carbamylhydrazine (CID 5196) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(118)
 
 
Inconclusive(15)
 
 
Unspecified(4)
 
 
Top Targets:
p450(10)
 
 
 
 
7TM GPCR Srx(4)
 
 
Pyruvate Kina..(4)
 
 
Pyr redox dim(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(117)
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(96)
 
 
 
IC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 143   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103236089]
IC50 0.0067Compound was evaluated for inhibition of Microbial tyramine oxidase [AID215956, Type: Literature]
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2
[SID103236089]
IC50 6.7Inhibitory concentration for human liver monoamine oxidase A [AID241583, Type: Literature]Amine oxidase [flavin-containing] A [gi:113978]
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3
[SID103236089]
IC50 6.7Inhibitory concentration for human liver monoamine oxidase B [AID241584, Type: Literature]Amine oxidase [flavin-containing] B [gi:113980]
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4
[SID103236089]
 Antinociceptive activity in Swiss mouse assessed inhibition of formaldehyde-induced paw licking at 0.31 mmol/kg, ip administered 30 mins prior to formaldehyde-challenge measured from 15 to 30 mins [AID649113, Type: Literature]
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5
[SID103236089]
 Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 0.31 mmol/kg, ip administered 30 mins prior to carrageenan-challenge measured up to 6 hrs [AID649117, Type: Literature]
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6
[SID103236089]
 Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 0.62 mmol/kg, ip administered 30 mins prior to carrageenan-challenge measured up to 6 hrs [AID649118, Type: Literature]
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7
[SID103236089]
IC50 2192Activity against lymphocytic murine leukemia cell line L1210 using MTS/PES microculture tetrazolium assay [AID96456, Type: Literature]
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8
[SID103236089]
 Calculated partition coefficient (clogP) [AID27913, Type: Literature]
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9
[SID103236089]
 Calculated partition coefficient (clogP) (SlogP) [AID28658, Type: Literature]
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10
[SID11111784]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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11
[SID11111784]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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12
[SID90341010]
Potency 0.4467qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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13
[SID90341010]
Potency 0.4467qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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14
[SID90341010]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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15
[SID90341010]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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16
[SID90341010]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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17
[SID90341010]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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18
[SID90341010]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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19
[SID90341010]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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20
[SID90341010]
Potency Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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21
[SID90341010]
Potency Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493107, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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22
[SID11111784]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors [AID901, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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23
[SID11111784]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors [AID901, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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24
[SID11111784]
Potency qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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25
[SID90341010]
Potency High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen [AID488978, Type: confirmatory]chaperonin GroEL [Methanococcus maripaludis S2] [gi:45359078]
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26
[SID90341010]
Potency qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485368, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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27
[SID11111784]
Potency Counterscreen for Glucocerebrosidase Inhibitors: qHTS Assay for Rice alpha-Glucosidase at pH 5.0 [AID997, Type: confirmatory]putative alpha-glucosidase [Oryza sativa Japonica Group] [gi:52076901]
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28
[SID90341010]
Potency qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Kinase [AID504547, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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29
[SID90341010]
Potency qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Mutase [AID504548, Type: confirmatory]2,3-bisphosphoglycerate-independent phosphoglycerate mutase; 2,3-bisphosphoglycerate-independentphos [gi:157877932]
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30
[SID11111784]
 JNK3 AlphaScreen Assay [AID530, Type: confirmatory]Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase [gi:2499604]
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31
[SID90341010]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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32
[SID90341010]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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33
[SID90341010]
Potency qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]MPHOSPH8 gene product [Homo sapiens] [gi:41055989]
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34
[SID11111784]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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35
[SID11111784]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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36
[SID90341010]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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37
[SID90341010]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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38
[SID90341010]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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39
[SID90341010]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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40
[SID90341010]
Potency qHTS of Nrf2 Activators: LOPAC Validation [AID624149, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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41
[SID90341010]
Potency qHTS of Nrf2 Activators: LOPAC Validation [AID624149, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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42
[SID90341010]
Potency qHTS of Nrf2 Activators: LOPAC Validation [AID624149, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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43
[SID90341010]
Potency qHTS of Nrf2 Activators: LOPAC Validation [AID624149, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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44
[SID11111784]
 IkB Signaling [AID445, Type: confirmatory]nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Homo sapiens] [gi:10092619]
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45
[SID11111784]
 IkB Signaling [AID445, Type: confirmatory]nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Homo sapiens] [gi:10092619]
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46
[SID90341010]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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47
[SID11111784]
 qHTS Assay for Inhibitors of PDE-IV [AID607, Type: confirmatory]phosphodiesterase 4B, cAMP-specific isoform 1 [Homo sapiens] [gi:82799486]
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48
[SID11111784]
 qHTS Assay for Inhibitors of PDE-IV [AID607, Type: confirmatory]phosphodiesterase 4B, cAMP-specific isoform 1 [Homo sapiens] [gi:82799486]
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49
[SID90341010]
Potency qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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50
[SID90341010]
Potency qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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