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malic acid (CID 525) - Compound BioActivity Data
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BioActivity Outcomes:
Inactive(1044)
 
 
Inconclusive(16)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
NR LBD PPAR(20)
 
 
 
NR LBD ER(17)
 
 
alkPPc(16)
 
 
BioAssay Types:
Screening(586)
 
 
 
 
Confirmatory(376)
 
 
 
 
Summary(48)
 
 
 
Literature(24)
 
 
 
BioActivity Types:
Potency(331)
 
 
 
 
IC50(48)
 
 
 
EC50(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 895    Data Row: 1066   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160687873]
IC50 1000Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as inhibition of 3-methylthymidine conversion to thymidine after 1 hr by liquid chromatographic analysis [AID734755, Type: Literature]Alpha-ketoglutarate-dependent dioxygenase FTO [gi:148841515]
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2
[SID160687873]
Nematotoxic activity against freshly hatched Meloidogyne incognita J2 (root-knot nematode) isolated from tomato roots assessed as induction of nematode paralysis measured 24 hr after immersion in compound test solutions [AID1083149, Type: Literature]
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3
[SID4243530]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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4
[SID4243530]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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5
[SID4243530]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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6
[SID4243530]
Allosteric Antagonists for the VLA-4 Integrin [AID529, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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7
[SID4243530]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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8
[SID4243530]
Potency 39.8107qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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9
[SID4243530]
Potency 158.489qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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10
[SID4243530]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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11
[SID4243530]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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12
[SID4243530]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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13
[SID4243530]
High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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14
[SID4243530]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]interleukin-2 precursor [Mus musculus] [gi:7110653]
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15
[SID4243530]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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16
[SID4243530]
Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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17
[SID4243530]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1 [AID1009, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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18
[SID4243530]
uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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19
[SID4243530]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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20
[SID4243530]
uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay [AID624204, Type: screening]sentrin-specific protease 1 [Homo sapiens] [gi:7657550]
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