miglustat (CID 51634) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(46)
 
 
Inactive(24)
 
 
Unspecified(57)
 
 
Top Targets:
DUF608(6)
 
 
 
Glucosylceram..(3)
 
 
 
GH31 MGAM SI..(2)
 
 
Glyco hydro 3..(2)
 
 
GH31(1)
 
 
BioAssay Types:
Literature(111)
 
 
 
 
Screening(2)
 
 
Confirmatory(2)
 
 
BioActivity Types:
IC50(40)
 
 
 
Ki(3)
 
 
 
EC50(2)
 
 
Potency(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 127    Data Row: 127   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103277564]
IC50 0.1Inhibition of lysosomal alpha-glucosidase by HPLC [AID466672, Type: Literature]
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2
[SID103277564]
IC50 0.1Inhibition of human lysosomal alpha glucosidase [AID437995, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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3
[SID103277564]
IC50 0.1Inhibition of human lysosomal alpha glucosidase [AID437995, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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4
[SID103277564]
IC50 0.1Inhibition of human lysosomal alpha glucosidase [AID437995, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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5
[SID103277564]
IC50 0.14Inhibition of conduritol beta-epoxide-sensitive mouse glucosylceramidase [AID386381, Type: Literature]Non-lysosomal glucosylceramidase [gi:143018443]
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6
[SID103277564]
IC50 0.23Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis [AID652573, Type: other]Non-lysosomal glucosylceramidase [gi:143018392]
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7
[SID103277564]
IC50 0.23Inhibition of human GBA2 [AID437994, Type: Literature]Non-lysosomal glucosylceramidase [gi:143018392]
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8
[SID103277564]
IC50 0.23Inhibition of GBA2 by HPLC [AID466671, Type: Literature]
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9
[SID103277564]
IC50 0.23Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay [AID553254, Type: other]
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10
[SID103277564]
IC50 0.5Inhibition of sucrase by HPLC [AID466667, Type: Literature]
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11
[SID103277564]
IC50 0.58Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID208985, Type: Literature]
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12
[SID103277564]
IC50 0.6Inhibition of sucrase in mouse intestinal input by glucose release assay [AID553255, Type: other]Sucrase-isomaltase, intestinal [Cricetulus griseus] [gi:344247361]
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13
[SID103277564]
IC50 1Inhibition of rice alpha glucosidase [AID437996, Type: Literature]
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14
[SID103277564]
IC50 2.1Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase [AID104668, Type: Literature]
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15
[SID103277564]
IC50 2.7Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID91639, Type: Literature]
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16
[SID103277564]
Ki 3.7Competitive Inhibitory activity against Endoplasmic reticulum Alpha-Glucosidase II [AID36810, Type: Literature]
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17
[SID103277564]
IC50 4.6Inhibition of rat liver Alpha-glucosidase II [AID617701, Type: Literature]
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18
[SID103277564]
IC50 5.3Inhibition of lysosomal Alpha-Glucosidase II in rat liver [AID36809, Type: Literature]
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19
[SID103277564]
IC50 9Inhibition of maltase by HPLC [AID466668, Type: Literature]
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20
[SID103277564]
IC50 9Inhibition of maltase in mouse intestinal input by glucose release assay [AID553257, Type: other]Lysosomal alpha-glucosidase [gi:51338793]
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21
[SID103277564]
IC50 10Inhibition of glycogen glycogen de-branching enzyme by HPLC [AID466673, Type: Literature]
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22
[SID103277564]
IC50 13Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID210969, Type: Literature]
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23
[SID103277564]
IC50 15Inhibition of endoplasmic reticulum Alpha-Glucosidase II in rat liver [AID36808, Type: Literature]
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24
[SID103277564]
IC50 20Inhibition of Saccharomyces cerevisiae alpha glucosidase [AID437997, Type: Literature]
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25
[SID103277564]
IC50 20Inhibition of Bacillus stearothermophilus alpha glucosidase [AID437998, Type: Literature]
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26
[SID103277564]
IC50 22Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reaction [AID626355, Type: Literature]
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27
[SID103277564]
IC50 22.9Inhibition mouse glucosylceramide synthase [AID386382, Type: Literature]Ceramide glucosyltransferase [gi:38257364]
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28
[SID103277564]
 Inhibition of endoplasmic reticulum alpha-glucosidase 2 in human HL-60 cells assessed as free oligosaccharide level at 50 uM after 24 hrs [AID579823, Type: Literature]Neutral alpha-glucosidase AB [gi:54037162]
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29
[SID103277564]
 Inhibition of endoplasmic reticulum alpha-glucosidase 1 in human HL-60 cells assessed as free oligosaccharide level at 50 uM after 24 hrs [AID579822, Type: Literature]
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30
[SID103277564]
 Inhibition of rat liver alpha-glucosidase 2 assessed as conversion of Glc2Man7GlcNAc2 to Glc1Man7GlcNAc2 at 100 uM after 1.25 hrs [AID579824, Type: Literature]
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31
[SID103277564]
 Inhibition of rat liver alpha-glucosidase 2 assessed as conversion of Glc2Man7GlcNAc2 to Man7GlcNAc2 at 100 uM after 1.25 hrs [AID579825, Type: Literature]
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32
[SID103277564]
 Increase in long and saturated glucosylceramide level in C57BL/6 mouse testes at 150 mg/kg/day administered with chow [AID386373, Type: Literature]
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33
[SID103277564]
 Increase in very long and polyunsaturated glucosylceramide level in C57BL/6 mouse testes at 150 mg/kg/day administered with chow [AID386374, Type: Literature]
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34
[SID103277564]
 Increase in glucosylceramide level in GBA2 deficient C57BL/6-129S1 mouse testes at 150 mg/kg/day administered with chow [AID386375, Type: Literature]
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35
[SID103277564]
 Increase in glucosylceramide level in GBA2 deficient C57BL/6-129S1 mouse somatic cells at 150 mg/kg/day administered with chow [AID386376, Type: Literature]
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36
[SID103277564]
 Increase in glucosylceramide level in GBA2 deficient C57BL/6-129S1 mouse germ cells at 150 mg/kg/day administered with chow [AID386377, Type: Literature]
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37
[SID103277564]
 Increase in glucosylceramide level in C57BL/6 mouse brain at 1200 mg/kg/day administered with chow [AID386370, Type: Literature]
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38
[SID103277564]
 Increase in glucosylceramide level in C57BL/6 mouse testes administered with chow after 5 days [AID386371, Type: Literature]
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39
[SID103277564]
 Increase in complex glycosylated sphingolipids level in C57BL/6 mouse testes at 15 mg/kg/day administered with chow after 6 to 9 months [AID386363, Type: Literature]
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40
[SID103277564]
 Increase in neutral glycolipids level in C57BL/6 mouse testes [AID386364, Type: Literature]
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41
[SID103277564]
 Effect on glucosylceramide level in C57BL/6 mouse testes at 15 mg/kg/day administered with chow [AID386366, Type: Literature]
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42
[SID103277564]
 Increase in glucosylceramide level in C57BL/6 mouse testes at 300 mg/kg/day administered with chow [AID386367, Type: Literature]
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43
[SID103277564]
 Increase in glucosylceramide level in C57BL/6 mouse spleen administered with chow [AID386368, Type: Literature]
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44
[SID103277564]
 Decrease in testicular very long chain polyunsaturated fatty acid sphingomyelin level in beta-glucosidase 2 deficient C57BL/6-129S1 mouse at 150 mg/kg/day administered with chow [AID386380, Type: Literature]
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45
[SID103277564]
 Drug level in C57BL/6 mouse serum at 15 mg/kg/day assessed as enzyme activity [AID386386, Type: Literature]
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46
[SID103277564]
 Effect on spermatogenesis in C57BL/10 mouse assessed as morphological changes in spermatozoa at 15 mg/kg/day administered with chow [AID386387, Type: Literature]
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47
[SID103277564]
 Effect on spermatogenesis in C57BL/6 mouse assessed as morphological changes in spermatozoa at 150 mg/kg/day administered with chow [AID386388, Type: Literature]
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48
[SID103277564]
 Effect on spermatogenesis in C57BR mouse assessed as morphological changes in spermatozoa at 150 mg/kg/day administered with chow [AID386389, Type: Literature]
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49
[SID103277564]
IC50 50Inhibition of Cellobiase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID52058, Type: Literature]
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50
[SID103277564]
IC50 50Inhibition of golgi Alpha-mannosidase II in rat liver [AID35262, Type: Literature]
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