Linoleic Acid (CID 5280450) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(29)
 
 
Inactive(339)
 
 
Inconclusive(30)
 
 
Unspecified(62)
 
 
Top Targets:
NR LBD TR(12)
 
 
NR LBD PPAR(11)
 
 
 
 
 
NR LBD ROR li..(7)
 
 
NR LBD VDR(7)
 
 
 
NR LBD ER(6)
 
 
 
 
BioAssay Types:
Confirmatory(261)
 
 
 
 
Literature(162)
 
 
 
 
 
Screening(15)
 
 
BioActivity Types:
Potency(219)
 
 
 
 
IC50(26)
 
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 299    Data Row: 460   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17388946]
Potency 0.1585qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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2
[SID17388946]
Potency 0.1585qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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3
[SID103167732]
EC50 0.54Agonist activity at GPR40 [AID371570, Type: Literature]
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4
[SID103167732]
EC50 0.54Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay [AID371576, Type: Literature]Free fatty acid receptor 1 [gi:3122157]
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5
[SID103167732]
IC50 1Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP3 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to linoleic acid [AID483948, Type: Literature]Fatty acid-binding protein, heart [gi:119802]
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6
[SID103167732]
IC50 1Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to linoleic acid [AID483950, Type: Literature]Fatty acid-binding protein, adipocyte [gi:119781]
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7
[SID103167732]
IC50 1Allosteric inhibition of soybean LO1 [AID455080, Type: Literature]Seed linoleate 13S-lipoxygenase-1 [gi:126398]
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8
[SID103167732]
EC50 1.8Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay [AID371573, Type: Literature]Free fatty acid receptor 1 [gi:3122157]
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9
[SID17388946]
Potency 8.9125qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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10
[SID17388946]
Potency 8.9125qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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11
[SID17388946]
Potency 8.9125qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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12
[SID103167732]
IC50 11Competitive inhibition of soybean LO1 [AID455078, Type: Literature]Seed linoleate 13S-lipoxygenase-1 [gi:126398]
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13
[SID103167732]
IC50 13Mixed-type inhibition of soybean LO1 [AID455079, Type: Literature]Seed linoleate 13S-lipoxygenase-1 [gi:126398]
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14
[SID103167732]
IC50 13Inhibition of COX1 [AID403341, Type: Literature]
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15
[SID103167732]
IC50 13.6Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins [AID483947, Type: Literature]Fatty acid-binding protein, adipocyte [gi:119781]
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16
[SID17388946]
Potency 17.7828qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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17
[SID17388946]
Potency 17.7828qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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18
[SID103167732]
EC50 20.2Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay [AID323922, Type: Literature]
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19
[SID103167732]
IC50 27Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with factor 7a for 15 mins [AID402797, Type: Literature]
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20
[SID17388946]
Potency 28.1838qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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21
[SID17388946]
Potency 28.1838qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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22
[SID103167732]
IC50 30Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with factor 7a for 90 mins [AID402798, Type: Literature]
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23
[SID103167732]
Km 39Activity of soybean lipooxygenase 1 [AID409935, Type: Literature]
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24
[SID103167732]
IC50 41Inhibition of amidolytic activity of human tissue factor/human factor 7a [AID402795, Type: Literature]Tissue factor [gi:135666]
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25
[SID144204618]
Potency 44.6684qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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26
[SID144204618]
Potency 44.6684qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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27
[SID103167732]
IC50 48Inhibition of aromatase in human placental microsomes by radiometric method [AID376617, Type: Literature]Cytochrome P450 19A1 [gi:117293]
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28
[SID103167732]
 Binding affinity to Vibrio cholerae cholera toxin assessed as apparent isoelectric point at 100 mM by isoelectric focusing analysis (isoelectric point Rvb=6.8) [AID423129, Type: Literature]
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29
[SID103167732]
 Binding affinity to Vibrio cholerae cholera toxin assessed as decrease in fluorescence intensity by fluorescence emission spectroscopy [AID423130, Type: Literature]
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30
[SID103167732]
 Inhibition of intestinal fluid accumulation in rabbit ligated ileal loop model at 3.3 mM injected in presence of cholera toxin after 16 hrs [AID423133, Type: Literature]
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31
[SID103167732]
 Binding affinity to enterotoxigenic Escherichia coli 12566 heat-labile enterotoxin assessed as inhibition of heat-labile enterotoxin binding to ganglioside GM1 receptor [AID423137, Type: Literature]
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32
[SID103167732]
 Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/C-5B/KE/poly cells after 72 hrs by luciferase reporter assay [AID323924, Type: Literature]
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33
[SID103167732]
 Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/3-5B/KE/poly cells after 72 hrs by luciferase reporter assay [AID323925, Type: Literature]
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34
[SID103167732]
 Agonist activity at human GPR40 expressed in CHOK1 cells assessed as effect on calcium flux at 10 uM by fluorescence assay [AID371575, Type: Literature]Free fatty acid receptor 1 [gi:3122157]
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35
[SID103167732]
 Ratio of proximal to distal region oxidation by 1-lipoxygenase isolated from soybean; Ratio of proximal and distal was 97:3 [AID3081, Type: Literature]Seed linoleate 13S-lipoxygenase-1 [gi:126398]
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36
[SID103167732]
LD50 10Cytotoxicity against mouse RAW264.7 cells [AID627981, Type: Literature]
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37
[SID103167732]
IC50 65Displacement of [3H]DPCPX from rat adenosine A1 receptor by liquid scintillation counting [AID380176, Type: Literature]Adenosine receptor A [gi:2827766]
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38
[SID103167732]
IC50 94Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid [AID360927, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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39
[SID103167732]
IC50 100Inhibition of GST-tagged human VHR using pNpp as substrate after 30 mins [AID630399, Type: Literature]Dual specificity protein phosphatase 3 [gi:1718191]
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40
[SID103167732]
IC50 100Inhibition of GST-tagged human VHR using pNpp as substrate after 30 mins [AID630399, Type: Literature]Dual specificity protein phosphatase 3 [gi:1718191]
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41
[SID103167732]
IC50 100Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 mins [AID630402, Type: Literature]Tyrosine-protein phosphatase non-receptor type 7 [gi:20141721]
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42
[SID103167732]
IC50 100Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 mins [AID630402, Type: Literature]Tyrosine-protein phosphatase non-receptor type 7 [gi:20141721]
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43
[SID103167732]
IC50 100Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 mins [AID630402, Type: Literature]Tyrosine-protein phosphatase non-receptor type 7 [gi:20141721]
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44
[SID103167732]
IC50 100Inhibition of GST-tagged human SHP2 N-terminal SH2 domain deficient mutant PTP activity using pNpp as substrate after 30 mins [AID630398, Type: Literature]
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45
[SID103167732]
IC50 170Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid [AID360928, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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46
[SID103167732]
IC50 200Inhibition of amidolytic activity of human recombinant soluble tissue factor (Ala-TF 1 to 219)/human factor 7a [AID402796, Type: Literature]
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47
[SID103167732]
IC50 200Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with tissue factor for 15 mins [AID402799, Type: Literature]
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48
[SID103167732]
IC50 200Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with tissue factor for 90 mins [AID402800, Type: Literature]
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49
[SID103167732]
IC50 200Inhibition of pig pancreatic trypsin after 15 mins [AID402793, Type: Literature]Trypsin [gi:136429]
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50
[SID103167732]
IC50 410Binding affinity to Vibrio cholerae cholera toxin assessed as inhibition of cholera toxin binding to ganglioside GM1 receptor treated 15 mins before receptor addition by ELISA [AID423126, Type: Literature]
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