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Hymecromone (CID 5280567) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(45)
 
 
Inactive(770)
 
 
Inconclusive(114)
 
 
Unspecified(104)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
 
 
7TM GPCR Srx(15)
 
 
GT1 Gtf like(15)
 
 
NR LBD AR(14)
 
 
 
 
NR LBD ER(14)
 
 
 
BioAssay Types:
Confirmatory(392)
 
 
 
 
 
Screening(368)
 
 
 
 
Literature(184)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(321)
 
 
 
 
 
IC50(25)
 
 
 
 
Ki(4)
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 816    Data Row: 1033   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103173444]
Ki 0.56Inhibition of human recombinant CA9 after 6 hrs by stopped flow CO2 hydration assay [AID641825, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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2
[SID103173444]
IC50 1Inhibition of human 17beta-HSD3 expressed in HeLa cells [AID452459, Type: Literature]Testosterone 17-beta-dehydrogenase 3 [gi:1169300]
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3
[SID11112236]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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4
[SID11112236]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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5
[SID103173444]
Ki 8.1Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay [AID641826, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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6
[SID144203936]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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7
[SID144203936]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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8
[SID144203936]
Potency-Replicate_1 10qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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9
[SID11112236]
Potency 10qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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10
[SID11112236]
Potency 10qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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11
[SID144203936]
Potency-Replicate_1 11.2202qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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12
[SID103173444]
IC50 24.5Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis [AID516862, Type: Literature]Aldose reductase [gi:113596]
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13
[SID170465819]
Potency-Replicate_1 26.6011qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743212, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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14
[SID170465819]
Potency-Replicate_1 29.847qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743220, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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15
[SID144211232]
Potency-Replicate_1 30.6379qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144211232]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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17
[SID144211232]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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18
[SID144211232]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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19
[SID144211232]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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20
[SID144211232]
Potency-Replicate_1 43.6412qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743212, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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21
[SID144211232]
Potency-Replicate_1 43.6412qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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22
[SID144211232]
Potency-Replicate_1 48.9662qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743094, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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23
[SID144211232]
Potency-Replicate_1 48.9662qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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24
[SID47193740]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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25
[SID144211232]
Potency-Replicate_1 54.941qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743220, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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26
[SID144211232]
Ratio Potency (uM) 61.1306qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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27
[SID144211232]
Potency-Replicate_1 61.1306qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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28
[SID11112236]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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29
[SID11112236]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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30
[SID11112236]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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31
[SID47193740]
Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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32
[SID47193740]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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33
[SID47193740]
Rml C and D fluorescent artifact dose-response confirmation [AID1696, Type: confirmatory]dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase) [Mycobacterium tuberculosis H37Rv] [gi:15610601]
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34
[SID47193740]
Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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35
[SID47193740]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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36
[SID47193740]
Rml C and D fluorescent artifact dose-response confirmation [AID1696, Type: confirmatory]dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rhamnose synthase) [Mycobacterium tuberculosis H37Rv] [gi:15610402]
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37
[SID11112236]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_61, Type: Literature]
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38
[SID11112236]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
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39
[SID11112236]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_51, Type: Literature]
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40
[SID103173444]
Induction of cell differentiation in human U937 cells assessed as increase of CD11b and CD14 expression at 500 uM after 72 hrs by FACS flow cytometer analysis [AID715783, Type: Literature]
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41
[SID47193740]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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42
[SID11112236]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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43
[SID11112236]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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44
[SID47193740]
Rml C and D inhibition 384-well mixture HTS [AID1532, Type: screening]
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45
[SID103173444]
Effect on DNA fragmentation in human U937 cells assessed as ladder-like pattern at 2 mM after 24 hrs [AID315167, Type: Literature]
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46
[SID103173444]
IC50 56.2Inhibition of alpha-glucosidase using para-nitrophenyl substrate [AID541338, Type: Literature]
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47
[SID103173444]
IC50 62Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type) [AID34797, Type: Literature]
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48
[SID103173444]
IC50 80.41Inhibition of human recombinant MAOB by fluorimetric method [AID409943, Type: Literature]Amine oxidase [flavin-containing] B [gi:113980]
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49
[SID103173444]
IC50 89.9Inhibition kidney aldose reductase 2 by spectrophotometric analysis [AID516863, Type: Literature]
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50
[SID103173444]
IC50 100Inhibition of CK2 in rat liver [AID317243, Type: Literature]
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