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BioActivity Data for Compound beta Carotene (CID 5280489)

BioActivity Outcomes:
Active(16)
 
 
Inactive(358)
 
 
Inconclusive(30)
 
 
Unspecified(182)
 
 
Top Targets:
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
HCV capsid(5)
 
 
 
7tm 4(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Literature(240)
 
 
 
 
 
Confirmatory(146)
 
 
 
 
 
Screening(133)
 
 
 
 
Summary(15)
 
 
BioAssay Categories:
In vitro(7)
 
 
 
 
In vivo(2)
 
 
Biochemical(121)
 
 
 
 
Toxicity(65)
 
 
 
 
ADME(59)
 
 
 
Cell-based(206)
 
 
 
 
 
Organism-base..(7)
 
 
 
BioActivity Types:
Potency(140)
 
 
 
 
 
IC50(16)
 
 
 
EC50(2)
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 515    Data Row: 586   Total Pages: 30   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103401011]
IC50 0.0127Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells after 48 hrs [AID288764, Type: Literature]
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2
[SID103401011]
Ki 0.34Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells [AID977601, Type: Literature]
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3
[SID103401011]
IC50 0.6166pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells [AID977600, Type: Literature]
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4
[SID103401011]
Ki 2.26Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells [AID977604, Type: Literature]
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5
[SID103401011]
IC50 2.95121pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells [AID977603, Type: Literature]
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6
[SID144205110]
Potency 5.0119High Throughput Screening for Foot and Mouth Disease Virus Antivirals [AID1159524, Type: confirmatory]
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7
[SID103401011]
EC50 6.3Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay [AID323922, Type: Literature]
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8
[SID103401011]
IC50 16.9Antioxidant activity assessed as hydrogen peroxide scavenging activity by peroxyoxalate chemiluminescent method [AID452853, Type: Literature]
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9
[SID47193664]
TR-FRET-based primary biochemical high-throughput screening assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization [AID1899, Type: screening]core protein, partial [Hepatitis C virus] [gi:83779224]
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10
[SID103401011]
Antiradical activity assessed as DPPH radical scavenging activity at 1050 uM by spectrophotometry relative to control [AID378050, Type: Literature]
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11
[SID47193664]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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12
[SID48415624]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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13
[SID48413385]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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14
[SID103401011]
Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/C-5B/KE/poly cells after 72 hrs by luciferase reporter assay [AID323924, Type: Literature]
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15
[SID103401011]
Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/3-5B/KE/poly cells after 72 hrs by luciferase reporter assay [AID323925, Type: Literature]
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16
[SID103401011]
Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 24 hrs by luciferase reporter assay [AID323928, Type: Literature]
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17
[SID103401011]
Inhibitory effect on TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 500 mol ratio/32 pmol TPA relative to TPA [AID287071, Type: Literature]
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18
[SID103401011]
Inhibitory effect on TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 100 mol ratio/32 pmol TPA relative to TPA [AID287072, Type: Literature]
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19
[SID103401011]
Cell viability of Raji cells at 1000 mol ratio/32 pmol TPA relative to TPA [AID287081, Type: Literature]
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20
[SID103401011]
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 molar ratio after 48 hrs relative to TPA [AID332213, Type: Literature]
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