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sibutramine (CID 5210) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(360)
 
 
Inconclusive(4)
 
 
Unspecified(428)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
 
7TM GPCR Srsx(27)
 
 
 
p450(9)
 
 
CAP ED(5)
 
 
 
Tryp SPc(5)
 
 
 
BioAssay Types:
Screening(249)
 
 
 
Confirmatory(214)
 
 
 
 
 
Literature(47)
 
 
 
 
BioActivity Types:
IC50(123)
 
 
 
 
Potency(89)
 
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 765    Data Row: 811   Total Pages: 41   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103498411]
IC50 0.632DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: confirmatory]Sodium-dependent dopamine transporter [gi:266667]
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2
[SID103498411]
IC50 0.809DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: confirmatory]
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3
[SID103498411]
IC50 2.085DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103498411]
IC50 2.39DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:27151763]
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5
[SID103498411]
IC50 2.722DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: confirmatory]
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6
[SID103498411]
IC50 5.665DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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7
[SID103498411]
EC50 8Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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8
[SID103498411]
EC50 10Cytotoxicity against BESM cells after 88 hrs by HTS assay [AID547621, Type: Literature]
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9
[SID49732001]
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of bacterial viability [AID488956, Type: screening]
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10
[SID48416537]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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11
[SID49732001]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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12
[SID103498411]
Reduction of cumulative food intake in over-night fasted mouse at 10 mg/kg, ip after 3 hrs relative to control [AID307533, Type: Literature]
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13
[SID103498411]
Reduction in food intake in diet-induced obese Wistar rat chronic feeding model at 6 mg/kg, po once daily after 8 days [AID443391, Type: Literature]
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14
[SID49732001]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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15
[SID49732001]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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16
[SID49732001]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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17
[SID49732001]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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18
[SID49732001]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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19
[SID103498411]
Antiobesity activity in high fat diet-fed C57BL/6 mouse assessed as reduction in body weight at 3 mg/kg, po daily measured up to day 137 relative to control [AID661527, Type: Literature]
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20
[SID103498411]
Antiobesity activity in high-fat diet fed Fischer 344 rat DIO model assessed as inhibition of food intake at 1 mg/kg, po after 6 hrs [AID661690, Type: Literature]
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