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1-O-Acetylgeopyxin A (CID 51361444) - Compound BioActivity Data
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BioActivity Outcomes:
Active(32)
 
 
Inactive(172)
 
 
Inconclusive(10)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srsx(8)
 
 
 
ABCC CFTR1(8)
 
 
 
 
7TM GPCR Srx(7)
 
 
PAX(4)
 
 
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(147)
 
 
 
 
Confirmatory(53)
 
 
 
 
 
Literature(15)
 
 
 
BioActivity Types:
Potency(34)
 
 
 
 
IC50(14)
 
 
 
 
AC50(6)
 
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 197    Data Row: 218   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID121286198]
IC50_Mean 0.293Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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2
[SID121286198]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID121286198]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID160704179]
IC50 2.37Cytotoxicity against human SF268 cells after 72 hrs by Alamar blue assay [AID659839, Type: Literature]
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5
[SID160704179]
IC50 3.48Cytotoxicity against human MCF7 cells after 72 hrs by Alamar blue assay [AID659840, Type: Literature]
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6
[SID160704179]
IC50 3.52Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar blue assay [AID659838, Type: Literature]
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7
[SID160704179]
IC50 3.88Cytotoxicity against human PC3M cells after 72 hrs by Alamar blue assay [AID659841, Type: Literature]
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8
[SID121286198]
AC50_uM 4.07HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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9
[SID160704179]
IC50 4.11Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar blue assay [AID659842, Type: Literature]
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10
[SID121286198]
Potency 5.0119qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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11
[SID121286198]
Potency 5.6234qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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12
[SID121286198]
Potency 5.8048qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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13
[SID121286198]
Potency 6.5131qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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14
[SID121286198]
Potency 11.2202qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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15
[SID121286198]
Potency 11.2202qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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16
[SID121286198]
AbsAC35_uM 11.32HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Other_Dose_CherryPick_Activity_Set2 [AID743395, Type: confirmatory]
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17
[SID121286198]
Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_Activity [AID743287, Type: screening]
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18
[SID121286198]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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19
[SID121286198]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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20
[SID121286198]
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 [Homo sapiens] [gi:31077205]
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