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Bilirubin (CID 5280352) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(54)
 
 
Inconclusive(19)
 
 
Unspecified(22)
 
 
Top Targets:
KAZAL SLC21(8)
 
 
GT1 Gtf like(7)
 
 
PLDc mTdp1 2(3)
 
 
 
globin(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Confirmatory(68)
 
 
 
 
Literature(14)
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(66)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 98    Data Row: 103   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26749657]
Potency 10qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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2
[SID26749657]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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3
[SID26749657]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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4
[SID26749657]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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5
[SID10319019]
Compound Screen Assay, Human DHRS6 [AID510, Type: screening]unnamed protein product [Homo sapiens] [gi:14598968]
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6
[SID10319019]
Compound Screen Assay, Human PECR [AID392, Type: screening]peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] [gi:19923817]
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7
[SID10319019]
Compound Screen Assay, Human BLVRA [AID516, Type: screening]biliverdin reductase A precursor [Homo sapiens] [gi:33589854]
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8
[SID10319019]
Compound Screen Assay, Human HSD11B1 [AID398, Type: other]corticosteroid 11-beta-dehydrogenase isozyme 1 [Homo sapiens] [gi:5031765]
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9
[SID103619919]
Km 0.0076TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID680553, Type: other]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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10
[SID103619919]
Km 0.0391TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID680209, Type: other]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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11
[SID103619919]
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 10 uM) by Bilirubin at a concentration of 100 u M in Xenopus laevis oocytes [AID680382, Type: other]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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12
[SID103619919]
Specific activity of expressed human recombinant UGT1A9 [AID624612, Type: Literature]UDP-glucuronosyltransferase 1-9 [gi:29839451]
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13
[SID103619919]
Specific activity of expressed human recombinant UGT1A6 [AID624609, Type: Literature]UDP-glucuronosyltransferase 1-6 [gi:29840832]
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14
[SID103619919]
Substrates of transporters of clinical importance in the absorption and dispostion of drugs, OATP1B1 [AID588962, Type: Literature]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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15
[SID103619919]
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 10 uM) by Bilirubin at a concentration of 100 u M in Xenopus laevis oocytes [AID680734, Type: other]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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16
[SID103619919]
Km TP_TRANSPORTER: uptake in OATP-C-expressing HEK293 cells [AID681365, Type: other]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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17
[SID103619919]
Specific activity of expressed human recombinant UGT2B17 [AID624617, Type: Literature]UDP-glucuronosyltransferase 2B17 [gi:6136104]
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18
[SID103619919]
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 10 uM) by Bilirubin at a concentration of 100 u M in Xenopus laevis oocytes [AID680019, Type: other]Solute carrier organic anion transporter family member 1A2 [gi:1171882]
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19
[SID103619919]
TP_TRANSPORTER: inhibition of BSP uptake (BSP: 1 uM, Bilirubin: 10 uM) in Xenopus laevis oocytes [AID680645, Type: other]Solute carrier organic anion transporter family member 1A1 [gi:1171883]
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20
[SID103619919]
Apparent permeability across human Caco-2 cells [AID381952, Type: Literature]
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21
[SID103619919]
Apparent permeability across human Caco-2 cells in presence of BSA in basolateral chamber [AID381953, Type: Literature]
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22
[SID103619919]
Metabolic stability in presence of BSA [AID381955, Type: Literature]
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23
[SID103619919]
Toxicity against rat erythrocytes assessed as induction of hemolysis at >= 1000 uM [AID381956, Type: Literature]
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24
[SID103619919]
Toxicity against rat erythrocytes assessed as decrease in hemolysis in presence of BSA [AID381957, Type: Literature]
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25
[SID103619919]
Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset [AID588208, Type: Literature]
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26
[SID103619919]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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27
[SID103619919]
Specific activity of expressed human recombinant UGT2B7 [AID624619, Type: Literature]UDP-glucuronosyltransferase 2B7 [gi:136727]
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28
[SID103619919]
Substrate of human UDP-glucuronosyltransferase UGT1A1 [AID589068, Type: other]UDP-glucuronosyltransferase 1-1 [gi:136729]
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29
[SID103619919]
Specific activity of expressed human recombinant UGT1A1 [AID624606, Type: Literature]UDP-glucuronosyltransferase 1-1 [gi:136729]
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30
[SID103619919]
Specific activity of expressed human recombinant UGT1A4 [AID624608, Type: Literature]UDP-glucuronosyltransferase 1-4 [gi:136731]
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31
[SID26749657]
Potency 10qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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32
[SID26749657]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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33
[SID26749657]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]PINK1 [Homo sapiens] [gi:37183032]
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34
[SID26749657]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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35
[SID26749657]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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36
[SID26749657]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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37
[SID26749657]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID11537670]
NMR Based Screening Assay for Novel Chemotypes against influenza A virus [AID1549, Type: other]M2 [Influenza A virus (A/Taiwan/4845/1999(H1N1))] [gi:89033149]
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39
[SID26749657]
Potency qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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40
[SID26612105]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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41
[SID26612105]
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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42
[SID26749657]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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43
[SID26749657]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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44
[SID26749657]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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45
[SID26749657]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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46
[SID26749657]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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47
[SID26749657]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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48
[SID11537670]
NMR Based Screening Assay for FKBP12 [AID608, Type: other]peptidyl-prolyl cis-trans isomerase FKBP1A isoform a [Homo sapiens] [gi:17149836]
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49
[SID11537670]
NMR Based Screening Assay for the substrate binding domain of the chaperone DnaK [AID1033, Type: screening]DnaK protein homolog [Escherichia coli] [gi:216546]
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50
[SID26749657]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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