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desmethoxyyangonin (CID 5273621) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(205)
 
 
Inconclusive(33)
 
 
Unspecified(47)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(7)
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(212)
 
 
 
 
Literature(49)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(194)
 
 
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 282    Data Row: 294   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207494]
Potency-Replicate_1 2.518qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID17389067]
Potency 7.0795qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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3
[SID17389067]
Potency-Replicate_1 7.9433qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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4
[SID17389067]
Potency 8.9125qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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5
[SID144207494]
ATAD5 Potency (uM) 10.4167qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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6
[SID103556221]
IC50 13Antiprotozoal activity against erythrocytic stages chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation pre-incubated for 48 hrs prior [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting [AID644368, Type: Literature]
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7
[SID17389067]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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8
[SID17389067]
Potency 44.6684qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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9
[SID144207494]
Potency-Replicate_1 70.968qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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10
[SID103556221]
IC50 64Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes infected in rat L6 myoblasts after 96 hrs by CPRG/Nonidet-based spectrophotometry [AID644366, Type: Literature]
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11
[SID103556221]
ED50 100Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay [AID358852, Type: Literature]
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12
[SID103556221]
ED50 100Antiproliferative activity against human HT1080 cells by MTT assay [AID358853, Type: Literature]
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13
[SID103556221]
IC50 120Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay [AID644365, Type: Literature]
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14
[SID103556221]
IC50 160Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay [AID644369, Type: Literature]
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15
[SID103556221]
IC50 190Antiprotozoal activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by alamar blue assay [AID644367, Type: Literature]
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16
[SID103556221]
Cytotoxicity against human PANC1 cells assessed as cell viability [AID311568, Type: Literature]
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17
[SID103556221]
Selectivity index, ratio of IC50 for erythrocytic stages chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 to IC50 for rat L6 myoblasts [AID644370, Type: Literature]
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18
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of collagen-induced platelet aggregation at 100 ug/mL relative to control [AID399387, Type: Literature]
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19
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of ADP-induced platelet aggregation at 100 ug/mL relative to control [AID399388, Type: Literature]
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20
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 ug/mL relative to control [AID399389, Type: Literature]
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