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BioActivity Data for Compound Leukotriene B4 (CID 5280492)

BioActivity Outcomes:
Active(16)
 
 
Inactive(127)
 
 
Inconclusive(4)
 
 
Unspecified(2)
 
 
Top Targets:
Tubulin-bindi..(6)
 
 
NR LBD TR(6)
 
 
PLDc mTdp1 2(5)
 
 
HELICc(5)
 
 
GH27(5)
 
 
BioAssay Types:
Confirmatory(125)
 
 
 
 
Literature(12)
 
 
 
 
Screening(8)
 
 
BioAssay Categories:
In vitro(2)
 
 
 
Biochemical(16)
 
 
 
Cell-based(1)
 
 
BioActivity Types:
Potency(107)
 
 
 
Ki(9)
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 77    Data Row: 149   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103256813]
Ki 0.00012Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes [AID101311, Type: confirmatory]
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2
[SID103256813]
Ki 0.00012LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes [AID101312, Type: confirmatory]
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3
[SID103256813]
Ki 0.00012Inhibition of specific binding of [3H]-LTB4 to LTB4 receptor in guinea pig lung membranes [AID101313, Type: confirmatory]
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4
[SID103256813]
Ki 0.00012Binding affinity towards Leukotriene B4 receptor guinea pig lung membrane using [3H]LTB4 as radioligand [AID102297, Type: Literature]
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5
[SID103256813]
Ki 0.00012Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor [AID102301, Type: Literature]
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6
[SID103256813]
IC50 0.00179Compound was tested for inhibitory activity against leukotriene B4 induced neutrophil chemotaxis [AID222481, Type: confirmatory]
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7
[SID103256813]
IC50 0.0019Inhibition of specific binding of [3H]LTB4 to LTB4 receptor in human neutrophils [AID101322, Type: confirmatory]Leukotriene B4 receptor 2 [gi:23821812]
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8
[SID103256813]
IC50 0.0019Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils [AID102466, Type: Literature]
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9
[SID103256813]
Ki 0.0019Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor [AID102647, Type: Literature]
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10
[SID103256813]
Ki 0.0019LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil [AID101435, Type: confirmatory]
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11
[SID103256813]
Ki 0.0019Binding affinity towards human LTB4 receptor measured as inhibition of binding of [3H]LTB4 to isolated human neutrophils [AID102636, Type: Literature]
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12
[SID103256813]
IC50 0.0019In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils [AID101318, Type: confirmatory]
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13
[SID103256813]
IC50 0.0019Inhibition of specific binding of [3H]LTB4 to LTB4 receptor in human neutrophils [AID101322, Type: confirmatory]Leukotriene B4 receptor 1 [gi:3041713]
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14
[SID103256813]
Ki 0.0029Displacement of [3H]LTB4 from LTB4R [AID338156, Type: Literature]
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15
[SID103256813]
IC50 0.032Inhibitory activity against leukotriene B4 receptor [AID102454, Type: confirmatory]Leukotriene B4 receptor 1 [gi:3041713]
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16
[SID103256813]
Inhibition of tube formation in human EAhy926 cells at 10 uM pre-incubated for 12 hrs measured after 24 hrs by phase-contrast microscopy [AID396465, Type: Literature]
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17
[SID103256813]
In vitro Ka value against human serum albumin; N=1 [AID238099, Type: Literature]Serum albumin [gi:113576]
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18
[SID103256813]
Displacement of [3H]LTB4 from LTB4R assessed as specific binding relative to total binding [AID338193, Type: Literature]
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19
[SID26754793]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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20
[SID104046421]
Screening small molecules to find regulators of human embryonic stem cell survival. [AID493140, Type: screening]
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