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Apigenin (CID 5280443) - Compound BioActivity Data
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BioActivity Outcomes:
Active(272)
 
 
Inactive(1227)
 
 
Inconclusive(344)
 
 
Unspecified(306)
 
 
Top Targets:
7tm 4(41)
 
 
 
 
p450(32)
 
 
 
 
NR LBD PPAR(32)
 
 
 
 
 
NR LBD TR(26)
 
 
 
 
NR LBD ER(21)
 
 
 
 
 
BioAssay Types:
Confirmatory(958)
 
 
 
 
 
Literature(455)
 
 
 
 
 
Screening(386)
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(803)
 
 
 
 
 
IC50(143)
 
 
 
 
 
Ki(20)
 
 
 
 
EC50(16)
 
 
 
 
Kd(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1387    Data Row: 2149   Total Pages: 108   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165116]
IC50 0.012Inhibition of AChE (unknown origin) [AID1115338, Type: confirmatory]Acetylcholinesterase [gi:113037]
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2
[SID103165116]
IC50 0.025Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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3
[SID103165116]
Ki 0.064Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
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4
[SID103165116]
IC50 0.13Binding affinity towards human estrogen receptor beta (ERbeta) [AID70520, Type: Literature]
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5
[SID103165116]
Ki 0.39Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
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6
[SID11113975]
Potency 0.3981qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID11113975]
Potency 0.3981qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID103165116]
IC50 0.427Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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9
[SID170484815]
Kd 0.49Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Wild Type Ttr Binding Apigenin (Ttrwt:api) [gi:422919333]
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10
[SID170484815]
Kd 0.49Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Wild Type Ttr Binding Apigenin (Ttrwt:api) [gi:422919333]
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11
[SID103165116]
IC50 0.5Inhibition of COX2 protein expression in mouse RAW264.7 cells [AID403634, Type: Literature]
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12
[SID103165116]
Kd 0.66Displacement of [3H]-estradiol (E2) from sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor [gi:1706709]
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13
[SID103165116]
Kd 0.66Displacement of [3H]-estradiol (E2) from sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor beta [gi:13124234]
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14
[SID103165116]
IC50 0.7Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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15
[SID103165116]
IC50 0.71Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406995, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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16
[SID103165116]
Ki 0.74Inhibitory constant against Zea mays CK2alpha [AID435763, Type: Literature]
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17
[SID103165116]
Ki 0.77In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (using [3H]- flumazenil as radioligand). [AID40670, Type: Literature]
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18
[SID103165116]
IC50 0.795Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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19
[SID103165116]
IC50 0.8Inhibition of CK2 (unknown origin) [AID779050, Type: Literature]
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20
[SID103165116]
IC50 0.8Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) [AID352795, Type: Literature]Casein kinase II subunit alpha [gi:55977123]
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