 
 
Screening(9)
 
 
 
BioActivity Types:
Potency(324)
 
 
 
 
IC50(124)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 646    Data Row: 983   Total Pages: 50   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103279849]
IC50 2.1Inhibition of Hedgehog signaling in mouse ASZ001 cells assessed as downregulation of Gli1 mRNA expression after 48 hrs by RT-PCR analysis [AID760017, Type: Literature]
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2
[SID103279849]
IC50 2.9Inhibition of Hedgehog signaling in mouse C3H10T1/2 cells assessed as downregulation of Ptch mRNA expression after 24 hrs by RT-PCR analysis [AID760024, Type: Literature]
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3
[SID103279849]
IC50 4.1Inhibition of Hedgehog signaling in mouse C3H10T1/2 cells assessed as downregulation of Gli1 mRNA expression after 24 hrs by RT-PCR analysis [AID760025, Type: Literature]
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4
[SID17388665]
Potency 11.2202qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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5
[SID144205131]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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6
[SID144205131]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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7
[SID144209744]
Potency-Replicate_1 15.2149qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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8
[SID26754459]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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9
[SID17388665]
Potency 15.8489qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID17388665]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase, partial [Homo sapiens] [gi:1832253]
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11
[SID144209744]
Potency-Replicate_1 19.3174qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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12
[SID144209744]
Ratio Potency (uM) 20.6824qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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13
[SID144205131]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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14
[SID144209744]
Potency-Replicate_1 21.4916qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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15
[SID26754459]
Potency 22.3872qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID103279849]
GI50 23.2Growth inhibition of human U87MG cells after 72 hrs by MTS assay [AID674346, Type: Literature]
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17
[SID17388665]
Potency 23.7101qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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18
[SID29215239]
Potency 23.715A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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19
[SID144209744]
Potency-Replicate_1 24.1139qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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20
[SID26754459]
Potency 25.1189Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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