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Stigmasterol (CID 5280794) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(10)
 
 
Unspecified(48)
 
 
Top Targets:
7TM GPCR Srsx(1)
 
 
BioAssay Types:
Literature(63)
 
 
 
 
BioActivity Types:
IC50(23)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 63    Data Row: 63   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556863]
IC50 11.14Cytotoxicity against human K562 cells after 24 hrs by MTT assay [AID674244, Type: Literature]
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2
[SID103556863]
IC50 18.28Cytotoxicity against human PC3 cells after 24 hrs by MTT assay [AID674242, Type: Literature]
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3
[SID103556863]
IC50 21.43Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay [AID674245, Type: Literature]
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4
[SID103556863]
IC50 22.73Cytotoxicity against human DU145 cells after 24 hrs by MTT assay [AID674243, Type: Literature]
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5
[SID103556863]
IC50 43.4Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay [AID356610, Type: Literature]
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6
[SID103556863]
IC50 50Cytotoxicity against human HeLa cells by MTT assay [AID424740, Type: Literature]
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7
[SID103556863]
IC50 50Cytotoxicity against mouse P388D1 cells by MTT assay [AID424741, Type: Literature]
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8
[SID103556863]
IC50 60.28Inhibition of lyase activity of DNA polymerase beta [AID328030, Type: Literature]
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9
[SID103556863]
IC50 98.2Cytotoxicity against human A549 cells after 1 hr by MTT assay [AID328033, Type: Literature]
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10
[SID103556863]
IC50 100Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting [AID360618, Type: Literature]
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11
[SID103556863]
IC50 100Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting [AID360626, Type: Literature]
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12
[SID103556863]
IC50 100Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting [AID360633, Type: Literature]
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13
[SID103556863]
IC50 100Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting [AID360640, Type: Literature]
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14
[SID103556863]
IC50 100Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting [AID360647, Type: Literature]
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15
[SID103556863]
IC50 100Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting [AID360654, Type: Literature]
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16
[SID103556863]
IC50 100Antiprotozoal activity against Plasmodium falciparum K1 [AID336443, Type: Literature]
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17
[SID103556863]
IC50 100Antitrypanosomal activity against Trypanosoma brucei brucei S427 blood stream trypomastigotes [AID336444, Type: Literature]
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18
[SID103556863]
IC50 100Cytotoxicity against human KB cells [AID336445, Type: Literature]
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19
[SID103556863]
IC50 100Antileishmanial activity against Leishmania donovani (MHOM/ET/67/L82) promastigotes [AID336446, Type: Literature]
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20
[SID103556863]
IC50 134.6Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomastigotes by alamar blue assay [AID311138, Type: Literature]
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21
[SID103556863]
IC50 242.3Cytotoxicity against mouse J774 cells by alamar blue assay [AID311139, Type: Literature]
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22
[SID103556863]
IC50 250Inhibition of polymerase activity of DNA polymerase beta [AID328031, Type: Literature]
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23
[SID103556863]
Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Trypanosoma brucei brucei bloodstream trypomastigotes [AID311143, Type: Literature]
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24
[SID103556863]
Inhibition of HIV1 RT [AID397122, Type: Literature]
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25
[SID103556863]
Cytotoxicity against human KB cells after 72 hrs [AID401104, Type: Literature]
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26
[SID103556863]
Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 2 weeks by microbroth dilution method [AID489305, Type: Literature]
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27
[SID103556863]
Cytotoxicity against human PC3 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay [AID674246, Type: Literature]
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28
[SID103556863]
Cytotoxicity against human K562 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay [AID674247, Type: Literature]
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29
[SID103556863]
Cytotoxicity against human MCF7 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay [AID674248, Type: Literature]
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30
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as early apoptotic cells at 10 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674252, Type: Literature]
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31
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 10 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674253, Type: Literature]
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32
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as necrotic cells at 10 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674254, Type: Literature]
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33
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as early apoptotic cells at 20 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674255, Type: Literature]
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34
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 20 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674256, Type: Literature]
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35
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as necrotic cells at 20 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674257, Type: Literature]
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36
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as early apoptotic cells at 40 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674261, Type: Literature]
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37
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 40 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674262, Type: Literature]
View
38
[SID103556863]
Induction of apoptosis in human PC3 cells assessed as necrotic cells at 40 uM after 48 hrs by annexinV/propidium iodide staining-based FITC analysis relative to control [AID674263, Type: Literature]
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39
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at G0/G1 phase at 10 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674297, Type: Literature]
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40
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at S phase at 10 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674298, Type: Literature]
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41
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase at 10 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674299, Type: Literature]
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42
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at G0/G1 phase at 20 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674300, Type: Literature]
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43
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at S phase at 20 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674301, Type: Literature]
View
44
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase at 20 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674302, Type: Literature]
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45
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at G0/G1 phase at 40 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674306, Type: Literature]
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46
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at S phase at 40 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674307, Type: Literature]
View
47
[SID103556863]
Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase at 40 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis relative to control [AID674308, Type: Literature]
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48
[SID103556863]
Antibacterial activity against Bacillus subtilis ATCC 6633 after 48 hrs by silica gel plate-based INT-formazan method [AID337692, Type: Literature]
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49
[SID103556863]
Antibacterial activity against Escherichia coli ATCC 25922 after 48 hrs by silica gel plate-based INT-formazan method [AID337693, Type: Literature]
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50
[SID103556863]
Antiviral activity against Parainfluenza virus type 3 infected in human Hep2 cells assessed as inhibition of virus-induced cytopathogenic effect [AID357949, Type: Literature]
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