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Serotonin (CID 5202) - Compound BioActivity Data
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BioActivity Outcomes:
Active(448)
 
 
Inactive(385)
 
 
Inconclusive(64)
 
 
Unspecified(199)
 
 
Top Targets:
7tm 4(218)
 
 
 
 
 
p450(20)
 
 
 
 
TAS2R(18)
 
 
 
 
alpha CA I II..(14)
 
 
 
Neur chan LBD(14)
 
 
 
 
BioAssay Types:
Literature(651)
 
 
 
 
 
Confirmatory(386)
 
 
 
 
 
Screening(4)
 
 
 
BioActivity Types:
Potency(313)
 
 
 
 
 
Ki(150)
 
 
 
 
EC50(98)
 
 
 
 
IC50(88)
 
 
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 813    Data Row: 1096   Total Pages: 55   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165719]
IC50 3e-07Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-Spiperone [AID62635, Type: Literature]
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2
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418831, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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3
[SID103165719]
EC50 9e-05Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658530, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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4
[SID103165719]
ED50 0.000126Contractile activity in rabbit mesenteric artery [AID337780, Type: Literature]
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5
[SID103165719]
Ki 0.00013Displacement of [3H]LSD from human 5HT7 receptor [AID611939, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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6
[SID103165719]
ED50 0.000156Contractile activity in rabbit celiac artery [AID337779, Type: Literature]
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7
[SID103165719]
IC50 0.00029Binding affinity to human 5-HT7 receptor by radioligand displacement assay [AID751846, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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8
[SID103165719]
Ki 0.0003In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5571, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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9
[SID103165719]
EC50 0.0004Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay [AID752429, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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10
[SID103165719]
IC50 0.00049Binding affinity to human 5-HT7 receptor by radioligand displacement assay [AID752210, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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11
[SID103165719]
EC50 0.0005Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding [AID259335, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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12
[SID103165719]
EC50 0.0005Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay [AID418829, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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13
[SID103165719]
IC50 0.00061Displacement of radiolabeled serotonin from human 5HT7 receptor [AID346459, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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14
[SID103165719]
Ki 0.00062Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells [AID673212, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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15
[SID103165719]
EC50 0.0007Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells [AID263582, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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16
[SID103165719]
EC50 0.00086Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay [AID658527, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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17
[SID103165719]
EC50 0.000871Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay [AID733559, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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18
[SID103165719]
IC50 0.0009In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex [AID5487, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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19
[SID103165719]
Ki 0.0009Displacement of [3H]8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter [AID729712, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
20
[SID103165719]
IC50 0.00094Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex [AID258785, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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