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desmethoxyyangonin (CID 5273621) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(199)
 
 
Inconclusive(36)
 
 
Unspecified(23)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(7)
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(212)
 
 
 
 
Literature(24)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(193)
 
 
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 258    Data Row: 269   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207494]
Potency-Replicate_1 2.518qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID17389067]
Potency 7.0795qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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3
[SID17389067]
Potency-Replicate_1 7.9433qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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4
[SID17389067]
Potency 8.9125qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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5
[SID144207494]
ATAD5 Potency (uM) 10.4167qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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6
[SID103556221]
IC50 13Antiprotozoal activity against erythrocytic stages chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation pre-incubated for 48 hrs prior [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting [AID644368, Type: Literature]
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7
[SID17389067]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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8
[SID17389067]
Potency 44.6684qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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9
[SID144207494]
Potency-Replicate_1 50.2415qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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10
[SID144207494]
Potency-Replicate_1 63.2503qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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11
[SID144207494]
Potency-Replicate_1 70.968qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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12
[SID103556221]
IC50 64Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes infected in rat L6 myoblasts after 96 hrs by CPRG/Nonidet-based spectrophotometry [AID644366, Type: Literature]
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13
[SID103556221]
ED50 100Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay [AID358852, Type: Literature]
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14
[SID103556221]
ED50 100Antiproliferative activity against human HT1080 cells by MTT assay [AID358853, Type: Literature]
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15
[SID103556221]
IC50 120Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay [AID644365, Type: Literature]
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16
[SID103556221]
IC50 160Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay [AID644369, Type: Literature]
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17
[SID103556221]
IC50 190Antiprotozoal activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by alamar blue assay [AID644367, Type: Literature]
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18
[SID103556221]
MIC 440Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 to 14 days by twofold serial broth dilution method [AID644364, Type: Literature]
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19
[SID103556221]
Cytotoxicity against human PANC1 cells assessed as cell viability [AID311568, Type: Literature]
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20
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of collagen-induced platelet aggregation at 100 ug/mL relative to control [AID399387, Type: Literature]
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21
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of ADP-induced platelet aggregation at 100 ug/mL relative to control [AID399388, Type: Literature]
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22
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 ug/mL relative to control [AID399389, Type: Literature]
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23
[SID103556221]
Antiplatelet activity in human whole blood assessed as inhibition of ristocetin-induced platelet aggregation at 100 ug/mL relative to control [AID399390, Type: Literature]
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24
[SID103556221]
Inhibition of TNF-alpha-induced NF-kappaB expressed in human A549 cells treated 1 hr after TNFalpha challenge measured after 6 hrs by luciferase reporter gene assay [AID447711, Type: Literature]
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25
[SID103556221]
Hepatotoxicity against mouse Hepa-1c1c7 cells after 48 hrs by celltiter blue assay [AID447716, Type: Literature]
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26
[SID103556221]
Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 at 39 uM after 24 hrs by luciferase assay [AID449984, Type: Literature]
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27
[SID103556221]
Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 at 43.9 uM after 24 hrs by luciferase assay [AID449985, Type: Literature]
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28
[SID103556221]
Selectivity index, ratio of IC50 for erythrocytic stages chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 to IC50 for rat L6 myoblasts [AID644370, Type: Literature]
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29
[SID17389067]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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30
[SID103556221]
Antitubercular activity against Mycobacterium tuberculosis assessed as growth inhibition [AID732687, Type: Literature]
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31
[SID103556221]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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32
[SID103556221]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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33
[SID103556221]
Inhibition of PA endonuclease at 10 uM [AID666150, Type: Literature]Polymerase acidic protein [gi:158931133]
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34
[SID103556221]
Inhibition of PA endonuclease at 1 uM [AID666151, Type: Literature]Polymerase acidic protein [gi:158931133]
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35
[SID144207494]
Potency-Replicate_1 0.5024qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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36
[SID17389067]
Potency 1.496qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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37
[SID144207494]
Potency-Replicate_1 2.8253qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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38
[SID17389067]
Potency 15.8489qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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39
[SID144207494]
Potency-Replicate_1 16.0203qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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40
[SID144207494]
Potency-Replicate_1 35.8649qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
41
[SID144207494]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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42
[SID144207494]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
43
[SID17389067]
Potency qHTS assay for small molecule antagonists of retinoid X receptor alpha signaling [AID588546, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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44
[SID144207494]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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45
[SID144207494]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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46
[SID144207494]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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47
[SID144207494]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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48
[SID144207494]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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49
[SID144207494]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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50
[SID17389067]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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