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AC1LAC1Q (CID 511027) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(2)
 
 
Unspecified(7)
 
 
Top Targets:
DEADc(1)
 
 
BioAssay Types:
Literature(19)
 
 
 
 
BioActivity Types:
IC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 19    Data Row: 19   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103642505]
IC50 16Antiviral activity against HCV genotype 1b infected in human BM4-5 cells reduction in RNA level after 5 days by luciferase reporter gene assay relative to control [AID1069919, Type: Literature]
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2
[SID103642505]
Inhibition of ATP dependent RNA unwinding activity of human RNA helicase DDX3 [AID362394, Type: Literature]ATP-dependent RNA helicase DDX3X [gi:3023628]
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3
[SID103642505]
Inhibition of HIV1 replication in human MT4 cells assessed as reduction in reverse transcriptase production at 10 uM [AID362393, Type: Literature]
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4
[SID103642505]
Inhibition of HIV1 replication in human MT4 cells assessed as reduction in reverse transcriptase at 25 uM after 8 days by Western blotting [AID362395, Type: Literature]
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5
[SID103642505]
Inhibition of HIV1 replication in human MT4 cells assessed as p24 capsid protein level at 25 uM after 8 days by ELISA [AID362396, Type: Literature]
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6
[SID103642505]
Antiviral activity against HIV1 transfected in human HeLa cells assessed as reduction of p55 viral protein synthesis at 25 uM [AID362397, Type: Literature]
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7
[SID103642505]
Antiviral activity against HIV1 transfected in human HeLa cells assessed as reduction of p24 viral protein synthesis at 25 uM [AID362398, Type: Literature]
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8
[SID103642505]
Inhibition of macrophage tropic HIV1 AD8 replication in monocyte-derived macrophages assessed as reduction in reverse transcriptase at 25 uM after 5 days by Western blotting [AID362399, Type: Literature]
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9
[SID103642505]
Inhibition of helicase activity of HCV NTPase/helicase using radio-labelled double-stranded RNA as substrate after 30 mins [AID1069925, Type: Literature]
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10
[SID103642505]
Inhibition of macrophage tropic HIV1 AD8 replication in monocyte-derived macrophages p24 capsid protein level at 25 uM after 5 days by ELISA [AID362400, Type: Literature]
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11
[SID103642505]
Toxicity in BALB/c mouse assessed as tissue necrosis at 0.2 to 200 uM, ip administered weekly twice for 5 weeks relative to control [AID362401, Type: Literature]
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12
[SID103642505]
Cytotoxicity against human MT4 cells at 1 to 100 uM after 6 days by colorimetric assay relative to control [AID362402, Type: Literature]
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13
[SID103642505]
Cytotoxicity against human BM4-5 cells after 5 days by Neutral Red dye assay [AID1069918, Type: Literature]
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14
[SID103642505]
Inhibition of helicase activity of HCV NTPase/helicase using radio-labelled double-stranded DNA as substrate after 30 mins [AID1069926, Type: Literature]
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15
[SID103642505]
Cytotoxicity against human HuH7 cells assessed as beta-actin levels relative to control [AID1069922, Type: Literature]
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16
[SID103642505]
Selectivity index, ratio of beta-actin level in human HuH7 cells to viral RNA level in HCV infected in human Huh7 cells [AID1069923, Type: Literature]
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17
[SID103642505]
Antiviral activity against HCV infected in human Huh7 cells assessed as reduction in RNA level by luciferase reporter gene assay relative to control [AID1069924, Type: Literature]
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18
[SID103642505]
Inhibition of NTPase activity of HCV NTPase/helicase using 105 microM gamma-[32P]ATP as substrate up to 0.7 mM after 30 mins [AID1069921, Type: Literature]
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19
[SID103642505]
Inhibition of NTPase activity of HCV NTPase/helicase using 1 x 10'-5 M gamma-[32P]ATP as substrate up to 0.7 mM after 30 mins [AID1069920, Type: Literature]
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