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Quercetin (CID 5280343) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(545)
 
 
Inactive(662)
 
 
Inconclusive(238)
 
 
Unspecified(622)
 
 
Top Targets:
p450(28)
 
 
 
 
 
NR LBD TR(20)
 
 
 
 
NR LBD PPAR(19)
 
 
 
 
 
NR LBD ER(18)
 
 
 
 
 
Tubulin-bindi..(18)
 
 
 
 
BioAssay Types:
Literature(1047)
 
 
 
 
 
Confirmatory(756)
 
 
 
 
 
Screening(63)
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(636)
 
 
 
 
 
IC50(295)
 
 
 
 
 
Ki(38)
 
 
 
 
 
EC50(34)
 
 
 
Kd(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1590    Data Row: 2067   Total Pages: 42   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167027]
Ki 0.0078Binding affinity to dopamine D4 receptor [AID478694, Type: Literature]
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2
[SID103167027]
IC50 0.01Inhibition of bovine MAO-A by fluorimetric method [AID377654, Type: Literature]Amine oxidase [flavin-containing] A [gi:124028637]
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3
[SID103167027]
IC50 0.012Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Aromatase [gi:117293]
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4
[SID103167027]
IC50 0.0148Inhibition of cataracted human eye lens aldose reductase [AID388742, Type: Literature]Aldose reductase [gi:113596]
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5
[SID103167027]
Ki 0.022Inhibition of Plasmodium falciparum ENR in presence of triclosan [AID277587, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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6
[SID103167027]
Ki 0.023Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598342, Type: Literature]
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7
[SID103167027]
Kd 0.025Binding affinity to nonphosphorylated PIM1 [AID257082, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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8
[SID103167027]
IC50 0.043Inhibitory activity against PIM1 [AID257081, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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9
[SID103167027]
Ki 0.0453Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method [AID461575, Type: Literature]5'-nucleotidase [gi:112826]
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10
[SID103167027]
IC50 0.06Antioxidant activity assessed as scavenging of glucose oxidase-generated H2O2 and hydroxyl radicals by chemiluminescence assay [AID710235, Type: Literature]
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11
[SID103167027]
IC50 0.077Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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12
[SID11111705]
Potency 0.1259qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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13
[SID11111705]
Potency 0.1259qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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14
[SID103167027]
IC50 0.14Inhibition of Escherichia coli DNA gyrase assessed as inhibition of pBR322 supercoiling by densitometry [AID603461, Type: Literature]
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15
[SID103167027]
IC50 0.14Inhibition of Escherichia coli DNA gyraseB assessed as inhibition of pBR322 supercoiling by densitometry [AID501421, Type: Literature]
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16
[SID103167027]
I50 0.145Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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17
[SID11111706]
Potency 0.1585qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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18
[SID11111706]
Potency 0.1585qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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19
[SID103167027]
ID50 0.17Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: Literature]
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20
[SID50104737]
Potency 0.1995qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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21
[SID124881262]
Potency 0.1995qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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22
[SID124881266]
Potency 0.1995qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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23
[SID103167027]
ID50 0.2Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: Literature]
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24
[SID103167027]
IC50 0.2In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined [AID6820, Type: Literature]
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25
[SID103167027]
I50 0.205Inhibition of rat liver mitochondrial ATPase assessed per mg of protein [AID338025, Type: Literature]
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26
[SID103167027]
IC50 0.24Inhibition of beta amyloid (1 to 40) fibril formation by thioflavin T staining-based binding assay [AID456188, Type: Literature]
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27
[SID11113933]
Potency 0.2512qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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28
[SID11113933]
Potency 0.2512qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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29
[SID103167027]
IC50 0.26Peroxynitrite scavenging activity assessed as inhibition of DHR oxidation [AID289337, Type: Literature]
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30
[SID124881267]
Potency 0.2818qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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31
[SID103167027]
IC50 0.3In vitro inhibitory activity against RBL-1 5-LO [AID6809, Type: Literature]
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32
[SID103167027]
IC50 0.3In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells [AID7096, Type: Literature]
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33
[SID103167027]
IC50 0.4Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation) [AID7079, Type: Literature]
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34
[SID103167027]
IC50 0.43Inhibition of 15LOX in rabbit reticulocytes by EIA assay [AID286229, Type: Literature]Arachidonate 15-lipoxygenase [gi:126397]
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35
[SID103167027]
IC50 0.44Peroxynitrite scavenging activity assessed as inhibition of DHR oxidation in presence of NaHCo3 [AID289341, Type: Literature]
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36
[SID103167027]
IC50 0.44Inhibition of 12-hLO [AID309798, Type: Literature]
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37
[SID124881264]
Potency 0.4467qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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38
[SID103167027]
IC50 0.45Inhibition of CDK1 [AID511076, Type: Literature]
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39
[SID103167027]
Ki 0.473Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate [AID277586, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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40
[SID103167027]
IC50 0.5Antioxidant activity assessed as radical scavenging activity in FMLP-stimulated human PMNC by chemiluminescence assay [AID357035, Type: Literature]
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41
[SID103167027]
IC50 0.5In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay) [AID6855, Type: Literature]
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42
[SID103167027]
IC50 0.55Inhibition of CK2 [AID378676, Type: Literature]
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43
[SID103167027]
IC50 0.55Inhibition of recombinant human CK2 activity assessed as [gamma-32P]ATP incorporation into substrate peptide after 20 mins in presence of 50 uM ATP [AID587344, Type: Literature]
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44
[SID50104737]
Potency 0.5623qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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45
[SID103167027]
IC50 0.59Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay [AID730328, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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46
[SID103167027]
IC50 0.61Antioxidant activity assessed as scavenging of morpholino sydononimine based nitric oxide release by chemiluminescence assay [AID710231, Type: Literature]
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47
[SID103167027]
Ki 0.66Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin [AID598341, Type: Literature]
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48
[SID103167027]
IC50 0.68Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay [AID510244, Type: Literature]
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49
[SID103167027]
I50 0.715Inhibition of beef heart mitochondrial succinoxidase assessed per mg of protein [AID338028, Type: Literature]
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50
[SID103167027]
IC50 0.72Inhibition of beta amyloid (1 to 42) fibril formation by thioflavin T staining-based binding assay [AID456189, Type: Literature]
View