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apigetrin (CID 5280704) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(19)
 
 
Unspecified(19)
 
 
Top Targets:
crotonase-lik..(1)
 
 
Chorismate bi..(1)
 
 
23DHB-AMP lg(1)
 
 
HTH MARR(1)
 
 
Sialidase(1)
 
 
BioAssay Types:
Literature(39)
 
 
 
 
Screening(3)
 
 
BioActivity Types:
IC50(7)
 
 
 
 
EC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 49    Data Row: 49   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103582369]
GI50 0.076Growth inhibitory activity against human cancer cell line in the NCI inverted question marks anticancer drug screening program [AID247402, Type: Literature]
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2
[SID103582369]
EC50 12.3Cytoprotective activity against doxorubicin-induced cytotoxicity in rat H9c2 cells assessed as cell viability after 24 hrs by MTT assay [AID528046, Type: Literature]
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3
[SID103582369]
EC50 13.09Antioxidant activity assessed as ABTS radical scavenging activity [AID528045, Type: Literature]
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4
[SID103582369]
EC50 20.37Antioxidant activity of the compound assessed as DPPH radical scavenging activity after 30 mins [AID528043, Type: Literature]
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5
[SID103582369]
IC50 39.3Inhibition of Clostridium perfringens neuraminidase [AID455702, Type: Literature]Sialidase [gi:127825]
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6
[SID103582369]
IC50 46.9Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase [AID455703, Type: Literature]
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7
[SID103582369]
Antiestrogenic activity in human MCF7 cells assessed as drug level causing inhibition of 100 pM E2-enhanced cell proliferation to level equivalent to 50 pM E2 after 96 hrs by alamar blue assay [AID470163, Type: Literature]
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8
[SID103582369]
Antiestrogenic activity in human MCF7 cells assessed as drug level causing inhibition of 100 pM E2-enhanced cell proliferation to level equivalent to 10 pM E2 after 96 hrs by alamar blue assay [AID470164, Type: Literature]
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9
[SID103582369]
Antiestrogenic activity in human T47D cells assessed as drug level causing inhibition of 100 pM E2-enhanced cell proliferation to level equivalent to 50 pM E2 after 96 hrs by alamar blue assay [AID470166, Type: Literature]
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10
[SID103582369]
Antiestrogenic activity in human T47D cells assessed as drug level causing inhibition of 100 pM E2-enhanced cell proliferation to level equivalent to 10 pM E2 after 96 hrs by alamar blue assay [AID470167, Type: Literature]
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11
[SID103582369]
Antiestrogenic activity in human T47D cells assessed as drug level causing inhibition of 100 pM E2-enhanced cell proliferation to level equivalent to 1 pM E2 after 96 hrs by alamar blue assay [AID470168, Type: Literature]
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12
[SID103582369]
IC50 20Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method [AID469266, Type: Literature]
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13
[SID103582369]
EC50 61Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay [AID332929, Type: Literature]
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14
[SID103582369]
IC50 88.4Antioxidant activity assessed as inhibition of AAPH-induced hemolysis in rat RBC after 3 hrs [AID356014, Type: Literature]
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15
[SID103582369]
IC50 115Cytotoxicity against human H9 cells after 3 days [AID332930, Type: Literature]
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16
[SID103582369]
EC50 515100Antioxidant activity assessed as ferrous ion chelating activity [AID528044, Type: Literature]
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17
[SID103582369]
Antiestrogenic activity in human MCF7 cells assessed as drug level causing inhibition of 100 pM E2-enhanced cell proliferation to level equivalent to 1 pM E2 after 96 hrs by alamar blue assay [AID470165, Type: Literature]
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18
[SID103582369]
Antiestrogenic activity in human MCF7 cells assessed as inhibition of E2-enhanced cell proliferation at 0.1 to 100 uM after 96 hrs by alamar blue assay [AID470169, Type: Literature]
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19
[SID103582369]
Antimutagenic activity in Salmonella Typhimurium TA98 assessed as inhibition of 3-nitrofluoranthene-induced mutation by Ames test [AID515157, Type: Literature]
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20
[SID103582369]
Therapeutic index, ratio of IC50 for human H9 cells to EC50 for HIV1 3B [AID332931, Type: Literature]
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21
[SID103582369]
Cytotoxicity against human KB cells [AID404008, Type: Literature]
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22
[SID103582369]
ABTS radical scavenging activity assessed as trolox equivalent antioxidant capacity [AID456316, Type: Literature]
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23
[SID103582369]
DPPH radical scavenging activity assessed as trolox equivalent antioxidant capacity [AID456318, Type: Literature]
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24
[SID103582369]
Antimicrobial activity against Bacillus subtilis IP 5832 after 24 hrs by agar well diffusion method [AID377143, Type: Literature]
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25
[SID103582369]
Activation of guinea pig classical complement system assessed as hemolysis of sensitized sheep erythrocytes at 1000 uM [AID332705, Type: Literature]
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26
[SID103582369]
Activation of human plasma alternative complement system assessed as hemolysis of non-sensitized rabbit erythrocytes at 1000 uM [AID332707, Type: Literature]
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27
[SID103582369]
Inhibitory activity against HIV-1 IIIB replication in H9 cell line [AID78777, Type: other]
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28
[SID103582369]
Inhibitory activity against H9 cells uninfected with HIV-1 [AID78941, Type: other]
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29
[SID103582369]
Ratio of IC50 to EC50 was expressed as therapeutic index [AID235017, Type: other]
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30
[SID103582369]
Inhibition of cow milk xanthine oxidase at 50 ug/mL [AID338974, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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31
[SID92124907]
A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme BasE [AID485350, Type: screening]enterobactin synthase subunit E [Acinetobacter baumannii ATCC 17978] [gi:126642418]
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32
[SID92124907]
A screen for compounds that modulate the activity of the Staphylococcus aureus MgrA protein [AID602314, Type: other]MarR family regulatory protein [Staphylococcus aureus subsp. aureus str. Newman] [gi:151220867]
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33
[SID103582369]
IC50 Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [AID578759, Type: Literature]
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34
[SID103582369]
IC50 Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining [AID578760, Type: Literature]
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35
[SID103582369]
Inhibition of P-gp expressed in A2780adr cells at 10 uM by calcein AM accumulation assay relative to verapamil [AID578765, Type: Literature]
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36
[SID103582369]
Cytotoxicity against human A2780 cells assessed as intracellular ATP level at 10 uM after 72 hrs by luminometry [AID578843, Type: Literature]
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37
[SID103582369]
Cytotoxicity against human MCF7 cells assessed as intracellular ATP level at 10 uM after 72 hrs by luminometry [AID578844, Type: Literature]
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38
[SID103582369]
Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by agar well diffusion method [AID377146, Type: Literature]
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39
[SID103582369]
Antimicrobial activity against Aspergillus niger after 48 hrs by agar well diffusion method [AID377147, Type: Literature]
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40
[SID103582369]
Stimulation of human MCF7 cell proliferation up to 100 uM after 96 hrs by alamar blue assay relative to estradiol [AID470161, Type: Literature]
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41
[SID103582369]
Stimulation of human T47D cell proliferation up to 100 uM after 96 hrs by alamar blue assay relative to estradiol [AID470162, Type: Literature]
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42
[SID103582369]
In vivo antitumor activity against mouse S180 cells [AID404067, Type: Literature]
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43
[SID92124907]
Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection [AID720717, Type: other]ORF 73 [Human herpesvirus 8 type M] [gi:1718329]
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44
[SID92124907]
A screen for compounds that inhibit replication of Vibrio cholerae chromosome II [AID504770, Type: other]hypothetical protein VC_A0002 [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657380]
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45
[SID92124907]
A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis [AID540299, Type: Literature]Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) [Mycobacterium tuberculosis H37Rv] [gi:15607688]
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46
[SID26613151]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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47
[SID26613151]
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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48
[SID92124907]
A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities [AID588519, Type: Literature]Chain A, Poliovirus Polymerase With Gtp [gi:52695378]
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49
[SID92124907]
A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtI [AID493033, Type: other]Isochorismate synthase/isochorismate lyase [gi:81706979]
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