Leukotriene B4 (CID 5280492) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(15)
 
 
Inactive(108)
 
 
Inconclusive(4)
 
 
Unspecified(4)
 
 
Top Targets:
Tubulin-bindi..(6)
 
 
NR LBD TR(6)
 
 
PLN02808(5)
 
 
HELICc(5)
 
 
Peptidase C1A(4)
 
 
BioAssay Types:
Confirmatory(100)
 
 
 
Literature(10)
 
 
 
 
Screening(6)
 
 
BioActivity Types:
Potency(94)
 
 
 
Ki(9)
 
 
IC50(5)
 
 
Kd(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 73    Data Row: 131   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103256813]
Ki 0.00012Binding affinity towards Leukotriene B4 receptor guinea pig lung membrane using [3H]LTB4 as radioligand [AID102297, Type: Literature]
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2
[SID103256813]
Ki 0.00012Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor [AID102301, Type: Literature]
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3
[SID103256813]
Ki 0.00012Inhibition of specific binding of [3H]-LTB4 to LTB4 receptor in guinea pig lung membranes [AID101313, Type: other]
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4
[SID103256813]
Ki 0.00012LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes [AID101312, Type: other]
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5
[SID103256813]
Ki 0.00012Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes [AID101311, Type: other]
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6
[SID103256813]
IC50 0.00179Compound was tested for inhibitory activity against leukotriene B4 induced neutrophil chemotaxis [AID222481, Type: other]
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7
[SID103256813]
IC50 0.0019Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils [AID102466, Type: Literature]
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8
[SID103256813]
Ki 0.0019Binding affinity towards human LTB4 receptor measured as inhibition of binding of [3H]LTB4 to isolated human neutrophils [AID102636, Type: Literature]
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9
[SID103256813]
Ki 0.0019Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor [AID102647, Type: Literature]
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10
[SID103256813]
IC50 0.0019Inhibition of specific binding of [3H]LTB4 to LTB4 receptor in human neutrophils [AID101322, Type: other]Leukotriene B4 receptor 1 [gi:3041713]
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11
[SID103256813]
IC50 0.0019In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils [AID101318, Type: other]
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12
[SID103256813]
Ki 0.0019LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil [AID101435, Type: other]
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13
[SID103256813]
Ki 0.0029Displacement of [3H]LTB4 from LTB4R [AID338156, Type: other]
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14
[SID103256813]
IC50 0.032Inhibitory activity against leukotriene B4 receptor [AID102454, Type: other]Leukotriene B4 receptor 1 [gi:3041713]
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15
[SID103256813]
 Inhibition of tube formation in human EAhy926 cells at 10 uM pre-incubated for 12 hrs measured after 24 hrs by phase-contrast microscopy [AID396465, Type: Literature]
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16
[SID103256813]
Kd 0.0007GRAC: human BLT1 probe [AID540703, Type: other]Leukotriene B4 receptor 1 [gi:3041713]
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17
[SID103256813]
Kd 0.023GRAC: human BLT2 probe [AID540564, Type: other]Leukotriene B4 receptor 2 [gi:23821812]
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18
[SID103256813]
 In vitro Ka value against human serum albumin; N=1 [AID238099, Type: Literature]Serum albumin [gi:113576]
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19
[SID103256813]
 Displacement of [3H]LTB4 from LTB4R assessed as specific binding relative to total binding [AID338193, Type: other]
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20
[SID26754791]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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21
[SID26754791]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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22
[SID26754791]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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23
[SID26754792]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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24
[SID26754792]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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25
[SID26754792]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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26
[SID26754792]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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27
[SID26754793]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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28
[SID26754793]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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29
[SID26754793]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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30
[SID104046421]
 Screening small molecules to find regulators of human embryonic stem cell survival. [AID493140, Type: screening]
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31
[SID99302212]
 A screen for compounds that inhibit processive DNA synthesis of vaccinia virus [AID493162, Type: other]DNA polymerase [Vaccinia virus] [gi:335756]
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32
[SID26754792]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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33
[SID26754791]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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34
[SID26754791]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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35
[SID26754792]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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36
[SID26754793]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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37
[SID26754792]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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38
[SID26754791]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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39
[SID26754793]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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40
[SID26754791]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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41
[SID26754793]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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42
[SID26754792]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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43
[SID26754792]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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44
[SID26754792]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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45
[SID99302212]
 A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities [AID588519, Type: Literature]Chain A, Poliovirus Polymerase With Gtp [gi:52695378]
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46
[SID99300694]
 A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities [AID588519, Type: Literature]Chain A, Poliovirus Polymerase With Gtp [gi:52695378]
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47
[SID99300694]
 A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtI [AID493033, Type: other]Isochorismate synthase/isochorismate-pyruvate lyase mbtI [gi:81706979]
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48
[SID26754792]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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49
[SID26754791]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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50
[SID26754792]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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