Ergocalciferols (CID 5280793) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(358)
 
 
Inconclusive(8)
 
 
Unspecified(152)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(8)
 
 
alkPPc(4)
 
 
Tryp SPc(4)
 
 
 
BioAssay Types:
Screening(266)
 
 
 
Confirmatory(93)
 
 
 
 
 
Literature(29)
 
 
 
 
BioActivity Types:
IC50(127)
 
 
 
Potency(80)
 
 
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 524    Data Row: 528   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103567215]
EC50 3.8Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay [AID323922, Type: Literature]
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2
[SID57264355]
Potency 14.1254qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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3
[SID57264355]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID57264355]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID57264355]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID144205957]
Potency 26.6086qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID144205957]
Potency 26.6086qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID144205957]
Potency 26.6086qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID103567215]
GI50 33.7Growth inhibition of human U87MG cells after 72 hrs by MTS assay [AID674346, Type: Literature]
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10
[SID103567215]
 Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 24 hrs by luciferase reporter assay [AID323928, Type: Literature]
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11
[SID103567215]
 Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/C-5B/KE/poly cells after 72 hrs by luciferase reporter assay [AID323924, Type: Literature]
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12
[SID103567215]
 Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/3-5B/KE/poly cells after 72 hrs by luciferase reporter assay [AID323925, Type: Literature]
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13
[SID10321530]
 MDR-1 [AID377, Type: other]ABCB1 gene product [Homo sapiens] [gi:42741659]
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14
[SID10321530]
 MDR-1 [AID377, Type: other]ABCB1 gene product [Homo sapiens] [gi:42741659]
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15
[SID10321530]
 MDR-1 [AID377, Type: other]ABCB1 gene product [Homo sapiens] [gi:42741659]
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16
[SID49698480]
 Vibrio cholerae assay for pro-quorum sensing small molecules [AID686977, Type: screening]cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657203]
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17
[SID103567215]
GI50 100Growth inhibition of human HT-29 cells overexpressing VDR gene after 72 hrs by MTS assay [AID674347, Type: Literature]
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18
[SID103567215]
 Down-regulation of Gli1 mRNA expression in human U87MG cells at 10 uM after 24 hrs by RT-PCR analysis relative to DMSO-treated control [AID674348, Type: Literature]
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19
[SID103567215]
 Upregulation of CYP24A1 mRNA expression in human U87MG cells at 10 uM after 24 hrs by RT-PCR analysis relative to DMSO-treated control [AID674349, Type: Literature]
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20
[SID103567215]
 Down-regulation of Gli1 mRNA expression in human HT-29 cells at 10 uM after 24 hrs by RT-PCR analysis relative to DMSO-treated control [AID674350, Type: Literature]
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21
[SID103567215]
 Upregulation of CYP24A1 mRNA expression in human HT-29 cells at 10 uM after 24 hrs by RT-PCR analysis relative to DMSO-treated control [AID674351, Type: Literature]
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22
[SID103567215]
 Ratio of CYP24A1 mRNA upregulation in human HT-19 cells to upregulation of CYP24A1 mRNA in human U87MG cells [AID674352, Type: Literature]
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23
[SID103567215]
 Cytotoxicity against human OR6 cells after 72 hrs [AID323929, Type: Literature]
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24
[SID103567215]
 Cytotoxicity against human OR6 cells after 120 hrs [AID323932, Type: Literature]
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25
[SID103567215]
 Cytotoxicity against human OR6 cells after 120 hrs by cell viability assay [AID323923, Type: Literature]
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26
[SID103567215]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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27
[SID103567215]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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28
[SID103567215]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
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29
[SID103567215]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
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30
[SID103567215]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
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31
[SID103567215]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2 [gi:543740]
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32
[SID103567215]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2 [gi:543740]
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33
[SID103567215]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2 [gi:543740]
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34
[SID103567215]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A [gi:1351831]
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35
[SID103567215]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A [gi:1351831]
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36
[SID103567215]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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37
[SID103567215]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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38
[SID103567215]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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39
[SID103567215]
IC50 DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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40
[SID103567215]
IC50 DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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41
[SID103567215]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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42
[SID103567215]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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43
[SID103567215]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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44
[SID103567215]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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45
[SID103567215]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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46
[SID103567215]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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47
[SID103567215]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
View
48
[SID103567215]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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49
[SID103567215]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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50
[SID103567215]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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