Apigenin (CID 5280443) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(181)
 
 
Inactive(1018)
 
 
Inconclusive(276)
 
 
Unspecified(257)
 
 
Top Targets:
p450(30)
 
 
 
 
 
NR LBD TR(20)
 
 
 
7TM GPCR Srx(17)
 
 
 
HELICc(15)
 
 
PLN02808(15)
 
 
BioAssay Types:
Confirmatory(740)
 
 
 
 
 
Screening(330)
 
 
 
 
Literature(316)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(562)
 
 
 
 
 
IC50(120)
 
 
 
 
 
EC50(15)
 
 
 
 
Ki(15)
 
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1171    Data Row: 1732   Total Pages: 35   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165116]
IC50 0.025Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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2
[SID103165116]
Ki 0.064Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
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3
[SID103165116]
IC50 0.13Binding affinity towards human estrogen receptor beta (ERbeta) [AID70520, Type: Literature]
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4
[SID103165116]
Ki 0.39Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
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5
[SID11113975]
Potency 0.3981qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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6
[SID103165116]
IC50 0.427Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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7
[SID103165116]
IC50 0.5Inhibition of COX2 protein expression in mouse RAW264.7 cells [AID403634, Type: Literature]
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8
[SID103165116]
Kd 0.66Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]
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9
[SID103165116]
IC50 0.7Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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10
[SID103165116]
IC50 0.71Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406995, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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11
[SID103165116]
Ki 0.74Inhibitory constant against Zea mays CK2alpha [AID435763, Type: Literature]
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12
[SID103165116]
Ki 0.77In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (using [3H]- flumazenil as radioligand). [AID40670, Type: other]
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13
[SID103165116]
IC50 0.795Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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14
[SID103165116]
IC50 0.795Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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15
[SID103165116]
IC50 0.795Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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16
[SID103165116]
IC50 0.8Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) [AID352795, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
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17
[SID103165116]
IC50 0.8Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) [AID352795, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
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18
[SID103165116]
IC50 0.8Inhibition of CK2 [AID378676, Type: Literature]
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19
[SID103165116]
IC50 0.9Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Cytochrome P450 19A1 [gi:117293]
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20
[SID103165116]
I50 0.92Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: other]
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21
[SID103165116]
IC50 1Inhibition of aromatase expressed in human H295R cells [AID387614, Type: Literature]
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22
[SID103165116]
IC50 1.13Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay [AID510244, Type: Literature]
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23
[SID103165116]
IC50 1.2Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
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24
[SID103165116]
IC50 1.2Inhibition of wild-type CK2 holoenzyme [AID435640, Type: Literature]
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25
[SID103165116]
IC50 1.253Binding affinity towards human estrogen receptor alpha(ERalpha) [AID70319, Type: Literature]
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26
[SID11113975]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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27
[SID11113975]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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28
[SID11113975]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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29
[SID103165116]
IC50 1.33Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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30
[SID103165116]
IC50 1.4Inhibition of glycogen synthase kinase 3 [AID240981, Type: Literature]
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31
[SID103165116]
IC50 1.6Inhibition of Cyclin-dependent kinase 5-p25nck5a [AID241232, Type: Literature]
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32
[SID103165116]
IC50 1.7Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin) [AID242481, Type: Literature]Cyclin-dependent kinase 6 [gi:266423]
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33
[SID103165116]
IC50 1.7Inhibition of human MAOA [AID461721, Type: Literature]
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34
[SID11113975]
Potency 1.7783qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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35
[SID11113975]
Potency 1.7783qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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36
[SID103165116]
Ki 2.4Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay [AID427748, Type: Literature]
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37
[SID103165116]
IC50 2.8Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB [AID40449, Type: Literature]
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38
[SID17389511]
Potency 2.9849qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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39
[SID103165116]
Ki 3Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes. [AID32357, Type: Literature]
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40
[SID103165116]
Ki 3.01995Binding affinity towards benzodiazepine site in GABAA receptor [AID72729, Type: Literature]
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41
[SID103165116]
IC50 3.1Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [AID578759, Type: Literature]
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42
[SID11110729]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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43
[SID11110729]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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44
[SID11110729]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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45
[SID103165116]
IC50 3.4Inhibitory effect of compound on superoxide anion generation in rat neutrophils stimulated with fMLP/CB [AID180322, Type: Literature]
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46
[SID11113975]
Potency 3.5481qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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47
[SID11113975]
Potency 3.5481qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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48
[SID11113975]
Potency 3.5481qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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49
[SID103165116]
IC50 3.9Hypochlorous acid scavenging activity assessed as inhibition of DHR oxidation [AID289322, Type: Literature]
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50
[SID26752116]
Potency 3.9811qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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