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MLS003373233 (CID 51361440) - Compound BioActivity Data
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BioActivity Outcomes:
Active(47)
 
 
Inactive(164)
 
 
Inconclusive(8)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srsx(8)
 
 
 
7TM GPCR Srx(7)
 
 
Alpha TIF(5)
 
 
 
SRC-1(5)
 
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(157)
 
 
 
 
Confirmatory(52)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(34)
 
 
 
 
IC50(10)
 
 
 
 
AC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 201    Data Row: 221   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID121286192]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID121286192]
Potency 0.7943qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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3
[SID121286192]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID121286192]
AC50_uM 1.71HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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5
[SID121286192]
IC50 2.296Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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6
[SID121286192]
IC50 2.296Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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7
[SID121286192]
Potency 2.3109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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8
[SID121286192]
Potency 2.3109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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9
[SID121286192]
AC50_uM 2.58Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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10
[SID121286192]
Potency 3.1623qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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11
[SID121286192]
Potency 5.0119qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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12
[SID121286192]
IC50 5.207Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID602167, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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13
[SID121286192]
AC50_uM 7.06Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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14
[SID121286192]
IC50 8.333Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID602166, Type: confirmatory]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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15
[SID121286192]
Potency 8.9125qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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16
[SID121286192]
AC50_uM 15.78Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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17
[SID121286192]
Potency 35.4813qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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18
[SID121286192]
AC50_uM 38.19PAX8: non-specific cytotoxicity Measured in Cell-Based System Using Plate Reader - 7054-05_Inhibitor_Dose_DryPowder_Activity [AID743021, Type: confirmatory]
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19
[SID121286192]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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20
[SID121286192]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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