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MLS003270055 (CID 51361124) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(166)
 
 
Inconclusive(8)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srsx(8)
 
 
 
ABCC CFTR1(7)
 
 
 
 
7TM GPCR Srx(7)
 
 
RasGEF(4)
 
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(139)
 
 
 
 
Confirmatory(43)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(34)
 
 
 
 
IC50(9)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 174    Data Row: 188   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID121285802]
Potency 0.5805qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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2
[SID121285802]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID121285802]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID121285802]
IC50_CF-PAF_Mean 17.8Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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5
[SID121285802]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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6
[SID121285802]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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7
[SID121285802]
Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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8
[SID121285802]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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9
[SID121285802]
Luminescence-based cell-based primary high throughput confirmation assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652134, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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10
[SID121285802]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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11
[SID121285802]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_5, Type: confirmatory]
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12
[SID121285802]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_6, Type: confirmatory]
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13
[SID121285802]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_2, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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14
[SID121285802]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_3, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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15
[SID121285802]
Potency 5.6234qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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16
[SID121285802]
IC50 67.484Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): Luminescence-based cell-based high throughput dose response assay for nonselective inhibitors/assay artifacts using AP2 mutant SF-1 (NR5A1) Transactivation Assay [AID687018, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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17
[SID121285802]
IC50 67.484Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID687017, Type: confirmatory]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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18
[SID121285802]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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19
[SID121285802]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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20
[SID121285802]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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21
[SID121285802]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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22
[SID121285802]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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23
[SID121285802]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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24
[SID121285802]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]interleukin-2 precursor [Mus musculus] [gi:7110653]
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25
[SID121285802]
uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay [AID624204, Type: screening]sentrin-specific protease 1 [Homo sapiens] [gi:7657550]
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26
[SID121285802]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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27
[SID121285802]
TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 [AID624416, Type: screening]Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1] [gi:9629363]
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28
[SID121285802]
Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound Set [AID602162, Type: screening]ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] [gi:9955963]
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29
[SID121285802]
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624414, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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30
[SID121285802]
qHTS for Inhibitors of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624415, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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31
[SID121285802]
Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity [AID651658, Type: screening]fibroblast growth factor 22 precursor [Homo sapiens] [gi:10190672]
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32
[SID121285802]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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33
[SID121285802]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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34
[SID121285802]
Potency qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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35
[SID121285802]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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36
[SID121285802]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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37
[SID121285802]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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38
[SID121285802]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon) [AID602123, Type: screening]DNA-binding ATP-dependent protease La [Escherichia coli str. K-12 substr. MG1655] [gi:16128424]
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39
[SID121285802]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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40
[SID121285802]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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41
[SID121285802]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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42
[SID121285802]
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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43
[SID121285802]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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44
[SID121285802]
Potency qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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45
[SID121285802]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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46
[SID121285802]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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47
[SID121285802]
MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_SinglePoint_HTS_Activity [AID652197, Type: screening]ERAP1 protein [Homo sapiens] [gi:21315078]
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48
[SID121285802]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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49
[SID121285802]
Potency qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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50
[SID121285802]
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set [AID588501, Type: Literature]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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