Serotonin (CID 5202) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(344)
 
 
Top Targets:
7TM GPCR Srx(54)
 
 
7TM GPCR Srsx(16)
 
 
TAS2R(10)
 
 
alpha CA I II..(10)
 
 
Neur chan LBD(6)
 
 
BioAssay Types:
Literature(313)
 
 
Confirmatory(5)
 
 
Screening(1)
 
 
BioActivity Types:
Ki(123)
 
 
EC50(77)
 
 
IC50(52)
 
 
Potency(3)
 
 
Kd(1)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 338    Data Row: 344   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165719]
IC50 3e-07Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-Spiperone [AID62635, Type: Literature]
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2
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658530, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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3
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418831, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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4
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658530, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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5
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418831, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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6
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658530, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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7
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418831, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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8
[SID103165719]
ED50 0.000126Contractile activity in rabbit mesenteric artery [AID337780, Type: other]
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9
[SID103165719]
Ki 0.00013Displacement of [3H]LSD from human 5HT7 receptor [AID611939, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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10
[SID103165719]
Ki 0.00013Displacement of [3H]LSD from human 5HT7 receptor [AID611939, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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11
[SID103165719]
Ki 0.00013Displacement of [3H]LSD from human 5HT7 receptor [AID611939, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
View
12
[SID103165719]
ED50 0.000156Contractile activity in rabbit celiac artery [AID337779, Type: other]
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13
[SID103165719]
Ki 0.0003In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5571, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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14
[SID103165719]
Ki 0.0003In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5571, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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15
[SID103165719]
EC50 0.0005Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding [AID259335, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
16
[SID103165719]
EC50 0.0005Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418829, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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17
[SID103165719]
EC50 0.0005Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding [AID259335, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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18
[SID103165719]
EC50 0.0005Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding [AID259335, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
19
[SID103165719]
EC50 0.0005Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418829, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
View
20
[SID103165719]
EC50 0.0005Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418829, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
View
21
[SID103165719]
IC50 0.00061Displacement of radiolabeled serotonin from human 5HT7 receptor [AID346459, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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22
[SID103165719]
IC50 0.00061Displacement of radiolabeled serotonin from human 5HT7 receptor [AID346459, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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23
[SID103165719]
IC50 0.00061Displacement of radiolabeled serotonin from human 5HT7 receptor [AID346459, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
View
24
[SID103165719]
Ki 0.00062Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells [AID673212, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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25
[SID103165719]
Ki 0.00062Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells [AID673212, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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26
[SID103165719]
Ki 0.00062Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells [AID673212, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
27
[SID103165719]
EC50 0.0007Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells [AID263582, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
28
[SID103165719]
EC50 0.0007Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells [AID263582, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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29
[SID103165719]
EC50 0.0007Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells [AID263582, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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30
[SID103165719]
EC50 0.00086Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658527, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
View
31
[SID103165719]
EC50 0.00086Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658527, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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32
[SID103165719]
EC50 0.00086Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658527, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
View
33
[SID103165719]
IC50 0.0009In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5487, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
View
34
[SID103165719]
IC50 0.0009In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5487, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
View
35
[SID103165719]
IC50 0.00094Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex [AID258785, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
View
36
[SID103165719]
IC50 0.00094Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex [AID258785, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
View
37
[SID103165719]
EC50 0.001Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation [AID259336, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
38
[SID103165719]
EC50 0.001Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation [AID259336, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
39
[SID103165719]
EC50 0.001Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation [AID259336, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
40
[SID103165719]
Ki 0.0011Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting [AID404702, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112821]
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41
[SID103165719]
Ki 0.0011Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting [AID404702, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112821]
View
42
[SID103165719]
Ki 0.0011Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting [AID404702, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112821]
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43
[SID103165719]
Ki 0.0011Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum [AID4686, Type: Literature]
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44
[SID103165719]
Ki 0.0011Binding affinity against 5-hydroxytryptamine 1B receptor of rat striatum. [AID4693, Type: Literature]
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45
[SID103165719]
ED50 0.0012Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor [AID4583, Type: Literature]
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46
[SID103165719]
IC50 0.0012In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor [AID3590, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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47
[SID103165719]
IC50 0.0012In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor [AID3590, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
48
[SID103165719]
IC50 0.0012In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor [AID3590, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
49
[SID103165719]
Ki 0.00126Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor [AID408275, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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50
[SID103165719]
Ki 0.00126Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor [AID408275, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View