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Serotonin (CID 5202) - Compound BioActivity Data
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BioActivity Outcomes:
Active(367)
 
 
Top Targets:
7TM GPCR Srx(72)
 
 
7TM GPCR Srsx(38)
 
 
alpha CA I II..(12)
 
 
TAS2R(9)
 
 
Neur chan LBD(7)
 
 
BioAssay Types:
Literature(344)
 
 
Confirmatory(5)
 
 
Screening(1)
 
 
BioActivity Types:
Ki(129)
 
 
EC50(85)
 
 
IC50(56)
 
 
Potency(3)
 
 
Kd(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 356    Data Row: 367   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165719]
IC50 3e-07Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-Spiperone [AID62635, Type: Literature]
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2
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418831, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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3
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658530, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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4
[SID103165719]
ED50 0.000126Contractile activity in rabbit mesenteric artery [AID337780, Type: Literature]
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5
[SID103165719]
Ki 0.00013Displacement of [3H]LSD from human 5HT7 receptor [AID611939, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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6
[SID103165719]
ED50 0.000156Contractile activity in rabbit celiac artery [AID337779, Type: Literature]
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7
[SID103165719]
Ki 0.0003In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5571, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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8
[SID103165719]
EC50 0.0005Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding [AID259335, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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9
[SID103165719]
EC50 0.0005Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418829, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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10
[SID103165719]
IC50 0.00061Displacement of radiolabeled serotonin from human 5HT7 receptor [AID346459, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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11
[SID103165719]
Ki 0.00062Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells [AID673212, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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12
[SID103165719]
EC50 0.0007Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells [AID263582, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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13
[SID103165719]
EC50 0.00086Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658527, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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14
[SID103165719]
EC50 0.00087Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay [AID733559, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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15
[SID103165719]
Ki 0.0009Displacement of [3H]8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter [AID729712, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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16
[SID103165719]
IC50 0.0009In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5487, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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17
[SID103165719]
IC50 0.00094Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex [AID258785, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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18
[SID103165719]
EC50 0.001Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation [AID259336, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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19
[SID103165719]
Ki 0.0011Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting [AID404702, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112821]
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20
[SID103165719]
Ki 0.0011Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum [AID4686, Type: Literature]
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21
[SID103165719]
Ki 0.0011Binding affinity against 5-hydroxytryptamine 1B receptor of rat striatum. [AID4693, Type: Literature]
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22
[SID103165719]
ED50 0.0012Compound was evaluated for its agonistic activity on 5-hydroxytryptamine 1D receptor [AID4583, Type: Literature]
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23
[SID103165719]
IC50 0.0012In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor [AID3590, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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24
[SID103165719]
Ki 0.00126Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor [AID408275, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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25
[SID103165719]
EC50 0.0015Binding to human 5HT2B receptor expressed in CHO cells [AID259794, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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26
[SID103165719]
IC50 0.0015Inhibition of human 5HT7 receptor [AID340267, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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27
[SID103165719]
EC50 0.0015Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometricimaging plate reader [AID5383, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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28
[SID103165719]
Ki 0.0016Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus [AID375322, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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29
[SID103165719]
Ki 0.0016Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus [AID441264, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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30
[SID103165719]
EC50 0.00163Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay [AID652619, Type: Literature]
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31
[SID103165719]
EC50 0.0017Binding to human 5HT2C receptor expressed in CHO cells [AID259795, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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32
[SID103165719]
Ki 0.0017In vitro affitnity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement. [AID4896, Type: Literature]
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33
[SID103165719]
EC50 0.0017Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometricimaging plate reader [AID5842, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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34
[SID103165719]
Ki 0.0017Binding affinity was measured on 5-hydroxytryptamine 1A receptor in AK cells transfected with human 5-HT1A gene labeled with [3H]-8-OH-DPAT [AID3829, Type: Literature]
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35
[SID103165719]
Ki 0.0017Binding affinity towards 5-hydroxytryptamine 1A receptor [AID4035, Type: Literature]
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36
[SID103165719]
IC50 0.002In vitro inhibition of [125I]IPAPP (0.25 nM) binding to 5-HT1A receptor from bovine hippocampus [AID3466, Type: Literature]
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37
[SID103165719]
IC50 0.002In vitro inhibition of azido-[125I]-IPAPP (0.25 nM) binding to 5-HT1A receptor from bovine hippocampus [AID3465, Type: Literature]
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38
[SID103165719]
Ki 0.002Binding affinity was determined against 5-hydroxytryptamine 1A receptor was determined in male Sprague-Dawley rat brain. [AID4043, Type: Literature]
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39
[SID103165719]
Ki 0.002Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand. [AID3695, Type: Literature]
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40
[SID103165719]
Ki 0.002In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor [AID4627, Type: Literature]
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41
[SID103165719]
Ki 0.0021The compound was tested for their binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampus using [3H]8-OH-DPAT as radioligand. [AID4365, Type: Literature]
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42
[SID103165719]
Ki 0.00248Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1A receptor in CHO-K1 cells [AID3835, Type: Literature]
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43
[SID103165719]
Ki 0.00248Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand [AID3822, Type: Literature]
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44
[SID103165719]
Ki 0.0025The compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1A receptor [AID3943, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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45
[SID103165719]
Ki 0.0025The compound was tested for their binding affinity towards 5-hydroxytryptamine 1B receptor from rat striatum using [3H]5-HT as radioligand. [AID4709, Type: Literature]
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46
[SID103165719]
IC50 0.00255Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
View
47
[SID103165719]
IC50 0.0026Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor [AID3770, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
View
48
[SID103165719]
Ki 0.0026Displacement of [3H]8OH-DPAT from 5HT1A in rat brain cerebral cortex after 15 mins by scintillation counting [AID620966, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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49
[SID103165719]
EC50 0.0026Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay [AID733560, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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50
[SID103165719]
IC50 0.0027Inhibition of rat 5-HT receptor [AID566271, Type: Literature]
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