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Calcitriol (CID 5280453) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(161)
 
 
Top Targets:
NR LBD VDR(59)
 
 
NR LBD AR(3)
 
 
LRR RI(3)
 
 
NR LBD ER(2)
 
 
7TM GPCR Srsx(2)
 
 
BioAssay Types:
Literature(119)
 
 
Confirmatory(22)
 
 
Screening(11)
 
 
Summary(4)
 
 
BioActivity Types:
EC50(37)
 
 
IC50(23)
 
 
Potency(20)
 
 
Ki(11)
 
 
Kd(5)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 160    Data Row: 161   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103221863]
IC50 1e-05Cytotoxicity against human HCT116 assessed as decrease in cell count after 120 hrs [AID688523, Type: Literature]
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2
[SID103221863]
EC50 1e-05Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activation measured 24 hrs post infection by luciferase reporter gene assay [AID622098, Type: Literature]Vitamin D3 receptor [gi:137617]
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3
[SID103221863]
EC50 1.06e-05Effect on VDR transcriptional activity in human osteosarcoma cells [AID321740, Type: Literature]Vitamin D3 receptor [gi:137617]
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4
[SID103221863]
Ki 2.5e-05Displacement from vitamin D receptor in chick intestine: 50% displacement [AID216827, Type: confirmatory]Vitamin D3 receptor [gi:3915243]
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5
[SID103221863]
EC50 2.6e-05Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assay [AID760217, Type: Literature]Vitamin D3 receptor [gi:137617]
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6
[SID103221863]
IC50 2.9e-05Inhibition of LPS-induced TNFalpha production in human PBMC after 24 hrs by ELISA [AID414857, Type: Literature]
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7
[SID103221863]
IC50 3e-05Antiproliferative activity against mouse LM05e cells assessed as decrease in cell number after 72 hrs by WST assay [AID652552, Type: Literature]
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8
[SID103221863]
IC50 5e-05Concentration to inhibit T-cell activation in Murine MLR [AID210294, Type: confirmatory]
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9
[SID103221863]
EC50 5e-05Displacement of 1-alpha,25-dihydroxyvitamin from rat recombinant VDR [AID303407, Type: Literature]Vitamin D3 receptor [gi:137618]
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10
[SID103221863]
Ki 5e-05Displacement of [3H]1-alpha,25-(OH)2D3 from rat recombinant full length VDR [AID387114, Type: Literature]Vitamin D3 receptor [gi:137618]
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11
[SID103221863]
EC50 5e-05Displacement of [3H]1,25-(OH)2D3 from bovine thymus vitamin D receptor [AID366868, Type: Literature]Vitamin D3 receptor [gi:161784270]
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12
[SID103221863]
Kd 6.5e-05Binding affinity to VDR receptor [AID217167, Type: Literature]
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13
[SID103221863]
Kd 7e-05Displacement of [3H]1-alpha,25-(OH)2D3 from VDR in pig intestinal mucosa [AID472015, Type: Literature]Vitamin D3 receptor [gi:190411613]
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14
[SID103221863]
EC50 7.1e-05Displacement of [3H]1,25-(OH)2D3 from vitamin D receptor in bovine thymus [AID280114, Type: Literature]Vitamin D3 receptor [gi:161784270]
View
15
[SID103221863]
EC50 0.0001Displacement of [3H]1,25-(OH)2D3 from rat recombinant His-tagged VDR ligand-binding domain expressed in Escherichia coli BL21 [AID326337, Type: Literature]Vitamin D3 receptor [gi:137618]
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16
[SID103221863]
Ki 0.0001Displacement of [3H]1-alpha,25-(OH)2D3 from rat recombinant full length VDR [AID351849, Type: Literature]Vitamin D3 receptor [gi:137618]
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17
[SID103221863]
Ki 0.0001Displacement of [3H]1-alpha,25-(OH)2D3 from rat recombinant full length VDR [AID392905, Type: Literature]Vitamin D3 receptor [gi:137618]
View
18
[SID103221863]
Ki 0.0001Displacement of radiolabeled 1-alpha,25-(OH)2D3 from rat recombinant full length VDR [AID455160, Type: Literature]Vitamin D3 receptor [gi:137618]
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19
[SID103221863]
Ki 0.0001Displacement of radiolabeled 1alpha, 25-(OH)2D3 from recombinant rat VDR [AID619442, Type: Literature]Vitamin D3 receptor [gi:137618]
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20
[SID103221863]
Ki 0.0001Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR [AID547392, Type: Literature]Vitamin D3 receptor [gi:137618]
View