SureCN13279924 (CID 51346826) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(1)
 
 
Unspecified(16)
 
 
BioAssay Types:
Literature(24)
 
 
 
 
BioActivity Types:
IC50(14)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 24    Data Row: 24   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124967266]
IC50 0.06Inhibition of recombinant AKR1C3 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay [AID666394, Type: Literature]
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2
[SID124967266]
IC50 0.062Inhibition of AKR1C3 by fluorimetric method [AID577840, Type: Literature]
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3
[SID124967266]
IC50 15Inhibition of AKR1C2 by fluorimetric method [AID577841, Type: Literature]
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4
[SID124967266]
IC50 15.4Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay [AID666395, Type: Literature]
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5
[SID124967266]
IC50 22.7Inhibition of recombinant AKR1C1 assessed as enzyme catalyzed oxidation of S-tetralol by fluorimetric assay [AID658485, Type: Literature]
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6
[SID124967266]
IC50 22.7Inhibition of recombinant AKR1C1 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay [AID666397, Type: Literature]
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7
[SID124967266]
 Inhibition of AKR1C3 expressed in androgen dependent LNCaP cells assessed inhibition of testosterone formation from delta4-androstene-3,17-dione at 10 uM after 48 hrs [AID666409, Type: Literature]
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8
[SID124967266]
IC50 50Inhibition of recombinant AKR1B1 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assay [AID666399, Type: Literature]
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9
[SID124967266]
IC50 50Inhibition of recombinant AKR1B10 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assay [AID666401, Type: Literature]
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10
[SID124967266]
IC50 62.7Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay [AID666398, Type: Literature]
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11
[SID124967266]
IC50 62.7Inhibition of recombinant AKR1C4 assessed as enzyme catalyzed oxidation of S-tetralol by fluorimetric assay [AID658487, Type: Literature]
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12
[SID124967266]
IC50 100Inhibition of recombinant COX1 [AID658480, Type: Literature]
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13
[SID124967266]
IC50 100Inhibition of recombinant COX2 [AID658481, Type: Literature]
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14
[SID124967266]
IC50 100Inhibition of ram seminal vesicle COX1 assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincubated for 5 mins [AID666405, Type: Literature]
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15
[SID124967266]
IC50 100Inhibition of COX2 expressed in baculovirus infected SF-21 cells assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincubated for 5 mins [AID666407, Type: Literature]
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16
[SID124967266]
 Inhibition of COX2 expressed in baculovirus infected SF-21 cells assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate at 100 uM preincubated for 5 mins [AID666408, Type: Literature]
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17
[SID124967266]
 Inhibition of ram seminal vesicle COX1 assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate at 100 uM preincubated for 5 mins [AID666406, Type: Literature]
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18
[SID124967266]
 Selectivity ratio of IC50 for AKR1C2 over IC50 for AKR1C3 [AID577842, Type: Literature]
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19
[SID124967266]
 Selectivity ratio of IC50 for recombinant AKR1C2 to IC50 for recombinant AKR1C3 [AID666396, Type: Literature]
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20
[SID124967266]
 Inhibition of recombinant AKR1B1 assessed as NADP+ dependent reduction of DL-glyceraldehyde at 50 uM by fluorescence assay [AID666400, Type: Literature]
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21
[SID124967266]
 Inhibition of recombinant AKR1B10 assessed as NADP+ dependent reduction of DL-glyceraldehyde at 50 uM by fluorescence assay [AID666402, Type: Literature]
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22
[SID124967266]
 Selectivity ratio of IC50 for recombinant AKR1C1 to IC50 for recombinant AKR1C3 [AID666403, Type: Literature]
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23
[SID124967266]
 Selectivity ratio of IC50 for recombinant AKR1C4 to IC50 for recombinant AKR1C3 [AID666404, Type: Literature]
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24
[SID124967266]
 Antagonist activity at androgen receptor expressed in HeLa-AR3A-PSA-(ARE)4-Luc13 cells assessed as rightward shift of DHT-induced response at 10 uM incubated for 20 hrs at 37 degC by luciferase reporter gene assay [AID658482, Type: Literature]
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