4-methylumbelliferone (CID 5280567) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(23)
 
 
Inactive(595)
 
 
Inconclusive(53)
 
 
Unspecified(100)
 
 
Top Targets:
GT1 Gtf like(14)
 
 
p450(10)
 
 
 
 
 
7TM GPCR Srx(10)
 
 
TRP 2(5)
 
 
7TM GPCR Srsx(5)
 
 
BioAssay Types:
Screening(320)
 
 
 
 
Confirmatory(236)
 
 
 
 
 
Literature(175)
 
 
 
 
 
BioActivity Types:
Potency(133)
 
 
 
 
 
IC50(23)
 
 
 
 
Ki(4)
 
 
 
EC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 683    Data Row: 771   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103173444]
Ki 0.56Inhibition of human recombinant CA9 after 6 hrs by stopped flow CO2 hydration assay [AID641825, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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2
[SID103173444]
IC50 1Inhibition of human 17beta-HSD3 expressed in HeLa cells [AID452459, Type: Literature]Testosterone 17-beta-dehydrogenase 3 [gi:1169300]
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3
[SID11112236]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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4
[SID103173444]
Ki 8.1Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay [AID641826, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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5
[SID11112236]
Potency 10qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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6
[SID103173444]
IC50 24.5Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis [AID516862, Type: Literature]Aldose reductase [gi:113596]
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7
[SID47193740]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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8
[SID47193740]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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9
[SID47193740]
 Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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10
[SID47193740]
 Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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11
[SID47193740]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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12
[SID47193740]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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13
[SID11112236]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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14
[SID11112236]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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15
[SID47193740]
 Rml C and D fluorescent artifact dose-response confirmation [AID1696, Type: confirmatory]dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD [Mycobacterium tuberculosis H37Rv] [gi:15610402]
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16
[SID47193740]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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17
[SID47193740]
 Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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18
[SID11112236]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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19
[SID11112236]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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20
[SID11112236]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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21
[SID47193740]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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22
[SID47193740]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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23
[SID47193740]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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24
[SID47193740]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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25
[SID11112236]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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26
[SID11112236]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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27
[SID11112236]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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28
[SID11112236]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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29
[SID47193740]
 Rml C and D inhibition 384-well mixture HTS [AID1532, Type: screening]
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30
[SID103173444]
 Effect on DNA fragmentation in human U937 cells assessed as ladder-like pattern at 2 mM after 24 hrs [AID315167, Type: Literature]
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31
[SID11112236]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
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32
[SID11112236]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_51, Type: Literature]
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33
[SID11112236]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_61, Type: Literature]
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34
[SID103173444]
IC50 56.2Inhibition of alpha-glucosidase using para-nitrophenyl substrate [AID541338, Type: Literature]
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35
[SID103173444]
IC50 62Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type) [AID34797, Type: Literature]
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36
[SID103173444]
IC50 80.41Inhibition of human recombinant MAOB by fluorimetric method [AID409943, Type: Literature]Amine oxidase [flavin-containing] B [gi:113980]
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37
[SID103173444]
IC50 89.9Inhibition kidney aldose reductase 2 by spectrophotometric analysis [AID516863, Type: Literature]
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38
[SID103173444]
IC50 100Inhibition of CK2 in rat liver [AID317243, Type: Literature]
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39
[SID103173444]
Ki 100Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assay [AID641823, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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40
[SID103173444]
Ki 100Inhibition of human full-length cytosolic CA2 after 6 hrs by stopped flow CO2 hydration assay [AID641824, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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41
[SID103173444]
Km 140Activity of Streptomyces antibioticus OleD P67T/S132F/A242V mutant assessed as as rate of glucoside formation using varying compound concentration by enzyme kinetics assay [AID503243, Type: Literature]
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42
[SID103173444]
IC50 153Inhibition sorbitol dehydrogenase by spectrophotometric analysis [AID516864, Type: Literature]
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43
[SID103173444]
IC50 200Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA [AID539405, Type: Literature]
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44
[SID103173444]
Km 300Activity of Streptomyces antibioticus wild-type OleD assessed as as rate of glucoside formation at 10 mM using varying NDP sugar UDP-glucose concentration by enzyme kinetics assay [AID503241, Type: Literature]
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45
[SID103173444]
IC50 2000Growth inhibition of human U937 cells by [3H]thymidine incorporation assay [AID315165, Type: Literature]
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46
[SID103173444]
CC50 2000Cytotoxicity against human U937 cells by trypan blue assay after 48 hrs [AID315164, Type: Literature]
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47
[SID103173444]
EC50 8900Antioxidant activity assessed as DPPH free radical scavenging activity after 10 mins by UV-Vis spectrophotometric analysis [AID630751, Type: Literature]
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48
[SID103173444]
MIC 85100Antibacterial against Bacillus cereus ATCC 11778 after 24 hrs by NCCLS M7-A6 method [AID599325, Type: Literature]
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49
[SID103173444]
 Antimicrobial activity against Staphylococcus aureus ATCC 25923 by twofold broth dilution method [AID568482, Type: Literature]
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50
[SID103173444]
 Antimicrobial activity against methicillin-resistant Staphylococcus aureus N 315 by twofold broth dilution method [AID568483, Type: Literature]
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