Bookmark and Share
Apigenin (CID 5280443) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(242)
 
 
Inactive(1208)
 
 
Inconclusive(352)
 
 
Unspecified(282)
 
 
Top Targets:
NR LBD PPAR(32)
 
 
 
 
 
p450(32)
 
 
 
 
7TM GPCR Srx(27)
 
 
 
NR LBD TR(26)
 
 
 
 
NR LBD GR(20)
 
 
 
 
BioAssay Types:
Confirmatory(950)
 
 
 
 
 
Literature(407)
 
 
 
 
 
Screening(383)
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(800)
 
 
 
 
 
IC50(127)
 
 
 
 
 
EC50(16)
 
 
 
 
Ki(15)
 
 
 
 
Kd(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1335    Data Row: 2084   Total Pages: 42   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165116]
IC50 0.025Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
View
2
[SID103165116]
Ki 0.064Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
View
3
[SID103165116]
IC50 0.13Binding affinity towards human estrogen receptor beta (ERbeta) [AID70520, Type: Literature]
View
4
[SID103165116]
Ki 0.39Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
View
5
[SID11113975]
Potency 0.3981qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
6
[SID11113975]
Potency 0.3981qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
7
[SID103165116]
IC50 0.427Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
View
8
[SID103165116]
IC50 0.5Inhibition of COX2 protein expression in mouse RAW264.7 cells [AID403634, Type: Literature]
View
9
[SID103165116]
Kd 0.66Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor [gi:1706709]
View
10
[SID103165116]
Kd 0.66Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor beta [gi:13124234]
View
11
[SID103165116]
IC50 0.7Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
View
12
[SID103165116]
IC50 0.71Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406995, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
View
13
[SID103165116]
Ki 0.74Inhibitory constant against Zea mays CK2alpha [AID435763, Type: Literature]
View
14
[SID103165116]
Ki 0.77In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (using [3H]- flumazenil as radioligand). [AID40670, Type: Literature]
View
15
[SID103165116]
IC50 0.795Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
View
16
[SID103165116]
IC50 0.8Inhibition of CK2 [AID378676, Type: Literature]
View
17
[SID103165116]
IC50 0.8Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) [AID352795, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
View
18
[SID103165116]
IC50 0.9Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Aromatase [gi:117293]
View
19
[SID103165116]
I50 0.92Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
View
20
[SID103165116]
IC50 1Inhibition of aromatase expressed in human H295R cells [AID387614, Type: Literature]
View
21
[SID103165116]
IC50 1.13Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay [AID510244, Type: Literature]
View
22
[SID103165116]
IC50 1.2Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
View
23
[SID103165116]
IC50 1.2Inhibition of wild-type CK2 holoenzyme [AID435640, Type: Literature]
View
24
[SID103165116]
IC50 1.253Binding affinity towards human estrogen receptor alpha(ERalpha) [AID70319, Type: Literature]
View
25
[SID11113975]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
26
[SID103165116]
IC50 1.33Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
View
27
[SID144213201]
Potency-Replicate_1 1.3685qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
28
[SID144213201]
Ratio Potency (uM) 1.36854qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
View
29
[SID103165116]
IC50 1.4Inhibition of glycogen synthase kinase 3 [AID240981, Type: Literature]
View
30
[SID103165116]
IC50 1.45Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay [AID730328, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
31
[SID103165116]
IC50 1.6Inhibition of Cyclin-dependent kinase 5-p25nck5a [AID241232, Type: Literature]
View
32
[SID103165116]
IC50 1.7Inhibition of human MAOA [AID461721, Type: Literature]
View
33
[SID103165116]
IC50 1.7Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin) [AID242481, Type: Literature]Cyclin-dependent kinase 6 [gi:266423]
View
34
[SID144208740]
Potency-Replicate_1 1.7457qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
35
[SID11113975]
Potency 1.7783qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
36
[SID103165116]
Ki 2.4Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay [AID427748, Type: Literature]
View
37
[SID103165116]
IC50 2.8Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB [AID40449, Type: Literature]
View
38
[SID103165116]
GI50 2.81Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay [AID730327, Type: Literature]
View
39
[SID103165116]
IC50 2.9Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assay [AID735784, Type: Literature]Tankyrase-2 [gi:20140805]
View
40
[SID17389511]
Potency 2.9849qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
View
41
[SID103165116]
Ki 3Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes. [AID32357, Type: Literature]
View
42
[SID103165116]
EC50 3Inhibition of SYK in human mast cells assessed as reduction in mast cell degranulation [AID701064, Type: Literature]Lysine--tRNA ligase [gi:20178333]
View
43
[SID103165116]
Ki 3.01995Binding affinity towards benzodiazepine site in GABAA receptor [AID72729, Type: Literature]
View
44
[SID103165116]
IC50 3.1Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [AID578759, Type: Literature]
View
45
[SID103165116]
IC50 3.1Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assay [AID735786, Type: Literature]Tankyrase-1 [gi:226693566]
View
46
[SID11110729]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
47
[SID90341029]
Potency 3.2643qHTS for Activators of Parkin Expression: LOPAC Validation Assay (FLuc Reporter) [AID720573, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
View
48
[SID103165116]
IC50 3.4Inhibitory effect of compound on superoxide anion generation in rat neutrophils stimulated with fMLP/CB [AID180322, Type: Literature]
View
49
[SID11113975]
Potency 3.5481qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
View
50
[SID103165116]
IC50 3.9Hypochlorous acid scavenging activity assessed as inhibition of DHR oxidation [AID289322, Type: Literature]
View