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Dinoprost (CID 5280363) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(192)
 
 
Inconclusive(20)
 
 
Unspecified(69)
 
 
Top Targets:
MFS(13)
 
 
KAZAL SLC21(11)
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD TR(7)
 
 
BioAssay Types:
Literature(129)
 
 
 
 
 
Confirmatory(122)
 
 
 
 
Summary(15)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(129)
 
 
 
 
IC50(21)
 
 
 
EC50(8)
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 225    Data Row: 307   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103214323]
IC50 0.0025Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells [AID160700, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172442]
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2
[SID103214323]
IC50 0.003In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand [AID223522, Type: Literature]
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3
[SID103214323]
EC50 0.0067Concentration giving half-maximal contraction of the cat iris sphincter muscle was determined in vitro [AID47784, Type: Literature]
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4
[SID103214323]
IC50 0.007Affinity for human Prostanoid FP receptor expressed in COS-7 cells [AID161196, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172442]
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5
[SID103214323]
EC50 0.023Evaluated for its concentration at which 50% of maximal stimulation of phosphoinositide turnover was observed [AID209329, Type: Literature]
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6
[SID103214323]
EC50 0.0245Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells [AID246471, Type: Literature]
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7
[SID103214323]
EC50 0.0245Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting [AID347678, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172443]
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8
[SID103214323]
IC50 0.043Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC) [AID160703, Type: Literature]
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9
[SID103214323]
EC50 0.079Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%) [AID160696, Type: Literature]
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10
[SID103214323]
IC50 0.11In vitro binding at EP3 human prostaglandin receptor using [3H]PGE-2 as radioligand [AID161057, Type: Literature]
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11
[SID103214323]
Ki 0.119Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum [AID161200, Type: Literature]
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12
[SID103214323]
Ki 0.129Binding affinity for Prostanoid FP receptor of bovine corpus luteum [AID238750, Type: Literature]
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13
[SID103214323]
Ki 0.13Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane [AID347677, Type: Literature]Prostaglandin F2-alpha receptor [gi:585664]
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14
[SID103214323]
IC50 0.14Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM) [AID160702, Type: Literature]
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15
[SID103214323]
IC50 0.22In vitro binding at EP1 human prostaglandin receptor using [3H]PGE-2 as radioligand [AID160915, Type: Literature]
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16
[SID103214323]
IC50 0.322Affinity for Prostanoid EP3 receptor expressed in CHO cell line [AID161055, Type: Literature]Prostaglandin E2 receptor EP3 subtype [gi:1172071]
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17
[SID103214323]
IC50 0.38Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. [AID160913, Type: Literature]Prostaglandin E2 receptor EP1 subtype [gi:83287886]
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18
[SID103214323]
EC50 0.6Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%) [AID160545, Type: Literature]
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19
[SID103214323]
EC50 1.4Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=95%) [AID212941, Type: Literature]
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20
[SID103214323]
EC50 2.3Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone=50%) [AID160552, Type: Literature]
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21
[SID103214323]
IC50 4.2In vitro binding at EP4 human prostaglandin receptor using [3H]PGE-2 as radioligand [AID161071, Type: Literature]
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22
[SID103214323]
IC50 4.2Affinity for Prostanoid EP4 receptor expressed in CHO cells [AID161070, Type: Literature]Prostaglandin E2 receptor EP4 subtype [gi:548476]
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23
[SID103214323]
IC50 4.5In vitro binding at DP human prostaglandin receptor using [3H]- PGD-2 as radioligand [AID160909, Type: Literature]
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24
[SID103214323]
IC50 4.5Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells [AID160529, Type: Literature]Prostaglandin D2 receptor [gi:2495009]
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25
[SID144205330]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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26
[SID48415906]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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27
[SID103214323]
IC50 1e-06In vitro binding at TP human prostaglandin receptor using [3H]SQ-29,548 as radioligand [AID210159, Type: Literature]
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28
[SID103214323]
Ki 0.023TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells [AID679658, Type: other]Solute carrier organic anion transporter family member 2A1 [gi:218511799]
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29
[SID103214323]
Ki 0.045TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells [AID679943, Type: other]Solute carrier organic anion transporter family member 2A1 [gi:357529156]
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30
[SID103214323]
Km 0.104TP_TRANSPORTER: uptake in PGT-expressing HeLa cells [AID681576, Type: other]Solute carrier organic anion transporter family member 2A1 [gi:357529156]
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31
[SID103214323]
Ki 0.104TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells [AID679648, Type: other]Solute carrier organic anion transporter family member 2A1 [gi:27734558]
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32
[SID103214323]
IC50 0.287TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes [AID679647, Type: other]Solute carrier organic anion transporter family member 2B1 [gi:27734548]
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33
[SID103214323]
Km 0.334TP_TRANSPORTER: uptake in OCT2-expressing S2 cells [AID682098, Type: other]Solute carrier family 22 member 2 [gi:313104182]
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34
[SID103214323]
Km 0.414TP_TRANSPORTER: uptake in OAT2-S2 cells [AID679359, Type: other]Solute carrier family 22 member 7 [gi:81871841]
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35
[SID103214323]
Km 0.425TP_TRANSPORTER: uptake in OAT2-expressing S2 cells [AID679510, Type: other]Solute carrier family 22 member 7 [gi:74753520]
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36
[SID103214323]
Km 0.477TP_TRANSPORTER: uptake in OCT1-expressing S2 cells [AID680361, Type: other]Solute carrier family 22 member 1 [gi:313104181]
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37
[SID103214323]
Km 0.575TP_TRANSPORTER: uptake in OAT1-expressing S2 cells [AID679829, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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38
[SID103214323]
Km 0.692TP_TRANSPORTER: uptake in OAT4-expressing S2 cells [AID679645, Type: other]Solute carrier family 22 member 11 [gi:74734337]
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39
[SID103214323]
Km 1.092TP_TRANSPORTER: uptake in OAT3-expressing S2 cells [AID679674, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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40
[SID103214323]
IC50 10Affinity for Prostanoid EP2 receptor expressed in CHO cells [AID161039, Type: Literature]Prostaglandin E2 receptor EP2 subtype [gi:38258920]
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41
[SID103214323]
IC50 10Affinity for Prostaglandin I2 receptor expressed in CHO cells [AID160747, Type: Literature]Prostacyclin receptor [gi:1172500]
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42
[SID103214323]
IC50 10Affinity for Prostanoid TP receptor expressed in CHO cells [AID161214, Type: Literature]Thromboxane A2 receptor [gi:229463010]
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43
[SID103214323]
IC50 100In vitro binding at prostanoid IP receptor using [3H]iloprost as radioligand [AID161205, Type: Literature]
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44
[SID103214323]
IC50 100In vitro binding at EP2 human prostaglandin receptor using [3H]PGE-2 as radioligand [AID161041, Type: Literature]
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45
[SID103214323]
IC50 700In vitro antiproliferative activity was measured on human leukemia K562 cells [AID94806, Type: other]
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46
[SID103214323]
Plasma hydrolysis following 2 hr incubation with monkey plasma [AID126987, Type: Literature]
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47
[SID103214323]
Plasma hydrolysis following 20 hr incubation with monkey plasma [AID127108, Type: Literature]
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48
[SID103214323]
Compound was evaluated for diarrheal effect in mice (po administration) [AID129964, Type: Literature]
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49
[SID29216066]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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50
[SID103214323]
Compound was evaluated for gerbil colon contraction relative to PGF2-alpha [AID75111, Type: Literature]
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