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Dinoprost (CID 5280363) - Compound BioActivity Data
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BioActivity Outcomes:
Active(27)
 
 
Inactive(193)
 
 
Inconclusive(20)
 
 
Unspecified(68)
 
 
Top Targets:
MFS(13)
 
 
KAZAL SLC21(11)
 
 
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
NR LBD TR(7)
 
 
BioAssay Types:
Literature(155)
 
 
 
 
 
Confirmatory(124)
 
 
 
 
 
Summary(15)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(130)
 
 
 
 
IC50(21)
 
 
 
EC50(9)
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 226    Data Row: 308   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103214323]
IC50 0.0025Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells [AID160700, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172442]
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2
[SID103214323]
IC50 0.003In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand [AID223522, Type: Literature]
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3
[SID103214323]
EC50 0.0067Concentration giving half-maximal contraction of the cat iris sphincter muscle was determined in vitro [AID47784, Type: Literature]
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4
[SID103214323]
IC50 0.007Affinity for human Prostanoid FP receptor expressed in COS-7 cells [AID161196, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172442]
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5
[SID103214323]
EC50 0.01259Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR [AID726602, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172443]
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6
[SID103214323]
EC50 0.023Evaluated for its concentration at which 50% of maximal stimulation of phosphoinositide turnover was observed [AID209329, Type: Literature]
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7
[SID103214323]
EC50 0.0245Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells [AID246471, Type: Literature]
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8
[SID103214323]
EC50 0.0245Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting [AID347678, Type: Literature]Prostaglandin F2-alpha receptor [gi:1172443]
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9
[SID103214323]
IC50 0.043Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC) [AID160703, Type: Literature]
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10
[SID103214323]
EC50 0.079Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%) [AID160696, Type: Literature]
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11
[SID103214323]
IC50 0.11In vitro binding at EP3 human prostaglandin receptor using [3H]PGE-2 as radioligand [AID161057, Type: Literature]
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12
[SID103214323]
Ki 0.119Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum [AID161200, Type: Literature]
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13
[SID103214323]
Ki 0.129Binding affinity for Prostanoid FP receptor of bovine corpus luteum [AID238750, Type: Literature]
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14
[SID103214323]
Ki 0.13Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane [AID347677, Type: Literature]Prostaglandin F2-alpha receptor [gi:585664]
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15
[SID103214323]
IC50 0.14Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM) [AID160702, Type: Literature]
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16
[SID103214323]
IC50 0.22In vitro binding at EP1 human prostaglandin receptor using [3H]PGE-2 as radioligand [AID160915, Type: Literature]
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17
[SID103214323]
IC50 0.322Affinity for Prostanoid EP3 receptor expressed in CHO cell line [AID161055, Type: Literature]Prostaglandin E2 receptor EP3 subtype [gi:1172071]
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18
[SID103214323]
IC50 0.38Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. [AID160913, Type: Literature]Prostaglandin E2 receptor EP1 subtype [gi:83287886]
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19
[SID103214323]
EC50 0.6Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%) [AID160545, Type: Literature]
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20
[SID103214323]
EC50 1.4Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=95%) [AID212941, Type: Literature]
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