MLS001074635 (CID 51358933) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(412)
 
 
Inconclusive(9)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
BRLZ(5)
 
 
Peptidase C48(5)
 
 
Nuc rec co-ac..(4)
 
 
BioAssay Types:
Screening(308)
 
 
 
Confirmatory(108)
 
 
 
 
 
Literature(8)
 
 
BioActivity Types:
Potency(92)
 
 
 
 
 
IC50(13)
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 324    Data Row: 431   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID74373418]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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2
[SID74373418]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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3
[SID121282685]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651572, Type: screening]Arfgap1 gene product [Rattus norvegicus] [gi:21489979]
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4
[SID74373418]
 uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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5
[SID74373418]
 uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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6
[SID74373418]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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7
[SID74373418]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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8
[SID74373418]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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9
[SID74373418]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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10
[SID74373418]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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11
[SID74373418]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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12
[SID74373418]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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13
[SID74373418]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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14
[SID74373418]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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15
[SID74373418]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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16
[SID74373418]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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17
[SID74373418]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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18
[SID74373418]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_8, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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19
[SID74373418]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_8, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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20
[SID74373418]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_10, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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21
[SID74373418]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_10, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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22
[SID74373418]
IC50 22.9Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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23
[SID74373418]
IC50 22.9Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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24
[SID74373418]
IC50 25.489Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor [Homo sapiens] [gi:4501997]
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25
[SID74373418]
IC50 25.489Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor [Homo sapiens] [gi:4501997]
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26
[SID74373418]
IC50 35.4Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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27
[SID74373418]
IC50 35.4Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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28
[SID74373418]
Potency 39.8107qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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29
[SID74373418]
EC50 40HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 2 [AID485352, Type: confirmatory]LacZ protein [Escherichia coli] [gi:18073591]
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30
[SID74373418]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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31
[SID74373418]
 Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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32
[SID121282685]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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33
[SID74373418]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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34
[SID121282685]
 PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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35
[SID74373418]
 PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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36
[SID74373418]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
View
37
[SID74373418]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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38
[SID121282685]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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39
[SID74373418]
 uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
View
40
[SID74373418]
 uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
View
41
[SID74373418]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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42
[SID121282685]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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43
[SID74373418]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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44
[SID121282685]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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45
[SID74373418]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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46
[SID74373418]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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47
[SID74373418]
 C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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48
[SID121282685]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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49
[SID121282685]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
View
50
[SID74373418]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
View