Sodium Chloride (CID 5234) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(13)
 
 
Inconclusive(2)
 
 
Unspecified(29)
 
 
Top Targets:
alpha CA I II..(4)
 
 
Tryp SPc(3)
 
 
BioAssay Types:
Literature(29)
 
 
BioActivity Types:
Ki(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 45   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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2
[SID103770557]
Ki 52Inhibition of Streptococcus pneumoniae beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay [AID552785, Type: Literature]
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3
[SID103770557]
Ki 460Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay [AID647373, Type: Literature]
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4
[SID103770557]
Ki 490Inhibition of Salmonella Typhimurium carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598732, Type: Literature]
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5
[SID103770557]
Ki 770Inhibition of Salmonella Typhimurium carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598731, Type: Literature]
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6
[SID103770557]
Ki 890Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5 [AID587132, Type: Literature]
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7
[SID103770557]
Ki 2700Inhibition of Helicobacter pylori alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay [AID677271, Type: Literature]
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8
[SID103770557]
Ki 6000Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 [AID587130, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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9
[SID103770557]
Ki 6000Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598726, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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10
[SID103770557]
Ki 8300Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay [AID677270, Type: Literature]
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11
[SID103770557]
Ki 200000Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598728, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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12
[SID103770557]
Ki 200000Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 [AID587131, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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13
[SID103770557]
 Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M24 after 20 mins by Western blotting [AID632430, Type: Literature]Suppressor of tumorigenicity 14 protein [gi:13124575]
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14
[SID103770557]
 Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M69 after 20 mins by Western blotting [AID632431, Type: Literature]Suppressor of tumorigenicity 14 protein [gi:13124575]
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15
[SID103770557]
 Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M69 after 20 mins by cell-based ELISA-like assay [AID632432, Type: Literature]Suppressor of tumorigenicity 14 protein [gi:13124575]
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16
[SID103770557]
 Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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17
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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18
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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19
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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20
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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21
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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22
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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23
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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24
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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25
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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26
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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27
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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28
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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29
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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30
[SID103770557]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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31
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6C3F1 mice [AID200, Type: other]
View
32
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model HT29;CX-1 Human Adenocarcinoma (MER+) (intrarenal inoculation) in NU/NU BALB/C (nude) mice [AID208, Type: other]
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33
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Colon Carcinoma 38 (subcutaneous) in B6C3F1 mice [AID214, Type: other]
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34
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Mammary Adenocarcinoma CD8F1 (subcutaneous) in CD8F1 [AID220, Type: other]
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35
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID256, Type: other]
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36
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Lewis Lung Carcinoma (intravenous) in B6C3F1 mice [AID276, Type: other]
View
37
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Amelanotic Melanoma (LOX) (intraperitoneal) in NU/NU BALB/C (nude) mice [AID280, Type: other]
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38
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Sarcoma M5076 (intraperitoneal) in B6C3F1 mice [AID292, Type: other]
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39
[SID48414457]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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40
[SID48414457]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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41
[SID48414457]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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42
[SID48414457]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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43
[SID48414457]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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44
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Mammary Carcinoma MX-1 Xenograft (intrarenal inoculation) in NU/NU BALB/C (nude) mice [AID298, Type: other]
View
45
[SID118214]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Lung LX-1 Xenograft (intrarenal inoculation) in NU/NU BALB/C (nude) mice [AID266, Type: other]
View